|   | 
Details
   web
Records
Author (down) Xiang, S.; Dauchy, R.T.; Hoffman, A.E.; Pointer, D.; Frasch, T.; Blask, D.E.; Hill, S.M.
Title Epigenetic inhibition of the tumor suppressor ARHI by light at night-induced circadian melatonin disruption mediates STAT3-driven paclitaxel resistance in breast cancer Type Journal Article
Year 2019 Publication Journal of Pineal Research Abbreviated Journal J Pineal Res
Volume in press Issue Pages e12586
Keywords Animals; Human Health
Abstract Disruption of circadian time structure and suppression of circadian nocturnal melatonin (MLT) production by exposure to dim light at night (dLAN), as occurs with night shift work and/or disturbed sleep-wake cycles, is associated with a significantly increased risk of breast cancer and resistance to tamoxifen and doxorubicin. Melatonin inhibition of human breast cancer chemo-resistance involves mechanisms including suppression of tumor metabolism and inhibition of kinases and transcription factors which are often activated in drug-resistant breast cancer. Signal Transducer and Activator of Transcription 3 (STAT3), frequently overexpressed and activated in Paclitaxel (PTX)-resistant breast cancer, promotes the expression of DNA methyltransferase one (DNMT1) to epigenetically suppresses the transcription of tumor suppressor Aplasia Ras homolog one (ARHI) which can sequester STAT3 in the cytoplasm to block PTX-resistance. We demonstrate that breast tumor xenografts in rats exposed to dLAN and circadian MLT disrupted express elevated levels of phosphorylated and acetylated STAT3, increased DNMT1, but reduced Sirtuin 1 (SIRT1) and ARHI. Furthermore, MLT and/or SIRT1 administration blocked/reversed Interleukin 6 (IL-6)-induced acetylation of STAT3 and its methylation of ARH1 to increase ARH1 mRNA expression in MCF-7 breast cancer cells. Finally, analyses of the I-SPY 1 trial demonstrates that elevated MT1 receptor expression is significantly correlated with pathologic complete response following neo-adjuvant therapy in breast cancer patients. This is the first study to demonstrate circadian disruption of MLT by dLAN driving intrinsic resistance to PTX via epigenetic mechanisms increasing STAT3 expression and that MLT administration can reestablish sensitivity of breast tumors to PTX and drive tumor regression. This article is protected by copyright. All rights reserved.
Address Tulane Circadian Cancer Biology Group, New Orleans, Louisiana
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0742-3098 ISBN Medium
Area Expedition Conference
Notes PMID:31077613 Approved no
Call Number GFZ @ kyba @ Serial 2383
Permanent link to this record
 

 
Author (down) Xia, C.; Yeh, A.G.-O.; Zhang, A.
Title Analyzing spatial relationships between urban land use intensity and urban vitality at street block level: A case study of five Chinese megacities Type Journal Article
Year 2020 Publication Landscape and Urban Planning Abbreviated Journal Landscape and Urban Planning
Volume 193 Issue Pages 103669
Keywords Remote Sensing
Abstract Urban sprawl in urbanizing China has resulted in a series of ecological and environmental problems. Urban planners have been committed to promoting compact development through high-density and mixed land use. However, a problem brought by such compact urban form is the mismatch between physical spaces and socio-economic activities. To date, minimal research has been conducted using spatial statistics to study this issue at the local scales. Moreover, urban night-time vitality has been consistently ignored in existing studies. In the current work, urban land use intensity was analyzed on the basis of street block density and typology, and urban daytime and night-time vitality were measured using small catering business and night-time light data, respectively. The spatial relationships between urban land use intensity and urban vitality were investigated using a local indicator of spatial association (LISA), and five megacities in China were taken as a case study to examine whether variations exist between different cities. Results showed a significant positive spatial autocorrelation between urban land use intensity and urban vitality according to global statistics. Therefore, socio-economic activities are more likely to be abundant in densely developed urban areas. However, local spatial mismatches were found in the five megacities, indicating overcrowded or underutilized urban spaces in all the cities. These relationships were associated with different urban areas (urbanized before 1995 and during 1995–2015), land use conditions (function and mixture) and time periods (day and night). The results of this work will provide a comprehensive understanding of compact city and sustainability.
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0169-2046 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number GFZ @ kyba @ Serial 2697
Permanent link to this record
 

