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Author (up) Hurley, S.; Goldberg, D.; Nelson, D.; Hertz, A.; Horn-Ross, P.L.; Bernstein, L.; Reynolds, P. url  doi
openurl 
  Title Light at night and breast cancer risk among California teachers Type Journal Article
  Year 2014 Publication Epidemiology (Cambridge, Mass.) Abbreviated Journal Epidemiology  
  Volume 25 Issue 5 Pages 697-706  
  Keywords Human Health  
  Abstract BACKGROUND: There is convincing evidence that circadian disruption mediated by exposure to light at night promotes mammary carcinogenesis in rodents. The role that light at night plays in human breast cancer etiology remains unknown. We evaluated the relationship between estimates of indoor and outdoor light at night and the risk of breast cancer among members of the California Teachers Study. METHODS: Indoor light-at-night estimates were based on questionnaire data regarding sleep habits and use of nighttime lighting while sleeping. Estimates of outdoor light at night were derived from imagery data obtained from the US Defense Meteorological Satellite Program assigned to geocoded addresses of study participants. Analyses were conducted among 106,731 California Teachers Study members who lived in California, had no prior history of breast cancer, and provided information on lighting while sleeping. Five thousand ninety-five cases of invasive breast cancer diagnosed 1995-2010 were identified via linkage to the California Cancer Registry. We used age-stratified Cox proportional hazard models to calculate hazard ratios (HRs) with 95% confidence intervals (CIs), adjusting for breast cancer risk factors and neighborhood urbanization and socioeconomic class. RESULTS: An increased risk was found for women living in areas with the highest quintile of outdoor light-at-night exposure estimates (HR = 1.12 [95% CI = 1.00-1.26]; test for trend, P = 0.06). Although more pronounced among premenopausal women (HR = 1.34 [95% CI = 1.07-1.69]; test for trend, P = 0.04), the associations did not differ statistically by menopausal status (test for interaction, P = 0.34). CONCLUSIONS: Women living in areas with high levels of ambient light at night may be at an increased risk of breast cancer. Future studies that integrate quantitative measurements of indoor and outdoor light at night are warranted.  
  Address From the aCancer Prevention Institute of California, Berkeley, CA; bDepartment of Population Sciences, Beckman Research Institute, City of Hope, Duarte, CA; and cDivision of Epidemiology, Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1044-3983 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:25061924; PMCID:PMC4130422 Approved no  
  Call Number LoNNe @ kagoburian @ Serial 762  
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Author (up) Hurley, S.; Nelson, D.O.; Garcia, E.; Gunier, R.; Hertz, A.; Reynolds, P. url  doi
openurl 
  Title A cross-sectional analysis of light at night, neighborhood sociodemographics and urinary 6-sulfatoxymelatonin concentrations: implications for the conduct of health studies Type Journal Article
  Year 2013 Publication International Journal of Health Geographics Abbreviated Journal Int J Health Geogr  
  Volume 12 Issue 1 Pages 39  
  Keywords circadian disruption; 6-sulftoxymelatonin; melatonin; aMT6s, DMSP; light at night  
  Abstract BACKGROUND: There is accumulating evidence that circadian disruption, mediated by alterations in melatonin levels, may play an etiologic role in a wide variety of diseases. The degree to which light-at-night (LAN) and other factors can alter melatonin levels is not well-documented. Our primary objective was to evaluate the degree to which estimates of outdoor environmental LAN predict 6-sulftoxymelatonin (aMT6s), the primary urinary metabolite of melatonin. We also evaluated other potential behavioral, sociodemographic, and anthropomorphic predictors of aMT6s. METHODS: Study participants consisted of 303 members of the California Teachers Study who provided a 24-hour urine specimen and completed a self-administered questionnaire in 2000. Urinary aMT6s was measured using the Buhlmann ELISA. Outdoor LAN levels were estimated from satellite imagery data obtained from the U.S. Defense Meteorological Satellite Program's (DMSP) Operational Linescan System and assigned to study participants' geocoded residential address. Information on other potential predictors of aMT6s was derived from self-administered surveys. Neighborhood socioeconomic status (SES) was based on U.S. Census block group data. RESULTS: Lower aMT6s levels were significantly associated with older age, shorter nights, and residential locations in lower SES neighborhoods. Outdoor sources of LAN estimated using low-dynamic range DMSP data had insufficient variability across urban neighborhoods to evaluate. While high-dynamic range DMSP offered much better variability, it was not significantly associated with urinary aMT6s. CONCLUSIONS: Future health studies should utilize the high-dynamic range DMSP data and should consider other potential sources of circadian disruption associated with living in lower SES neighborhoods.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1476-072X ISBN Medium  
  Area Expedition Conference  
  Notes PMID:24127816; PMCID:PMC3766028 Approved no  
  Call Number IDA @ john @ Serial 142  
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