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Author (up) Bukalev, A.V.; Vinogradova, I.A.; Zabezhinskii, M.A.; Semenchenko, A.V.; Anisimov, V.N. url  doi
openurl 
  Title Light pollution increases morbidity and mortality rate from different causes in female rats Type Journal Article
  Year 2013 Publication Advances in Gerontology Abbreviated Journal Adv Gerontol  
  Volume 3 Issue 3 Pages 180-188  
  Keywords light-at-night; spontaneous tumors; nontumor pathology epiphysis; rats; animals; mammals  
  Abstract The influence of different light regimes (constant light, LL; constant darkness, DD; standard light regime, LD, 12 hours light/12 hours darkness; and natural lighting of the northwest of Russia (NL) on non-tumor pathology revealed in the post-mortem examination of female rats has been studied. It was found that keeping 25-days-old animals under LL and NL conditions led to an increase in the number of infectious diseases and the substantially faster development of spontaneous tumors (2.9 and 3.3 diseases per one rat, respectively), variety of nontumor pathology found in dead rats, compared with the animals in standard (standard light) regime (1.72 diseases per one rat). Light deprivation (DD) led to a substantial reduction in the development of new growth, as well as nontumor and infectious diseases (1.06 diseases per one rat), compared to the same parameters in a standard light regime.  
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  ISSN 2079-0570 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number IDA @ john @ Serial 89  
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Author (up) Vinogradova, I.A.; Anisimov, V.N.; Bukalev, A.V.; Ilyukha, V.A.; Khizhkin, E.A.; Lotosh, T.A.; Semenchenko, A.V.; Zabezhinski, M.A. url  openurl
  Title Circadian disruption induced by light-at-night accelerates aging and promotes tumorigenesis in young but not in old rats Type Journal Article
  Year 2010 Publication AGING Abbreviated Journal  
  Volume 2 Issue 2 Pages 82-92  
  Keywords Animals; Light-at-night; life span; tumorigenesis; rats  
  Abstract We evaluated the effect of exposure to constant light started at the age of 1 month and at the age of 14 months on the survival, life span, tumorigenesis and age-related dynamics of antioxidant enzymes activity in various organs in comparison to the rats maintained at the standard (12:12 light/dark) light/dark regimen. We found that exposure to constant light started at the age of 1 month accelerated spontaneous tumorigenesis and shortened life span both in male and female rats as compared to the standard regimen. At the same time, the exposure to constant light started at the age of 14 months failed to influence survival of male and female rats. While delaying tumors in males, constant light accelerated tumors in females. We conclude that circadian disruption induced by light-at-night started at the age of 1 month accelerates aging and promotes tumorigenesis in rats, however failed affect survival when started at the age of 14 months.  
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  Notes Approved no  
  Call Number LoNNe @ christopher.kyba @ Serial 401  
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Author (up) Vinogradova, I.A.; Anisimov, V.N.; Bukalev, A.V.; Semenchenko, A.V.; Zabezhinski, M.A. url  openurl
  Title Circadian disruption induced by light-at-night accelerates aging and promotes tumorigenesis in rats Type Journal Article
  Year 2009 Publication AGING Abbreviated Journal  
  Volume 10 Issue 1 Pages 855-865  
  Keywords Animals; light-at-night; life span; tumorigenesis; rats  
  Abstract We evaluated the effect of various light/dark regimens on the survival, life span and tumorigenesis in rats. Two hundred eight male and 203 females LIO rats were subdivided into 4 groups and kept at various light/dark regimens: standard 12:12 light/dark (LD); natural lighting of the North-West of Russia (NL); constant light (LL), and constant darkness (DD) since the age of 25 days until natural death. We found that exposure to NL and LL regimens accelerated development of metabolic syndrome and spontaneous tumorigenesis, shortened life span both in male and females rats as compared to the standard LD regimen. We conclude that circadian disruption induced by light-at-night accelerates aging and promotes tumorigenesis in rats. This observation supports the conclusion of the International Agency Research on Cancer that shift-work that involves circadian disruption is probably carcinogenic to humans.  
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  Notes Approved no  
  Call Number LoNNe @ christopher.kyba @ Serial 403  
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Author (up) Vinogradova, I.A.; Ilyukha, V.A.; Khizhkin, E.A.; Uzenbaeva, L.B.; Ilyina, T.N.; Bukalev, A.V.; Goranskii, A.I.; Matveeva, Y.P.; Yunash, V.D.; Lotosh, T.A. url  doi
openurl 
  Title Light pollution, desynchronosis, and aging: State of the problem and solutions Type Journal Article
  Year 2014 Publication Advances in Gerontology Abbreviated Journal Adv Gerontol  
  Volume 4 Issue 4 Pages 260-263  
  Keywords animals  
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  Series Volume Series Issue Edition  
  ISSN 2079-0570 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number LoNNe @ christopher.kyba @ Serial 1067  
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