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Author Skene, D.J.; Arendt, J. url  doi
openurl 
  Title Circadian rhythm sleep disorders in the blind and their treatment with melatonin Type Journal Article
  Year 2007 Publication Sleep Medicine Abbreviated Journal Sleep Med  
  Volume 8 Issue 6 Pages 651-655  
  Keywords Human Health; Blindness/*complications; Chronotherapy; Circadian Rhythm/drug effects; Humans; Melatonin/*administration & dosage; Sleep/drug effects; Sleep Disorders, Circadian Rhythm/*drug therapy/*etiology; Treatment Outcome  
  Abstract People who are blind, in addition to having to cope with partial or no sight, have an added handicap; the transmission of ocular light from the retina to their circadian clock is impaired. At its worse, for example in people with both eyes enucleated, this lesion results in desynchronisation of the biological clock (located in the hypothalamic suprachiasmatic nuclei) from the 24h day/night environment. While in a desynchronised state, symptoms akin to jet lag are experienced (e.g., daytime sleepiness, poor night sleep, reduced alertness and performance during waking). This is a lifelong condition. Daily administration of exogenous melatonin is the current treatment of choice for this so-called “non-24h sleep/wake disorder”. Melatonin has been shown to correct the underlying circadian rhythm abnormality as well as improve sleep and reduce daytime napping. The effectiveness of melatonin therapy depends upon its time of administration relative to the timing of the person's circadian clock. If practicable, assessment of an individual's circadian phase (by measurement of the endogenous melatonin rhythm in plasma, saliva or urine) is recommended prior to commencing treatment to optimise melatonin's effectiveness.  
  Address Centre for Chronobiology, School of Biomedical and Molecular Sciences, University of Surrey, Guildford GU2 7XH, UK. d.skene@surrey.ac.uk  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1389-9457 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:17420154 Approved no  
  Call Number (up) LoNNe @ kagoburian @ Serial 811  
Permanent link to this record
 

 
Author Crowley, S.J.; Suh, C.; Molina, T.A.; Fogg, L.F.; Sharkey, K.M.; Carskadon, M.A. url  doi
openurl 
  Title Estimating the dim light melatonin onset of adolescents within a 6-h sampling window: the impact of sampling rate and threshold method Type Journal Article
  Year 2015 Publication Sleep Medicine Abbreviated Journal Sleep Medicine  
  Volume 20 Issue Pages 59-66  
  Keywords Human Health  
  Abstract  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1389-9457 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number (up) LoNNe @ kyba @ Serial 1324  
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Author Peixoto, C.A.T.; da Silva, A.G.T.; Carskadon, M.A.; Louzada, F.M. url  doi
openurl 
  Title Adolescents living in homes without electric lighting have earlier sleep times Type Journal Article
  Year 2009 Publication Behavioral Sleep Medicine Abbreviated Journal Behav Sleep Med  
  Volume 7 Issue 2 Pages 73-80  
  Keywords Human Health; Sleep  
  Abstract The aim of this project was to compare circadian rhythmicity of a group of 37 adolescents (14 girls), aged 11 to 16 (mean age = 13.1 +/- 1.7 years), with and without electricity at home. Twenty students attended morning school (07:30-11:30), and 17 attended evening school classes (19:00-22:30). Eleven adolescents had no electric lighting at home (5 attended morning classes and 6 attended evening classes). They completed a sleep log and wore a wrist actigraph for 5 consecutive days. Saliva samples were collected to assess DLMO. Data were compared by ANOVA and showed later timing and a more extended sleep period for those who attended late classes. Those adolescents without electricity at home had significantly earlier sleep onset on school days. As to DLMO, a trend to a delay was observed in the groups who had electric lighting.  
  Address Department of Physiology, Universidade Federal do Parana, Brazil. pedatardelli@yahoo.com.br  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1540-2002 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:19330580 Approved no  
  Call Number (up) LoNNe @ kyba @ Serial 1481  
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Author Joo, E.Y.; Abbott, S.M.; Reid, K.J.; Wu, D.; Kang, J.; Wilson, J.; Zee, P.C. url  doi
openurl 
  Title Timing of light exposure and activity in adults with delayed sleep-wake phase disorder Type Journal Article
  Year 2016 Publication Sleep Medicine Abbreviated Journal Sleep Med  
  Volume 32 Issue Pages 259-265  
  Keywords Human Health  
  Abstract OBJECTIVE: To characterize the patterns of light exposure and physical activity level and assess their relationship with sleep quality and depressive symptoms in adults with delayed sleep-wake phase disorder (DSWPD). METHODS: 42 DSWPD (22 female, mean age 34.5 y) and 26 (+/-4 years) age-and-sex-matched controls (12 female, mean age 33.4 y) underwent seven days of light and activity monitoring. RESULTS: Individuals with DSWPD had significantly delayed bed times and wake times, but similar sleep duration compared to controls. Subjective sleep quality (Pittsburgh Sleep Quality Index (PSQI)) was poorer in DSWPDs compared to controls. Those with DSWPD had significantly more activity and light exposure late at night (2:00-4:00) and significantly less activity and light exposure in the morning (8:00-11:00). Total 24 h levels of light and activity were not significantly different between DSWPD and controls. However, the DSWPD group had significantly more light exposure than controls 22 h after waking, during their sleep period. Later light exposure correlated with higher depression scores [Beck Depression Index (BDI)] and poorer sleep quality (PSQI). CONCLUSIONS: The light exposure patterns observed in DSWPD likely contribute to and perpetuate the chronically delayed sleep and wake phase in these patients. In addition, increased light exposure during the sleep period may also contribute to the poor sleep quality and mood disorders that are common in these individuals.  
  Address Department of Neurology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA. Electronic address: p-zee@northwestern.edu  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1389-9457 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:27964860 Approved no  
  Call Number (up) LoNNe @ kyba @ Serial 1639  
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