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Agbaria, S.; Haim, A.; Fares, F.; Zubidat, A.E. |
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Title |
Epigenetic modification in 4T1 mouse breast cancer model by artificial light at night and melatonin – the role of DNA-methyltransferase |
Type |
Journal Article |
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Year |
2019 |
Publication |
Chronobiology International |
Abbreviated Journal |
Chronobiol Int |
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Volume |
36 |
Issue |
5 |
Pages |
629-643 |
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Keywords |
Animals |
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Abstract |
Currently, one of the most disputed hypotheses regarding breast cancer (BC) development is exposure to short wavelength artificial light at night (ALAN) as multiple studies suggest a possible link between them. This link is suggested to be mediated by nocturnal melatonin suppression that plays an integral role in circadian regulations including cell division. The objective of the research was to evaluate effects of 1 x 30 min/midnight ALAN (134 micro Wcm(-2), 460 nm) with or without nocturnal melatonin supplement on tumor development and epigenetic responses in 4T1 tumor-bearing BALB/c mice. Mice were monitored for body mass (Wb) and tumor volume for 3 weeks and thereafter urine samples were collected at regular intervals for determining daily rhythms of 6-sulfatoxymelatonin (6-SMT). Finally, mice were sacrificed and the tumor, lungs, liver, and spleen were excised for analyzing the total activity of DNA methyltransferases (DNMT) and global DNA methylation (GDM) levels. Mice exposed to ALAN significantly reduced 6-SMT levels and increased Wb, tumor volume, and lung metastasis compared with controls. These effects were diminished by melatonin. The DNMT activity and GDM levels showed tissue-specific response. The enzymatic activity and GDM levels were lower in tumor and liver and higher in spleen and lungs under ALAN compared with controls. Our results suggest that ALAN disrupts the melatonin rhythm and potentially leading to increased BC burden by affecting DNMT activity and GDM levels. These data may also be applicable to early detection and management of BC by monitoring melatonin and GDM levels as early biomarker of ALAN circadian disruption. |
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b The Israeli Center for Interdisciplinary Research in Chronobiology , University of Haifa, Haifa , Israel; Zubidat3(at)013.net.il |
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Taylor & Francis |
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English |
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English |
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0742-0528 |
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PMID:30746962 |
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IDA @ john @ |
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2211 |
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Almaida-Pagan, P.F.; Ortega-Sabater, C.; Lucas-Sanchez, A.; Martinez-Nicolas, A.; Espinosa, C.; Esteban, M.A.; Madrid, J.A.; Rol, M.; Mendiola, P.; de Costa, J. |
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Title |
Impact of a shift work-like lighting schedule on the functioning of the circadian system in the short-lived fish Nothobranchius furzeri |
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Journal Article |
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Year |
2018 |
Publication |
Experimental Gerontology |
Abbreviated Journal |
Exp Gerontol |
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Volume |
in press |
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Pages |
in press |
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Keywords |
Animals |
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Abstract |
Adult Nothobranchius furzeri of the MZM-04/10 strain were individually kept and subjected to a “5+2” shifting lighting schedule (SHIFT) for 8weeks in order to evaluate the desynchronizing effects of a simulated human-like shift-work schedule on the functioning of the circadian system (CS). With this aim, sixteen 21-week-old N. furzeri were placed into a Morning, Night and Evening schedule (lights on from 08:00 to 16:00, 00:00 to 08:00 and 16:00 to 00:00h, respectively) and fed once a day in the middle of the corresponding photophase (12:00, 04:00 and 20:00h, respectively). Then, in the weekends (2days), fish were always returned to the Morning shift. As controls, 16 fish were maintained under a non-shifting LD cycle condition (CONTROL) throughout the whole experiment, with lights on from 08:00 to 16:00h. Rest-activity rhythm (RAR) of fish subjected to SHIFT showed several symptoms of chronodisruption, such as a decrease in the percentage of diurnal activity and a reduction of the relative amplitude and the circadian function index with time. When a periodogram analysis was performed, RAR of N. furzeri under SHIFT conditions showed up to three separate circadian components: one longer than 24h (26.5h) that followed the weekly 8h delays; a short-period component (~23h) that was related to the weekend's phase advances, and finally, a 24h component. The shifting LD schedule also affected fish CS at a molecular level, with several significant differences in the expression of core genes of the molecular clock (bmal1, clock, roralpha, rev-erbalpha) between SHIFT and CONTROL animals. RAR impairment along with changes in clock gene expression could be associated with high stress and accelerated aging in these fish. |
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Chronobiology Lab, Department of Physiology, College of Biology, University of Murcia, Mare Nostrum Campus, IUIE, IMIB-Arrixaca, Spain; Ciber Fragilidad y Envejecimiento Saludable (CIBERFES), Madrid, Spain |
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0531-5565 |
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PMID:30184464 |
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Call Number |
GFZ @ kyba @ |
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1999 |
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Almeida, D.N.; Fumega, J.M.-G. |
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Title |
How can planning for sustainability improve Costa de Caparica's nightlife? |
