| Records |
| Author |
Xiang, S.; Dauchy, R.T.; Hoffman, A.E.; Pointer, D.; Frasch, T.; Blask, D.E.; Hill, S.M. |
| Title |
Epigenetic inhibition of the tumor suppressor ARHI by light at night-induced circadian melatonin disruption mediates STAT3-driven paclitaxel resistance in breast cancer |
Type |
Journal Article |
| Year |
2019 |
Publication |
Journal of Pineal Research |
Abbreviated Journal |
J Pineal Res |
| Volume |
in press |
Issue |
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Pages  |
e12586 |
| Keywords |
Animals; Human Health |
| Abstract |
Disruption of circadian time structure and suppression of circadian nocturnal melatonin (MLT) production by exposure to dim light at night (dLAN), as occurs with night shift work and/or disturbed sleep-wake cycles, is associated with a significantly increased risk of breast cancer and resistance to tamoxifen and doxorubicin. Melatonin inhibition of human breast cancer chemo-resistance involves mechanisms including suppression of tumor metabolism and inhibition of kinases and transcription factors which are often activated in drug-resistant breast cancer. Signal Transducer and Activator of Transcription 3 (STAT3), frequently overexpressed and activated in Paclitaxel (PTX)-resistant breast cancer, promotes the expression of DNA methyltransferase one (DNMT1) to epigenetically suppresses the transcription of tumor suppressor Aplasia Ras homolog one (ARHI) which can sequester STAT3 in the cytoplasm to block PTX-resistance. We demonstrate that breast tumor xenografts in rats exposed to dLAN and circadian MLT disrupted express elevated levels of phosphorylated and acetylated STAT3, increased DNMT1, but reduced Sirtuin 1 (SIRT1) and ARHI. Furthermore, MLT and/or SIRT1 administration blocked/reversed Interleukin 6 (IL-6)-induced acetylation of STAT3 and its methylation of ARH1 to increase ARH1 mRNA expression in MCF-7 breast cancer cells. Finally, analyses of the I-SPY 1 trial demonstrates that elevated MT1 receptor expression is significantly correlated with pathologic complete response following neo-adjuvant therapy in breast cancer patients. This is the first study to demonstrate circadian disruption of MLT by dLAN driving intrinsic resistance to PTX via epigenetic mechanisms increasing STAT3 expression and that MLT administration can reestablish sensitivity of breast tumors to PTX and drive tumor regression. This article is protected by copyright. All rights reserved. |
| Address |
Tulane Circadian Cancer Biology Group, New Orleans, Louisiana |
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English |
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0742-3098 |
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| Notes |
PMID:31077613 |
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no |
| Call Number |
GFZ @ kyba @ |
Serial |
2383 |
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| Author |
Muztaba, R.; Saryantono, B.; Putri, A.N.I.; Pratiwi, T.D. |
| Title |
Zenithal sky glow measurement in Bandar Lampung as consideration in drafting the regulation of light pollution-free areas around the Lampung Astronomical Observatory (LAO) |
Type |
Journal Article |
| Year |
2019 |
Publication |
Journal of Physics: Conference Series |
Abbreviated Journal |
J. Phys.: Conf. Ser. |
| Volume |
1231 |
Issue |
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Pages |
012023 |
| Keywords |
Skyglow |
| Abstract |
Urban development to big cities generally will be accompanied by excessive use of artificial light, such as street lamps, billboards, and building lighting systems. Ineffective and incorrect lighting installation design causes environmental degradation, i.e light pollution. Today, light pollution is one indicator of environmental degradation and energy waste behavior. Study on light pollution has progressed in many fields of science, extending from traditional fields of astronomy to atmospheric physics, environmental science, natural science, and social life. Measurement of sky brightness is also an indicator of the feasibility of an observatory development plan. The location of the observatory is located at coordinates latitude -05° 27' 71'' and longitude 105° 09' 39'' with a height of 1030 above mean sea level. The construction of an observatory requires a study of the sky's brightness conditions as a matter of consideration to obtain the best observation result. Therefore, to support the Lampung Provincial Government, Institut Teknologi Sumatera (ITERA) and Institut Teknologi Bandung (ITB) in carrying out the construction of observatories in TAHURA WAR, Gunung Betung, Lampung. We did the sky brightness measurements as far as 15 km from the location point of the observatory. We use SQM to measure the brightness of the sky towards the zenith in every crowded area in the city of Bandar Lampung. Then, from the measurement results, we make a map of light pollution. From the mapping results, there are four locations that are indicated to be contaminated by light pollution, namely Tanjung Senang, Teluk Betung, Kemiling, and Gedong Tataan with respective values of 15.8 mpas, 16.6 mpas, 16.8 mpas, and 17.00 mpas. |
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1742-6588 |
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GFZ @ kyba @ |
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2569 |
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| Author |
Admiranto, A.G.; Priyatikanto, R.; Maryam, S.; Ellyyani,; Suryana, N. |
| Title |