 
Author (down) Wurtman, R.J.
Title The Pineal and Endocrine Function Type Journal Article
Year 1969 Publication Hospital Practice Abbreviated Journal Hospital Practice
Volume 4 Issue 1 Pages 32-37
Keywords Human Health
Abstract Recognition that levels of hormonal secretion vary markedly from day to night has triggered intensive investigation into the influence of environmental light upon endocrine function. These studies have pointed to the pineal gland as a major mediator of a wide variety of hormonal responses involving the gonads, thyroid, and pituitary, and the hypothalamus and other regions of the brain.
Address Human Health
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 2154-8331 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number GFZ @ kyba @ Serial 2037
Permanent link to this record
 

 
Author (down) Wuchterl, G.; Reithofer, M.
Title Licht über Wien V Type Journal Article
Year 2017 Publication Abbreviated Journal
Volume Issue Pages
Keywords Skyglow
Abstract Die hier präsentierte Studie gibt einen detaillierten Überblick zur Entwicklung derLichtverschmutzung über dem Stadtgebiet von Wien in den Jahren 2011 bis 2017 und bietet einePrognose bis 2020. Damit ist international erstmals eine Langzeitstudie über die Entwicklung derLichtverschmutzung einer Großstadt verfügbar. Im Rahmen der begleitenden Untersuchungen sindAussagen über die Verursacher und ihre spezifischen Anteile an der Lichtverschmutzung Wiensmöglich. Die aktuelle Umrüstung auf LED-Technik wird diskutiert und findet Eingang in diePrognose. Neue Messungen und Analysen von internationalen Teams werden kurz vorgestellt undbezüglich ihrer Relevanz vergleichend mit unserer Studie diskutiert.
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language German Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number GFZ @ kyba @ Serial 2717
Permanent link to this record
 

 
Author (down) Wuchterl, G.; Reithofer, M.
Title Licht über Wien VI Type Journal Article
Year 2018 Publication Abbreviated Journal
Volume Issue Pages
Keywords Skyglow
Abstract Im Zentrum Wiens sättigt die Erhellung der Nacht, am Stadtrand sinken die jährlichen Zuwächse, wäh-rend im Abstand von 36 Kilometern (Großmugl) die Nächte um 10 % pro Jahr heller werden.Der Gesamtaufwand der Wiener Lichtglocke liegt 2018 bei 37 MW. Der Verlauf von 2011 bis 2018 zeigt ein deutliches Lichtmaximum um 2014 und 2015. Danach stellen wir einen allmählichen Rückgang fest.Der Verlauf der Lichtglocke und noch deutlicher jener der Einzelstationen zeigt signifikante Schwankun-gen von Jahr zu Jahr. Zur Aufklärung der Ursachen, die weder astronomisch noch meteorologisch sind, wur-den monatliche Analysen des Lichtmessnetzes mit Daten des Luftmessnetzes der Wiener MA 22 kombiniert. Die natürliche Variation über das Jahr wurde genutzt, um Zusammenhänge zwischen den Monatsmedianen von Luftfeuchtigkeit und Feinstaub mit jenen der Globalstrahlungsdaten zu suchen.Von 2016 bis 2018 korrelieren die Globalstrahlungswerte mit der relativen Luftfeuchtigkeit und den Feinstaubwerten (PM10 und PM2,5). Die engste Beziehung besteht auf der Kuffner-Sternwarte, wo eine Verdoppelung der Luftfeuchtigkeit statistisch von einer Verzehnfachung der Globalstrahlung begleitet wird. Die gefundenen Relationen sind über einen Faktor 100 in der Globalstrahlung äußerst robust und die Koeffizienten der Relationen sind an allen Stationen sehr homogen.Damit stehen gut bestimmte Zusammenhänge zwischen der Luftgüte und dem Zustand der klaren Atmo-sphäre zur Verfügung. Das wird es erlauben, Lichtmessnetze auf Standardatmosphären zu beziehen und damit eine wesentlich bessere Vergleichbarkeit der Daten zu unterschiedlichen Zeitpunkten herzustellen.- 130 Gigawattstunden Jahresaufwand für die Wiener Lichtglocke- 8 Jahre Vermessung der Lichtglocke zeigen Ansätze eines Rückgangs der Lichtflut- Mehr Feinstaub bewirkt überproportional mehr Lichtverschmutzung
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language German Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number GFZ @ kyba @ Serial 2718
Permanent link to this record