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Journal Article |
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Year |
2012 |
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International Journal of Urban Sustainable Development |
Abbreviated Journal |
International Journal of Urban Sustainable Development |
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4 |
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1 |
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111-123 |
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Keywords |
Economics |
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In the twentieth century, several transformations occurred in the way society used and perceived urban lighting. This allowed the growth of leisure and other activities related to free time and culture into the night period. Night gained an increasing importance among urban policies and therefore required to be framed within these complex urban contexts as well as other planning processes. This article addresses the Polis Program and its contribution to the improvement of Costa de Caparica's nightlife. It aims to analyse the urban renewal intervention of the Polis Program at Costa de Caparica in terms of night economy and sustainability concerns, in light of Egan's sustainable communities' components. The argument is that the planning of night can contribute to the construction of a sustainable community. The main conclusions focus on the importance that should have been given to governance, public participation and equity components of Egan's wheel along the implementation of the programme, as well as in planning processes broadly, towards achieving a sustainable nightlife. |
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1946-3138 |
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LoNNe @ christopher.kyba @ |
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434 |
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Author |
Alves, T.; Almeida, D. |
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Title |
Planning the night – light as a central issue |
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Journal Article |
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2009 |
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In The Regional Studies Association. Regional Studies Association Annual Conference 2009: Understanding and Shaping Regions: Spatial, Social and Economic Futures. Seaford: The Regional Studies Association |
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18 |
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Society |
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LoNNe @ kagoburian @ |
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986 |
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Author |
Asher, A.; Shabtay, A.; Brosh, A.; Eitam, H.; Agmon, R.; Cohen-Zinder, M.; Zubidat, A.E.; Haim, A. |
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“Chrono-functional milk”: The difference between melatonin concentrations in night-milk versus day-milk under different night illumination conditions |
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Journal Article |
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Year |
2015 |
Publication |
Chronobiology International |
Abbreviated Journal |
Chronobiol Int |
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Volume |
32 |
Issue |
10 |
Pages |
1409-1416 |
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Keywords |
Animals; Heart rate; illumination; melatonin; night-milk; chronobiology |
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Pineal melatonin (MLT) is produced at highest levels during the night, under dark conditions. We evaluated differences in MLT-concentration by comparing daytime versus night time milk samples, from two dairy farms with different night illumination conditions: (1) natural dark (Dark-Night); (2) short wavelength Artificial Light at Night (ALAN, Night-Illuminated). Samples were collected from 14 Israeli Holstein cows from each commercial dairy farm at 04:30 h (“Night-milk”) 12:30 h (“Day-milk”) and analyzed for MLT-concentration. In order to study the effects of night illumination conditions on cows circadian rhythms, Heart Rate (HR) daily rhythms were recorded. MLT-concentrations of Night-milk samples from the dark-night group were significantly (p < 0.001) higher than those of Night-illuminated conditions (30.70 +/- 1.79 and 17.81 +/- 0.33 pg/ml, respectively). Interestingly, night illumination conditions also affected melatonin concentrations at daytime where under Dark-Night conditions values are significantly (p < 0.001) higher than Night-Illuminated conditions, (5.36 +/- 0.33 and 3.30 +/- 0.18 pg/ml, respectively). There were no significant differences between the two treatments in the milk yield and milk composition except somatic cell count (SCC), which was significantly lower (p = 0.02) in the Dark-Night group compared with the Night-Illuminated group. Cows in both groups presented a significant (p < 0.01) HR daily rhythm, therefore we assume that in the night illuminated cows feeding and milking time are the “time keeper”, while in the Dark-night cows, HR rhythms were entrained by the light/dark cycle. The higher MLT-concentration in Dark-night cows with the lower SCC values calls upon farmers to avoid exposure of cows to ALAN. Therefore, under Dark-night conditions milk quality will improve by lowering SCC values where separation between night and day of such milk can produce chrono-functional milk, naturally rich with MLT. |
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b Department of Evolutionary and Environmental Biology , Faculty of Natural Sciences, The Israeli Center for Interdisciplinary Research in Chronobiology, University of Haifa , Mount Carmel , Haifa , Israel |
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Publisher |
Taylor & Francis |
Place of Publication |
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English |
Summary Language |
English |
Original Title |
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Abbreviated Series Title |
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ISSN |
0742-0528 |
ISBN |
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Notes |
PMID:26588495 |
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Call Number |
IDA @ john @ |
Serial |
1312 |
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