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Author Percival, D.
Title Street Furniture in Town and Countryside Type Journal Article
Year 1958 Publication Official Architecture and Planning Abbreviated Journal (up)
Volume 21 Issue 12 Pages 570-573
Keywords Lighting; Design
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Notes Approved no
Call Number GFZ @ kyba @ Serial 2432
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Author Anbalagan, M.; Dauchy, R.; Xiang, S.; Robling, A.; Blask, D.; Rowan, B.; Hill, S.
Title SAT-337 Disruption Of The Circadian Melatonin Signal By Dim Light At Night Promotes Bone-lytic Breast Cancer Metastases Type Journal Article
Year 2019 Publication Journal of the Endocrine Society Abbreviated Journal (up)
Volume 3 Issue Supplement_1 Pages
Keywords Human Health; Cancer; Breast cancer; melatonin; shift work; mouse models
Abstract Breast cancer metastasis to bone is a major source of morbidity and mortality in women with advanced metastatic breast cancer. Morbidity from metastasis to bone is compounded by the fact that they cannot be surgically removed and can only be treated with chemotherapy and/or radiation therapy. Thus, there is critical need to develop new treatment strategies that kill bone metastatic tumors and reduce osteolytic lesions to improve patient quality of life and extend patient survival. Circadian rhythms are daily cycles of ~24 h that control many if not most physiologic processes and their disruption by exposure to light at night (LAN) or jet lag has been shown to be strongly associated with the development of cancer, particularly breast cancer. We have found that disruption of the anti-cancer circadian hormone melatonin (MLT) by light at night can significantly enhance the metastatic potential in breast cancer cells. Our work supports the report of the International Agency for Research on Cancer that shift work is a “probable human carcinogen” and highlights the association between exposure to light at night and invasive breast cancer. We recently reported that human breast tumor xenografts grown in athymic nude female rats housed in a photoperiod of 12h light at day: 12h dim light at night (dLAN, 0.2 lux – blocks the nighttime circadian MLT signal), display resistance to doxorubicin (Dox). More importantly, tumor growth and drug resistance could be blocked by the administration of Dox in circadian alignment with nocturnal MLT during dLAN. Our recent preliminary studies show that poorly invasive ERα positive MCF-7 breast cancer cells, when injected into the tibia (to mimic bone metastatic disease) of Foxn1nu athymic nude mice (which produce a strong circadian nighttime melatonin signal) housed in a dLAN photoperiod (suppressed nocturnal MLT production) developed full blown breast cancer tumors in bone (P<0.05) that are highly osteolytic (P<0.05). Moreover, patients with metastatic breast cancer are routinely treated with doxorubicin, which itself can promote bone damage. Our studies demonstrate that MLT slows the growth of metastatic breast cancer in bone but that the chrono-therapeutic use of doxorubicin in circadian alignment with melatonin in Foxn1nu mice with tibial breast tumors, reduced tumor growth in bone, reduced bone erosion, and promoted the formation of new bone. Successful use of this chronotherapeutic use of Dox and MLT in clinical trials increasing efficacy in preventing or suppressing breast cancer metastasis to bone while decreasing toxic side effects of doxorubicin would provide a revolutionary advancement in the treatment of bone metastatic breast cancer and decrease the morbidity and mortality associated with breast cancer metastasis to bone.
Address Tulane University School of Medicine, New Orleans, LA, United States
Corporate Author Thesis
Publisher Oxford Academic Place of Publication Editor
Language English Summary Language English Original Title
Series Editor Series Title Abbreviated Series Title
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ISSN 2472-1972 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number GFZ @ kyba @ Serial 2433
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Author Żagan, W.,; Skarżyński, K.
Title Analysis of light pollution from floodlighting: Is there a different approach to floodlighting? Type Journal Article
Year 2017 Publication Light and Engineering Abbreviated Journal (up)
Volume 25 Issue 1 Pages 75-82
Keywords LED lighting
Abstract The research which was prepared for this paper was inspired by a real floodlit object. The main distinctive feature is connected with the directionality of its lighting. The „Sezam” building was one of the first to be illuminated in the opposite way to the usual manner of floodlighting. The analysis, based on the measurement of horizontal illuminance on the pavement in front of the building andof theluminance on the facade, leads to some very unusual conclusions. It goes deeper than merely the assessment of the phenomenon of light pollution in the context of floodlighting. Additionally, a short survey about the preferences of lighting directionality in floodlighting and the general concept of light pollution was conducted on a group of over a dozen people. It turned out that people are quite aware of the phenomenon of light pollution and they rather prefer illumination from floodlighting to be from bottom to top.
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Notes Approved no
Call Number GFZ @ kyba @ Serial 2450
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Author Weiss, C.M.
Title The effect of illumination and stage of tide on the attachment of barnacle cyprids Type Journal Article
Year 1947 Publication The Biological Bulletin Abbreviated Journal (up)
Volume 93 Issue 3 Pages 240-249
Keywords animals
Abstract 1. The cyprid larvae of Balanus improvisus were found to settle in a diurnal rhythm with maximum numbers attaching during daylight hours.

2. No consistent pattern of vertical distribution of the cyprids was found.

3. The normal diurnal cycle in rate of attachment of barnacle cyprids was nullified by the use of artificial illumination over the collecting surfaces at night.

4. The magnitude of the cyprid collection on the artificially illuminated surfaces was equal to the collection on the sun-illuminated surfaces in daylight.

5. The intensity of artificial light necessary to produce large cyprid attachments at night was of an order as low as 1 footcandle at the water surface.

6. No correlation was found between the quantity of artificial light at night and the numbers of cyprids attached.

7. The highest rate of cyprid attachment relative to the phase of the tide was found to occur when the waters of upper Biscayne Bay were sampled at the collecting station. This body of water reached the sampling station at low tide and was characterized by a high cyprid population.
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Notes Approved no
Call Number GFZ @ kyba @ Serial 2464
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Author Gunn, D.L.; Walshe, B.M.
Title The Biology and Behaviour of Ptinus Tectus Boie.(Coleoptera, Ptinidae), A Pest of Stored Products: IV. Temperature Preference Type Journal Article
Year 1942 Publication Journal of Experimental Biology Abbreviated Journal (up)
Volume 19 Issue 2 Pages 133-140
Keywords Animals
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Notes Approved no
Call Number GFZ @ kyba @ Serial 2465
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