toggle visibility Search & Display Options

Select All    Deselect All
 |   | 
Details
   print
  Records Links
Author (up) Ayaki, M.; Hattori, A.; Maruyama, Y.; Nakano, M.; Yoshimura, M.; Kitazawa, M.; Negishi, K.; Tsubota, K. url  doi
openurl 
  Title Protective effect of blue-light shield eyewear for adults against light pollution from self-luminous devices used at night Type Journal Article
  Year 2016 Publication Chronobiology International Abbreviated Journal Chronobiol Int  
  Volume 33 Issue 1 Pages 134-139  
  Keywords Human health  
  Abstract We investigated sleep quality and melatonin in 12 adults who wore blue-light shield or control eyewear 2 hours before sleep while using a self-luminous portable device, and assessed visual quality for the two eyewear types. Overnight melatonin secretion was significantly higher after using the blue-light shield (P < 0.05) than with the control eyewear. Sleep efficacy and sleep latency were significantly superior for wearers of the blue-light shield (P < 0.05 for both), and this group reported greater sleepiness during portable device use compared to those using the control eyewear. Participants rated the blue-light shield as providing acceptable visual quality.  
  Address a Department of Ophthalmology , Keio University School of Medicine , Shinjuku , Tokyo , Japan  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0742-0528 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:26730983 Approved no  
  Call Number LoNNe @ kyba @ Serial 1330  
Permanent link to this record
 

 
Author (up) Hatori, M.; Gronfier, C.; Van Gelder, R.N.; Bernstein, P.S.; Carreras, J.; Panda, S.; Marks, F.; Sliney, D.; Hunt, C.E.; Hirota, T.; Furukawa, T.; Tsubota, K. url  doi
openurl 
  Title Global rise of potential health hazards caused by blue light-induced circadian disruption in modern aging societies Type Journal Article
  Year 2017 Publication NPJ Aging and Mechanisms of Disease Abbreviated Journal NPJ Aging Mech Dis  
  Volume 3 Issue Pages 9  
  Keywords Commentary; Human Health  
  Abstract Mammals receive light information through the eyes, which perform two major functions: image forming vision to see objects and non-image forming adaptation of physiology and behavior to light. Cone and rod photoreceptors form images and send the information via retinal ganglion cells to the brain for image reconstruction. In contrast, nonimage-forming photoresponses vary widely from adjustment of pupil diameter to adaptation of the circadian clock. nonimage-forming responses are mediated by retinal ganglion cells expressing the photopigment melanopsin. Melanopsin-expressing cells constitute 1-2% of retinal ganglion cells in the adult mammalian retina, are intrinsically photosensitive, and integrate photic information from rods and cones to control nonimage-forming adaptation. Action spectra of ipRGCs and of melanopsin photopigment peak around 480 nm blue light. Understanding melanopsin function lets us recognize considerable physiological effects of blue light, which is increasingly important in our modern society that uses light-emitting diode. Misalignment of circadian rhythmicity is observed in numerous conditions, including aging, and is thought to be involved in the development of age-related disorders, such as depression, diabetes, hypertension, obesity, and cancer. The appropriate regulation of circadian rhythmicity by proper lighting is therefore essential. This perspective introduces the potential risks of excessive blue light for human health through circadian rhythm disruption and sleep deprivation. Knowing the positive and negative aspects, this study claims the importance of being exposed to light at optimal times and intensities during the day, based on the concept of the circadian clock, ultimately to improve quality of life to have a healthy and longer life.  
  Address Department of Ophthalmology, Keio University School of Medicine, Shinjuku-ku, Tokyo Japan.0000 0004 1936 9959grid.26091.3c  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 2056-3973 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:28649427; PMCID:PMC5473809 Approved no  
  Call Number GFZ @ kyba @ Serial 2462  
Permanent link to this record
 

 
Author (up) Nagai, N.; Ayaki, M.; Yanagawa, T.; Hattori, A.; Negishi, K.; Mori, T.; Nakamura, T.J.; Tsubota, K. url  doi
openurl 
  Title Suppression of Blue Light at Night Ameliorates Metabolic Abnormalities by Controlling Circadian Rhythms Type Journal Article
  Year 2019 Publication Investigative Ophthalmology & Visual Science Abbreviated Journal Invest Ophthalmol Vis Sci  
  Volume 60 Issue 12 Pages 3786-3793  
  Keywords Human Health; Animals  
  Abstract Purpose: Light-emitting diodes that emit high-intensity blue light are associated with blue-light hazard. Here, we report that blue light disturbs circadian rhythms by interfering with the clock gene in the suprachiasmatic nucleus (SCN) and that suppression of blue light at night ameliorates metabolic abnormalities by controlling circadian rhythms. Methods: C57BL/6J mice were exposed to 10-lux light for 30 minutes at Zeitgeber time 14 for light pulse with blue light or blue-light cut light to induce phase shift of circadian rhythms. Phase shift, clock gene expression in SCN, and metabolic parameters were analyzed. In the clinical study, healthy participants wore blue-light shield eyewear for 2 to 3 hours before bed. Anthropometric data analyses, laboratory tests, and sleep quality questionnaires were performed before and after the study. Results: In mice, phase shift induced with a blue-light cut light pulse was significantly shorter than that induced with a white light pulse. The phase of Per2 expression in the SCN was also delayed after a white light pulse. Moreover, blood glucose levels 48 hours after the white light pulse were higher than those after the blue-cut light pulse. Irs2 expression in the liver was decreased with white light but significantly recovered with the blue-cut light pulse. In a clinical study, after 1 month of wearing blue-light shield eyeglasses, there were improvements in fasting plasma glucose levels, insulin resistance, and sleep quality. Conclusions: Our results suggest that suppression of blue light at night effectively maintains circadian rhythms and metabolism.  
  Address Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0146-0404 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:31504080 Approved no  
  Call Number GFZ @ kyba @ Serial 2665  
Permanent link to this record
Select All    Deselect All
 |   | 
Details
   print

Save Citations:
Export Records: