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Author (up) Blagonravov, M.L.; Bryk, A.A.; Medvedeva, E.V.; Goryachev, V.A.; Chibisov, S.M.; Kurlaeva, A.O.; Agafonov, E.D.
Title Structure of Rhythms of Blood Pressure, Heart Rate, Excretion of Electrolytes, and Secretion of Melatonin in Normotensive and Spontaneously Hypertensive Rats Maintained under Conditions of Prolonged Daylight Duration Type Journal Article
Year 2019 Publication Bulletin of Experimental Biology and Medicine Abbreviated Journal Bull Exp Biol Med
Volume 168 Issue 1 Pages 18-23
Keywords Animals; arterial hypertension; biological rhythms; excessive exposure to light; melatonin
Abstract We studied the structure of rhythms of BP, HR (by telemetric monitoring), electrolyte excretion (by capillary electrophoresis), and products of epiphyseal melatonin (by the urinary concentration of 6-sulfatoxymelatonin measured by ELISA) in normotensive Wistar-Kyoto rats and spontaneously hypertensive SHR rats maintained at 16/8 h and 20/4 h light-dark regimes. In Wister-Kyoto rats exposed to prolonged daylight, we observed changes in the amplitude, rhythm power (% of rhythm), and range of oscillations of systolic BP; HR mezor decreased. In SHR rats, mezor of HR also decreased, but other parameters of rhythms remained unchanged. Changes in electrolyte excretion were opposite in normo- and hypertensive rats. Under conditions of 20/4 h light-dark regime, daytime melatonin production tended to increase in normotensive rats and significantly increased in SHR rats. At the same time, nighttime melatonin production did not change in both normotensive and hypertensive animals. As the secretion of melatonin has similar features in animals of both lines, we can say that the epiphyseal component of the “biological clock” is not the only component of the functional system that determines the response of the studied rhythms to an increase in the duration of light exposure.
Address V. A. Frolov Department of General Pathology and Pathophysiology, Institute for Medicine, Peoples' Friendship University of Russia, Moscow, Russia
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0007-4888 ISBN Medium
Area Expedition Conference
Notes PMID:31741240 Approved no
Call Number GFZ @ kyba @ Serial 2755
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