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Author (up) Alaimo, A.; Linares, G.G.; Bujjamer, J.M.; Gorojod, R.M.; Alcon, S.P.; Martinez, J.H.; Baldessari, A.; Grecco, H.E.; Kotler, M.L.
Title Toxicity of blue led light and A2E is associated to mitochondrial dynamics impairment in ARPE-19 cells: implications for age-related macular degeneration Type Journal Article
Year 2019 Publication Archives of Toxicology Abbreviated Journal Arch Toxicol
Volume 93 Issue 5 Pages 1401-1415
Keywords Vision; age-related macular degeneration; Eye; Eye Diseases; blue light
Abstract Age-related macular degeneration (AMD) is a multifactorial retinal disease characterized by a progressive loss of central vision. Retinal pigment epithelium (RPE) degeneration is a critical event in AMD. It has been associated to A2E accumulation, which sensitizes RPE to blue light photodamage. Mitochondrial quality control mechanisms have evolved to ensure mitochondrial integrity and preserve cellular homeostasis. Particularly, mitochondrial dynamics involve the regulation of mitochondrial fission and fusion to preserve a healthy mitochondrial network. The present study aims to clarify the cellular and molecular mechanisms underlying photodamage-induced RPE cell death with particular focus on the involvement of defective mitochondrial dynamics. Light-emitting diodes irradiation (445 +/- 18 nm; 4.43 mW/cm(2)) significantly reduced the viability of both unloaded and A2E-loaded human ARPE-19 cells and increased reactive oxygen species production. A2E along with blue light, triggered apoptosis measured by MC540/PI-flow cytometry and activated caspase-3. Blue light induced mitochondrial fusion/fission imbalance towards mitochondrial fragmentation in both non-loaded and A2E-loaded cells which correlated with the deregulation of mitochondria-shaping proteins level (OPA1, DRP1 and OMA1). To our knowledge, this is the first work reporting that photodamage causes mitochondrial dynamics deregulation in RPE cells. This process could possibly contribute to AMD pathology. Our findings suggest that the regulation of mitochondrial dynamics may be a valuable strategy for treating retinal degeneration diseases, such as AMD.
Address Departamento de Quimica Biologica, Facultad de Ciencias Exactas y Naturales, Instituto de Quimica Biologica Ciencias Exactas y Naturales (IQUIBICEN), CONICET-Universidad de Buenos Aires, Pabellon 2, Ciudad Universitaria, 1428, Buenos Aires, Argentina. kotler@qb.fcen.uba.ar
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0340-5761 ISBN Medium
Area Expedition Conference
Notes PMID:30778631 Approved no
Call Number GFZ @ kyba @ Serial 2229
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Author (up) Albala, L.; Bober, T.; Hale, G.; Warfield, B.; Collins, M.L.; Merritt, Z.; Steimetz, E.; Nadler, S.; Lev, Y.; Hanifin, J.
Title Effect on nurse and patient experience: overnight use of blue-depleted illumination Type Journal Article
Year 2019 Publication BMJ Open Quality Abbreviated Journal BMJ Open Qual
Volume 8 Issue 3 Pages e000692
Keywords Human Health
Abstract Background Typical hospital lighting is rich in blue-wavelength emission, which can create unwanted circadian disruption in patients when exposed at night. Despite a growing body of evidence regarding the effects of poor sleep on health outcomes, physiologically neutral technologies have not been widely implemented in the US healthcare system.

Objective The authors sought to determine if rechargeable, proximity-sensing, blue-depleted lighting pods that provide wireless task lighting can make overnight hospital care more efficient for providers and less disruptive to patients.

Design Non-randomised, controlled interventional trial in an intermediate-acuity unit at a large urban medical centre.

Methods Night-time healthcare providers abstained from turning on overhead patient room lighting in favour of a physiologically neutral lighting device. 33 nurses caring for patients on that unit were surveyed after each shift. 21 patients were evaluated after two nights with standard-of-care light and after two nights with lighting intervention.

Results Providers reported a satisfaction score of 8 out of 10, with 82% responding that the lighting pods provided adequate lighting for overnight care tasks. Among patients, a median 2-point improvement on the Hospital Anxiety and Depression Scale was reported.