Preliminary Report of Light Pollution in Indonesia Based on Sky Quality Observation |
Type |
Journal Article |
| Year |
2019 |
Publication |
Journal of Physics: Conference Series |
Abbreviated Journal |
J. Phys.: Conf. Ser. |
| Volume |
1231 |
Issue |
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Pages |
012017 |
| Keywords |
Skyglow |
| Abstract |
We observed night sky quality in several LAPAN stations (Agam, Bandung, Pontianak, Sumedang, Garut, Pasuruan, and Biak) which were conducted from April until July 2018 using Unihedron Sky Quality Meter LU-DL type. Observational data from all of the observational points were then sent regularly to a centralized database for further use. Although most of the measurements were done in overcast conditions, we were able to determine the representative clear sky brightness statistically. The results showed that the light pollution level of the most of the stations are moderate (the values at Biak, Agam, Sumedang, and Pontianak are 20.0, 19.5, 19.6, and 17.7 mpsas respectively) and the stations which are located near or in cities are high (Bandung and Pasuruan with 17.1 and 18.0 mpsas, respectively). In a particular station (Garut) the light pollution is low (20.6 mpsas), so it is good to make this spot to be a location of astrotourism. |
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1742-6588 |
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no |
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GFZ @ kyba @ |
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2570 |
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| Author |
Prastyo, H.A.; Herdiwijaya, D. |
| Title |
Spatial Analysis of Light Pollution Dynamics Around Bosscha Observatory and Timau National Observatory Based on VIIRS-DNB Satellite Images |
Type |
Journal Article |
| Year |
2019 |
Publication |
Journal of Physics: Conference Series |
Abbreviated Journal |
J. Phys.: Conf. Ser. |
| Volume |
1231 |
Issue |
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Pages |
012002 |
| Keywords |
Remote Sensing |
| Abstract |
Bosscha Observatory is the largest and oldest observatory in Indonesia that has been actively doing astronomical research since 1928. Bosscha Observatory was originally very suitable for observing astronomical objects because of its ideal night sky conditions and covered most of the northern and southern sky areas. However, starting at the end of 1980, the quality of the night sky at Bosscha Observatory has decreased along with the development of cities around the observatory. Therefore, the construction of a new observatory in Indonesia is currently underway, i.e. the Timau National Observatory. One of the main causes of the decreasing quality of the night sky at Bosscha Observatory is light pollution. Light pollution is one form of pollution caused by excessive light outside the room released into the sky, causing an increase in brightness of the night sky. The brightness increasing of the night sky causes relatively faint astronomical object, e.g. Milky Way Galaxy that is difficult to observe. Based on the analysis of the dynamics of light pollution in a radius of 20 km from Bosscha Observatory and at a radius of 90 km from the Timau National Observatory in 2013-2017 using VIIRS-DNB satellite imagery, it is known that there is a wide change in light pollution for the very low, low, medium, high, and very high. The average area of light pollution at a radius of 20 km from Bosscha Observatory for the category of very low, low, medium, high, and very high categories experienced a rate of -41.3 ± 135.2 km2 / year, 5.9 ± 97.2 km2 / year, 15.1 ± 14.6 km2 / year, 18.0 ± 42.6 km2 / year, and 2.1 ± 10.2 km2 / year. The rate of increase in the extent of light pollution for the medium, high, and very high categories occurs south of the Bosscha Observatory, which is towards the city of Bandung. The average area of light pollution in a 90 km radius from the Timau National Observatory for the very low, low, medium, and high categories experienced a rate of 20.8 ± 43.4 km2 / year, -22.1 ± 40.9 km2 / year, 3.0 ± 7.3 km2 / year, and -1.7 ± 7.3 km2 / year. Therefore, the night sky in the 128-268 degrees azimuth direction at Bosscha Observatory is relatively not ideal as a location for observing astronomical objects, and the Timau National Observatory is still relatively ideal as a location for observing astronomical objects, but it is necessary to monitor the dynamics of light pollution in the direction of 207-215 degrees azimuth which leads to Kupang City. |
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1742-6588 |
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no |
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GFZ @ kyba @ |
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2568 |
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| Author |
Rezky, M.; Priyatikanto, R.; Admiranto, A.G.; Soegiartini, E. |
| Title |
Pattern recognition as tools for understanding night sky brightness variabilities |
Type |
Journal Article |
| Year |
2019 |
Publication |
Journal of Physics: Conference Series |
Abbreviated Journal |
J. Phys.: Conf. Ser. |
| Volume |
1231 |
Issue |
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Pages |
012001 |
| Keywords |
Skyglow |
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1742-6588 |
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GFZ @ kyba @ |
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2565 |
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