toggle visibility Search & Display Options

Select All    Deselect All
 |   | 
Details
   print
  Records Links
Author Rahman, S.A.; Bibbo, C.; Olcese, J.; Czeisler, C.A.; Robinson, J.N.; Klerman, E.B. url  doi
openurl 
  Title Relationship between endogenous melatonin concentrations and uterine contractions in late third trimester of human pregnancy Type Journal Article
  Year 2019 Publication Journal of Pineal Research Abbreviated Journal J Pineal Res  
  Volume 66 Issue 4 Pages (down) e12566  
  Keywords Human Health; Melatonin; Pregnancy  
  Abstract In humans, circulating levels of the hormone melatonin and the initiation of spontaneous labor are both higher at night than during the day. Since activation of uterine melatonin receptors can stimulate human in vitro uterine contractions and these receptors are only expressed on the uterine tissue of women in labor, we hypothesized that circulating melatonin concentrations would affect uterine contractions in vivo. We evaluated the impact of light-induced modulation of melatonin secretion on uterine contractions in women during late third-trimester (~36-39 weeks) of pregnancy in two inpatient protocols. We found a significant (p<0.05) positive linear association between circulating melatonin concentrations and the number of uterine contractions under both protocols. On average, uterine contractions increased between 1.4 to 2.1 contractions per 30 minutes for every 10 pg/ml*h increase in melatonin concentration. These findings have both basic science and clinical implications for pregnant women, since endogenous melatonin levels and melatonin receptor activity can be altered by light and/or pharmaceutical agents.  
  Address Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0742-3098 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:30739346 Approved no  
  Call Number GFZ @ kyba @ Serial 2203  
Permanent link to this record
 

 
Author Dominoni, D.M.; de Jong, M.; Bellingham, M.; O'Shaughnessy, P.; van Oers, K.; Robinson, J.; Smith, B.; Visser, M.E.; Helm, B. url  doi
openurl 
  Title Dose-response effects of light at night on the reproductive physiology of great tits (Parus major): Integrating morphological analyses with candidate gene expression Type Journal Article
  Year 2018 Publication Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology Abbreviated Journal J Exp Zool A Ecol Integr Physiol  
  Volume in press Issue Pages (down) in press  
  Keywords Animals  
  Abstract Artificial light at night (ALAN) is increasingly recognized as a potential threat to wildlife and ecosystem health. Among the ecological effects of ALAN, changes in reproductive timing are frequently reported, but the mechanisms underlying this relationship are still poorly understood. Here, we experimentally investigated these mechanisms by assessing dose-dependent photoperiodic responses to ALAN in the great tit (Parus major). We individually exposed photosensitive male birds to one of three nocturnal light levels (0.5, 1.5, and 5 lux), or to a dark control. Subsequent histological and molecular analyses on their testes indicated a dose-dependent reproductive response to ALAN. Specifically, different stages of gonadal growth were activated after exposure to different levels of light at night. mRNA transcript levels of genes linked to the development of germ cells (stra8 and spo11) were increased under 0.5 lux compared to the dark control. The 0.5 and 1.5 lux groups showed slight increases in testis size and transcript levels associated with steroid synthesis (lhr and hsd3b1) and spermatogenesis (fshr, wt1, sox9, and cldn11), although spermatogenesis was not detected in histological analysis. In contrast, all birds under 5 lux had 10 to 30 times larger testes than birds in all other groups, with a parallel strong increase in mRNA transcript levels and clear signs of spermatogenesis. Across treatments, the volume of the testes was generally a good predictor of testicular transcript levels. Overall, our findings indicate that even small changes in nocturnal light intensity can increase, or decrease, effects on the reproductive physiology of wild organisms.  
  Address GELIFES, Groningen Institute for Evolutionary Life Sciences, University of Groningen, Groningen, The Netherlands  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 2471-5638 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:30058288 Approved no  
  Call Number GFZ @ kyba @ Serial 1964  
Permanent link to this record
Select All    Deselect All
 |   | 
Details
   print

Save Citations:
Export Records: