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Author Te Kulve, M.; Schlangen, L.J.M.; van Marken Lichtenbelt, W.D.
Title Early evening light mitigates sleep compromising physiological and alerting responses to subsequent late evening light Type Journal Article
Year 2019 Publication Scientific Reports Abbreviated Journal Sci Rep
Volume 9 Issue 1 Pages (down) 16064
Keywords Human Health
Abstract The widespread use of electric light and electronic devices has resulted in an excessive exposure to light during the late-evening and at night. This late light exposure acutely suppresses melatonin and sleepiness and delays the circadian clock. Here we investigate whether the acute effects of late-evening light exposure on our physiology and sleepiness are reduced when this light exposure is preceded by early evening bright light. Twelve healthy young females were included in a randomised crossover study. All participants underwent three evening (18:30-00:30) sessions during which melatonin, subjective sleepiness, body temperature and skin blood flow were measured under different light conditions: (A) dim light, (B) dim light with a late-evening (22:30-23:30) light exposure of 750 lx, 4000 K, and (C) the same late-evening light exposure, but now preceded by early-evening bright light exposure (18.30-21.00; 1200 lx, 4000 K). Late-evening light exposure reduced melatonin levels and subjective sleepiness and resulted in larger skin temperature gradients as compared to dim. Interestingly, these effects were reduced when the late-evening light was preceded by an early evening 2.5-hour bright light exposure. Thus daytime and early-evening exposure to bright light can mitigate some of the sleep-disruptive consequences of light exposure in the later evening.
Address Department of Human Biology & Movement Sciences, NUTRIM, Maastricht University, Maastricht, The Netherlands
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 2045-2322 ISBN Medium
Area Expedition Conference
Notes PMID:31690740; PMCID:PMC6831674 Approved no
Call Number GFZ @ kyba @ Serial 2751
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Author Xiang, S.; Dauchy, R.T.; Hoffman, A.E.; Pointer, D.; Frasch, T.; Blask, D.E.; Hill, S.M.
Title Epigenetic inhibition of the tumor suppressor ARHI by light at night-induced circadian melatonin disruption mediates STAT3-driven paclitaxel resistance in breast cancer Type Journal Article
Year 2019 Publication Journal of Pineal Research Abbreviated Journal J Pineal Res
Volume in press Issue Pages (down) e12586
Keywords Animals; Human Health
Abstract Disruption of circadian time structure and suppression of circadian nocturnal melatonin (MLT) production by exposure to dim light at night (dLAN), as occurs with night shift work and/or disturbed sleep-wake cycles, is associated with a significantly increased risk of breast cancer and resistance to tamoxifen and doxorubicin. Melatonin inhibition of human breast cancer chemo-resistance involves mechanisms including suppression of tumor metabolism and inhibition of kinases and transcription factors which are often activated in drug-resistant breast cancer. Signal Transducer and Activator of Transcription 3 (STAT3), frequently overexpressed and activated in Paclitaxel (PTX)-resistant breast cancer, promotes the expression of DNA methyltransferase one (DNMT1) to epigenetically suppresses the transcription of tumor suppressor Aplasia Ras homolog one (ARHI) which can sequester STAT3 in the cytoplasm to block PTX-resistance. We demonstrate that breast tumor xenografts in rats exposed to dLAN and circadian MLT disrupted express elevated levels of phosphorylated and acetylated STAT3, increased DNMT1, but reduced Sirtuin 1 (SIRT1) and ARHI. Furthermore, MLT and/or SIRT1 administration blocked/reversed Interleukin 6 (IL-6)-induced acetylation of STAT3 and its methylation of ARH1 to increase ARH1 mRNA expression in MCF-7 breast cancer cells. Finally, analyses of the I-SPY 1 trial demonstrates that elevated MT1 receptor expression is significantly correlated with pathologic complete response following neo-adjuvant therapy in breast cancer patients. This is the first study to demonstrate circadian disruption of MLT by dLAN driving intrinsic resistance to PTX via epigenetic mechanisms increasing STAT3 expression and that MLT administration can reestablish sensitivity of breast tumors to PTX and drive tumor regression. This article is protected by copyright. All rights reserved.
Address Tulane Circadian Cancer Biology Group, New Orleans, Louisiana
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0742-3098 ISBN Medium
Area Expedition Conference
Notes PMID:31077613 Approved no
Call Number GFZ @ kyba @ Serial 2383
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Author Muztaba, R.; Saryantono, B.; Putri, A.N.I.; Pratiwi, T.D.
Title Zenithal sky glow measurement in Bandar Lampung as consideration in drafting the regulation of light pollution-free areas around the Lampung Astronomical Observatory (LAO) Type Journal Article
Year 2019 Publication Journal of Physics: Conference Series Abbreviated Journal J. Phys.: Conf. Ser.
