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Author Mishra, I.; Knerr, R.M.; Stewart, A.A.; Payette, W.I.; Richter, M.M.; Ashley, N.T. url  doi
openurl 
  Title Light at night disrupts diel patterns of cytokine gene expression and endocrine profiles in zebra finch (Taeniopygia guttata) Type Journal Article
  Year 2019 Publication Scientific Reports Abbreviated Journal Sci Rep  
  Volume 9 Issue 1 Pages (down) 15833  
  Keywords Animals  
  Abstract Increased exposure to light pollution perturbs physiological processes through misalignment of daily rhythms at the cellular and tissue levels. Effects of artificial light-at-night (ALAN) on diel properties of immunity are currently unknown. We therefore tested the effects of ALAN on diel patterns of cytokine gene expression, as well as key hormones involved with the regulation of immunity, in zebra finches (Taeniopygia guttata). Circulating melatonin and corticosterone, and mRNA expression levels of pro- (IL-1beta, IL-6) and anti-inflammatory (IL-10) cytokines were measured at six time points across 24-h day in brain (nidopallium, hippocampus, and hypothalamus) and peripheral tissues (liver, spleen, and fat) of zebra finches exposed to 12 h light:12 h darkness (LD), dim light-at-night (DLAN) or constant bright light (LLbright). Melatonin and corticosterone concentrations were significantly rhythmic under LD, but not under LLbright and DLAN. Genes coding for cytokines showed tissue-specific diurnal rhythms under LD and were lost with exposure to LLbright, except IL-6 in hypothalamus and liver. In comparison to LLbright, effects of DLAN were less adverse with persistence of some diurnal rhythms, albeit with significant waveform alterations. These results underscore the circadian regulation of biosynthesis of immune effectors and imply the susceptibility of daily immune and endocrine patterns to ALAN.  
  Address Department of Biology, Western Kentucky University, Bowling Green, KY, USA. noah.ashley@wku.edu  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 2045-2322 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:31676761; PMCID:PMC6825233 Approved no  
  Call Number GFZ @ kyba @ Serial 2766  
Permanent link to this record
 

 
Author Xiang, S.; Dauchy, R.T.; Hoffman, A.E.; Pointer, D.; Frasch, T.; Blask, D.E.; Hill, S.M. url  doi
openurl 
  Title Epigenetic inhibition of the tumor suppressor ARHI by light at night-induced circadian melatonin disruption mediates STAT3-driven paclitaxel resistance in breast cancer Type Journal Article
  Year 2019 Publication Journal of Pineal Research Abbreviated Journal J Pineal Res  
  Volume in press Issue Pages (down) e12586  
  Keywords Animals; Human Health  
  Abstract Disruption of circadian time structure and suppression of circadian nocturnal melatonin (MLT) production by exposure to dim light at night (dLAN), as occurs with night shift work and/or disturbed sleep-wake cycles, is associated with a significantly increased risk of breast cancer and resistance to tamoxifen and doxorubicin. Melatonin inhibition of human breast cancer chemo-resistance involves mechanisms including suppression of tumor metabolism and inhibition of kinases and transcription factors which are often activated in drug-resistant breast cancer. Signal Transducer and Activator of Transcription 3 (STAT3), frequently overexpressed and activated in Paclitaxel (PTX)-resistant breast cancer, promotes the expression of DNA methyltransferase one (DNMT1) to epigenetically suppresses the transcription of tumor suppressor Aplasia Ras homolog one (ARHI) which can sequester STAT3 in the cytoplasm to block PTX-resistance. We demonstrate that breast tumor xenografts in rats exposed to dLAN and circadian MLT disrupted express elevated levels of phosphorylated and acetylated STAT3, increased DNMT1, but reduced Sirtuin 1 (SIRT1) and ARHI. Furthermore, MLT and/or SIRT1 administration blocked/reversed Interleukin 6 (IL-6)-induced acetylation of STAT3 and its methylation of ARH1 to increase ARH1 mRNA expression in MCF-7 breast cancer cells. Finally, analyses of the I-SPY 1 trial demonstrates that elevated MT1 receptor expression is significantly correlated with pathologic complete response following neo-adjuvant therapy in breast cancer patients. This is the first study to demonstrate circadian disruption of MLT by dLAN driving intrinsic resistance to PTX via epigenetic mechanisms increasing STAT3 expression and that MLT administration can reestablish sensitivity of breast tumors to PTX and drive tumor regression. This article is protected by copyright. All rights reserved.  
  Address Tulane Circadian Cancer Biology Group, New Orleans, Louisiana  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0742-3098 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:31077613 Approved no  
  Call Number GFZ @ kyba @ Serial 2383  
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Author Muztaba, R.; Saryantono, B.; Putri, A.N.I.; Pratiwi, T.D. url  doi
openurl 
  Title Zenithal sky glow measurement in Bandar Lampung as consideration in drafting the regulation of light pollution-free areas around the Lampung Astronomical Observatory (LAO) Type Journal Article
  Year 2019 Publication Journal of Physics: Conference Series Abbreviated Journal J. Phys.: Conf. Ser.  