Conclusion and relevance The authors noted improved caregiver satisfaction and decreased patient anxiety by using a blue-depleted automated task-lighting alternative to overhead room lights. Larger studies are needed to determine the impact of these lighting devices on sleep measures and patient health outcomes like delirium. With the shift to patient-centred financial incentives and emphasis on patient experience, this study points to the feasibility of a physiologically targeted solution for overnight task lighting in healthcare environments.
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 2399-6641 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number GFZ @ kyba @ Serial 2681
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Author (up) Ali A.A.S., Zakaria S.A., Guan A.C.K., Shun C.J.
Title Lighting for Heritage Building: A Case Study of the Lighting Design Applied on St. George’s Church in George Town, Penang Island Type Journal Article
Year 2020 Publication Awang M., Meor M Fared M. (eds) ICACE 2019. Lecture Notes in Civil Engineering Abbreviated Journal
Volume 59 Issue Pages 113-119
Keywords Lighting
Abstract Light is one of the critical aspects of architecture, yet it is one of the understated elements in our daily lives. Light has a significant spot to form events, activities, and memories. Scientific studies have shown that appropriate and proper lighting does not only affect human health but daily human moods as well. Nowadays, lighting fixtures play essential roles in architecture and markets. A proper lighting fixture helps to highlight the structure, textures, and form of the shape of a building. However, the designers tend to focus more on the art aesthetics rather than the conservation ethics, such as the colorful design and the attractive lighting fixtures on the building, while the prime concern should be on realizing the impact of the lighting fixture toward the environment. The objectives of this study are to highlight the issues of the lighting system of the heritage building and suggest some recommendations to meet the requirements for the heritage building for better lighting design. The data for this research was collected using the quantitative method. Thus, as a result, it is found out that lighting design highlights the historical building, and therefore, attracts tourists, which benefit the economy. However, improper lighting installation leads to a negative impact on the society and human health.
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number IDA @ intern @ Serial 2950
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Author (up) Almaida-Pagan, P.F.; Ortega-Sabater, C.; Lucas-Sanchez, A.; Martinez-Nicolas, A.; Espinosa, C.; Esteban, M.A.; Madrid, J.A.; Rol, M.; Mendiola, P.; de Costa, J.
Title Impact of a shift work-like lighting schedule on the functioning of the circadian system in the short-lived fish Nothobranchius furzeri Type Journal Article
Year 2018 Publication Experimental Gerontology Abbreviated Journal Exp Gerontol
Volume in press Issue Pages in press
Keywords Animals
Abstract Adult Nothobranchius furzeri of the MZM-04/10 strain were individually kept and subjected to a “5+2” shifting lighting schedule (SHIFT) for 8weeks in order to evaluate the desynchronizing effects of a simulated human-like shift-work schedule on the functioning of the circadian system (CS). With this aim, sixteen 21-week-old N. furzeri were placed into a Morning, Night and Evening schedule (lights on from 08:00 to 16:00, 00:00 to 08:00 and 16:00 to 00:00h, respectively) and fed once a day in the middle of the corresponding photophase (12:00, 04:00 and 20:00h, respectively). Then, in the weekends (2days), fish were always returned to the Morning shift. As controls, 16 fish were maintained under a non-shifting LD cycle condition (CONTROL) throughout the whole experiment, with lights on from 08:00 to 16:00h. Rest-activity rhythm (RAR) of fish subjected to SHIFT showed several symptoms of chronodisruption, such as a decrease in the percentage of diurnal activity and a reduction of the relative amplitude and the circadian function index with time. When a periodogram analysis was performed, RAR of N. furzeri under SHIFT conditions showed up to three separate circadian components: one longer than 24h (26.5h) that followed the weekly 8h delays; a short-period component (~23h) that was related to the weekend's phase advances, and finally, a 24h component. The shifting LD schedule also affected fish CS at a molecular level, with several significant differences in the expression of core genes of the molecular clock (bmal1, clock, roralpha, rev-erbalpha) between SHIFT and CONTROL animals. RAR impairment along with changes in clock gene expression could be associated with high stress and accelerated aging in these fish.
Address Chronobiology Lab, Department of Physiology, College of Biology, University of Murcia, Mare Nostrum Campus, IUIE, IMIB-Arrixaca, Spain; Ciber Fragilidad y Envejecimiento Saludable (CIBERFES), Madrid, Spain
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0531-5565 ISBN Medium
Area Expedition Conference
Notes PMID:30184464 Approved no
Call Number GFZ @ kyba @ Serial 1999
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Author (up) Alquezar, R.D.; Macedo, R.H.; Sierro, J.; Gil, D.
Title Lack of consistent responses to aircraft noise in dawn song timing of bird populations near tropical airports Type Journal Article
Year 2020 Publication Behavioral Ecology and Sociobiology Abbreviated Journal Behav Ecol Sociobiol
Volume 74 Issue 7 Pages
Keywords Animals
Abstract Birds living near airports can reduce the noise interference by advancing their dawn chorus timing and avoiding the start of airport operations. Data supporting this finding come from temperate areas, but little is known from tropical environments, where seasonal variation is lower and biodiversity is higher. Here, we investigated whether 15 tropical bird species are able to advance their dawn song and avoid aircraft noise interference. We sampled dawn song in three airports and three control sites in Brazil, using automated recording units. We found that dawn song times were not globally affected by the exposure to airport noise. Instead, changes were highly variable and species-specific, as dawn song onset was significantly advanced in two and delayed in four species. This large variation in responses was surprising given patterns found in previous studies. Indeed, this is the first time that a significant delay is reported for bird’s dawn song. We explored whether between-species differences in this response could be explained by additional variables (song frequency, degree of urbanity, and noise release), but none of them explained the direction or the strength of the changes. We suggest that earlier airport activity and shorter variations in day length and in twilight duration of tropical areas may be restricting birds’ ability to change dawn song timing. Further studies should consider these differences and analyze to what extent populational declines in noisy areas and the resultant reduced competition for acoustic space may be affecting the changes in dawn chorus onset time.
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0340-5443 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number GFZ @ kyba @ Serial 3017
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