Volume 1231 Issue Pages (down) 012023
Keywords Skyglow
Abstract Urban development to big cities generally will be accompanied by excessive use of artificial light, such as street lamps, billboards, and building lighting systems. Ineffective and incorrect lighting installation design causes environmental degradation, i.e light pollution. Today, light pollution is one indicator of environmental degradation and energy waste behavior. Study on light pollution has progressed in many fields of science, extending from traditional fields of astronomy to atmospheric physics, environmental science, natural science, and social life. Measurement of sky brightness is also an indicator of the feasibility of an observatory development plan. The location of the observatory is located at coordinates latitude -05° 27' 71'' and longitude 105° 09' 39'' with a height of 1030 above mean sea level. The construction of an observatory requires a study of the sky's brightness conditions as a matter of consideration to obtain the best observation result. Therefore, to support the Lampung Provincial Government, Institut Teknologi Sumatera (ITERA) and Institut Teknologi Bandung (ITB) in carrying out the construction of observatories in TAHURA WAR, Gunung Betung, Lampung. We did the sky brightness measurements as far as 15 km from the location point of the observatory. We use SQM to measure the brightness of the sky towards the zenith in every crowded area in the city of Bandar Lampung. Then, from the measurement results, we make a map of light pollution. From the mapping results, there are four locations that are indicated to be contaminated by light pollution, namely Tanjung Senang, Teluk Betung, Kemiling, and Gedong Tataan with respective values of 15.8 mpas, 16.6 mpas, 16.8 mpas, and 17.00 mpas.
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1742-6588 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number GFZ @ kyba @ Serial 2569
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Author Admiranto, A.G.; Priyatikanto, R.; Maryam, S.; Ellyyani,; Suryana, N.
Title Preliminary Report of Light Pollution in Indonesia Based on Sky Quality Observation Type Journal Article
Year 2019 Publication Journal of Physics: Conference Series Abbreviated Journal J. Phys.: Conf. Ser.
Volume 1231 Issue Pages (down) 012017
Keywords Skyglow
Abstract We observed night sky quality in several LAPAN stations (Agam, Bandung, Pontianak, Sumedang, Garut, Pasuruan, and Biak) which were conducted from April until July 2018 using Unihedron Sky Quality Meter LU-DL type. Observational data from all of the observational points were then sent regularly to a centralized database for further use. Although most of the measurements were done in overcast conditions, we were able to determine the representative clear sky brightness statistically. The results showed that the light pollution level of the most of the stations are moderate (the values at Biak, Agam, Sumedang, and Pontianak are 20.0, 19.5, 19.6, and 17.7 mpsas respectively) and the stations which are located near or in cities are high (Bandung and Pasuruan with 17.1 and 18.0 mpsas, respectively). In a particular station (Garut) the light pollution is low (20.6 mpsas), so it is good to make this spot to be a location of astrotourism.
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1742-6588 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number GFZ @ kyba @ Serial 2570
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Author Prastyo, H.A.; Herdiwijaya, D.
Title Spatial Analysis of Light Pollution Dynamics Around Bosscha Observatory and Timau National Observatory Based on VIIRS-DNB Satellite Images Type Journal Article
Year 2019 Publication Journal of Physics: Conference Series Abbreviated Journal J. Phys.: Conf. Ser.
Volume 1231 Issue Pages (down) 012002
Keywords Remote Sensing
Abstract Bosscha Observatory is the largest and oldest observatory in Indonesia that has been actively doing astronomical research since 1928. Bosscha Observatory was originally very suitable for observing astronomical objects because of its ideal night sky conditions and covered most of the northern and southern sky areas. However, starting at the end of 1980, the quality of the night sky at Bosscha Observatory has decreased along with the development of cities around the observatory. Therefore, the construction of a new observatory in Indonesia is currently underway, i.e. the Timau National Observatory. One of the main causes of the decreasing quality of the night sky at Bosscha Observatory is light pollution. Light pollution is one form of pollution caused by excessive light outside the room released into the sky, causing an increase in brightness of the night sky. The brightness increasing of the night sky causes relatively faint astronomical object, e.g. Milky Way Galaxy that is difficult to observe. Based on the analysis of the dynamics of light pollution in a radius of 20 km from Bosscha Observatory and at a radius of 90 km from the Timau National Observatory in 2013-2017 using VIIRS-DNB satellite imagery, it is known that there is a wide change in light pollution for the very low, low, medium, high, and very high. The average area of light pollution at a radius of 20 km from Bosscha Observatory for the category of very low, low, medium, high, and very high categories experienced a rate of -41.3 ± 135.2 km2 / year, 5.9 ± 97.2 km2 / year, 15.1 ± 14.6 km2 / year, 18.0 ± 42.6 km2 / year, and 2.1 ± 10.2 km2 / year. The rate of increase in the extent of light pollution for the medium, high, and very high categories occurs south of the Bosscha Observatory, which is towards the city of Bandung. The average area of light pollution in a 90 km radius from the Timau National Observatory for the very low, low, medium, and high categories experienced a rate of 20.8 ± 43.4 km2 / year, -22.1 ± 40.9 km2 / year, 3.0 ± 7.3 km2 / year, and -1.7 ± 7.3 km2 / year. Therefore, the night sky in the 128-268 degrees azimuth direction at Bosscha Observatory is relatively not ideal as a location for observing astronomical objects, and the Timau National Observatory is still relatively ideal as a location for observing astronomical objects, but it is necessary to monitor the dynamics of light pollution in the direction of 207-215 degrees azimuth which leads to Kupang City.
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1742-6588 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number GFZ @ kyba @ Serial 2568
Permanent link to this record