  Volume 1231 Issue Pages (down) 012023  
  Keywords Skyglow  
  Abstract Urban development to big cities generally will be accompanied by excessive use of artificial light, such as street lamps, billboards, and building lighting systems. Ineffective and incorrect lighting installation design causes environmental degradation, i.e light pollution. Today, light pollution is one indicator of environmental degradation and energy waste behavior. Study on light pollution has progressed in many fields of science, extending from traditional fields of astronomy to atmospheric physics, environmental science, natural science, and social life. Measurement of sky brightness is also an indicator of the feasibility of an observatory development plan. The location of the observatory is located at coordinates latitude -05° 27' 71'' and longitude 105° 09' 39'' with a height of 1030 above mean sea level. The construction of an observatory requires a study of the sky's brightness conditions as a matter of consideration to obtain the best observation result. Therefore, to support the Lampung Provincial Government, Institut Teknologi Sumatera (ITERA) and Institut Teknologi Bandung (ITB) in carrying out the construction of observatories in TAHURA WAR, Gunung Betung, Lampung. We did the sky brightness measurements as far as 15 km from the location point of the observatory. We use SQM to measure the brightness of the sky towards the zenith in every crowded area in the city of Bandar Lampung. Then, from the measurement results, we make a map of light pollution. From the mapping results, there are four locations that are indicated to be contaminated by light pollution, namely Tanjung Senang, Teluk Betung, Kemiling, and Gedong Tataan with respective values of 15.8 mpas, 16.6 mpas, 16.8 mpas, and 17.00 mpas.  
  Address  
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  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1742-6588 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number GFZ @ kyba @ Serial 2569  
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Author Admiranto, A.G.; Priyatikanto, R.; Maryam, S.; Ellyyani,; Suryana, N. url  doi
openurl 
  Title Preliminary Report of Light Pollution in Indonesia Based on Sky Quality Observation Type Journal Article
  Year 2019 Publication Journal of Physics: Conference Series Abbreviated Journal J. Phys.: Conf. Ser.  
  Volume 1231 Issue Pages (down) 012017  
  Keywords Skyglow  
  Abstract We observed night sky quality in several LAPAN stations (Agam, Bandung, Pontianak, Sumedang, Garut, Pasuruan, and Biak) which were conducted from April until July 2018 using Unihedron Sky Quality Meter LU-DL type. Observational data from all of the observational points were then sent regularly to a centralized database for further use. Although most of the measurements were done in overcast conditions, we were able to determine the representative clear sky brightness statistically. The results showed that the light pollution level of the most of the stations are moderate (the values at Biak, Agam, Sumedang, and Pontianak are 20.0, 19.5, 19.6, and 17.7 mpsas respectively) and the stations which are located near or in cities are high (Bandung and Pasuruan with 17.1 and 18.0 mpsas, respectively). In a particular station (Garut) the light pollution is low (20.6 mpsas), so it is good to make this spot to be a location of astrotourism.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1742-6588 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number GFZ @ kyba @ Serial 2570  
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Author Prastyo, H.A.; Herdiwijaya, D. url  doi
openurl 
  Title Spatial Analysis of Light Pollution Dynamics Around Bosscha Observatory and Timau National Observatory Based on VIIRS-DNB Satellite Images Type Journal Article
  Year 2019 Publication Journal of Physics: Conference Series Abbreviated Journal J. Phys.: Conf. Ser.  
  Volume 1231 Issue Pages (down) 012002  
  Keywords Remote Sensing  
  Abstract Bosscha Observatory is the largest and oldest observatory in Indonesia that has been actively doing astronomical research since 1928. Bosscha Observatory was originally very suitable for observing astronomical objects because of its ideal night sky conditions and covered most of the northern and southern sky areas. However, starting at the end of 1980, the quality of the night sky at Bosscha Observatory has decreased along with the development of cities around the observatory. Therefore, the construction of a new observatory in Indonesia is currently underway, i.e. the Timau National Observatory. One of the main causes of the decreasing quality of the night sky at Bosscha Observatory is light pollution. Light pollution is one form of pollution caused by excessive light outside the room released into the sky, causing an increase in brightness of the night sky. The brightness increasing of the night sky causes relatively faint astronomical object, e.g. Milky Way Galaxy that is difficult to observe. Based on the analysis of the dynamics of light pollution in a radius of 20 km from Bosscha Observatory and at a radius of 90 km from the Timau National Observatory in 2013-2017 using VIIRS-DNB satellite imagery, it is known that there is a wide change in light pollution for the very low, low, medium, high, and very high. The average area of light pollution at a radius of 20 km from Bosscha Observatory for the category of very low, low, medium, high, and very high categories experienced a rate of -41.3 ± 135.2 km2 / year, 5.9 ± 97.2 km2 / year, 15.1 ± 14.6 km2 / year, 18.0 ± 42.6 km2 / year, and 2.1 ± 10.2 km2 / year. The rate of increase in the extent of light pollution for the medium, high, and very high categories occurs south of the Bosscha Observatory, which is towards the city of Bandung. The average area of light pollution in a 90 km radius from the Timau National Observatory for the very low, low, medium, and high categories experienced a rate of 20.8 ± 43.4 km2 / year, -22.1 ± 40.9 km2 / year, 3.0 ± 7.3 km2 / year, and -1.7 ± 7.3 km2 / year. Therefore, the night sky in the 128-268 degrees azimuth direction at Bosscha Observatory is relatively not ideal as a location for observing astronomical objects, and the Timau National Observatory is still relatively ideal as a location for observing astronomical objects, but it is necessary to monitor the dynamics of light pollution in the direction of 207-215 degrees azimuth which leads to Kupang City.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1742-6588 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number GFZ @ kyba @ Serial 2568  
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