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Author Yue, F.; Xia, K.; Wei, L.; Xing, L.; Wu, S.; Shi, Y.; Man, L.S.; Shui, G.; Xiang, X.; Russell, R.; Zhang, D. url  doi
openurl 
  Title Constant light exposure causes dysregulation of sphingolipids and promotes steatohepatitis in high-fat fed rats Type Journal Article
  Year 2020 Publication Journal of Gastroenterology and Hepatology Abbreviated Journal J Gastroenterol Hepatol  
  Volume in press Issue Pages (up)  
  Keywords Animals; apoptosis; ceramide; light pollution; non-alcoholic fatty liver disease; sphingolipids  
  Abstract BACKGROUND AND AIM: Non-alcoholic fatty liver disease (NAFLD) is a growing public health concern worldwide. With the progression of urbanization, light pollution is becoming an inevitable risk factor for NAFLD. However, the role of light pollution on NAFLD is insufficiently understood, and the underlying mechanism remains unclear. The present study explored effects of constant light exposure on NAFLD and elucidated its related mechanisms. METHODS: Thirty-two male SD rats were divided into 4 groups (n=8 each): 1) rats on a normal diet exposed to standard light-dark cycle (ND-LD); 2) rats on a normal diet exposed to constant light (ND-LL); 3) rats on a high fat diet exposed to standard light-dark cycle (HFD-LD); 4) and rats on a high fat diet exposed to constant light (HFD-LL). After 12 weeks treatment, rats were sacrificed and pathophysiological assessments were performed. Targeted lipidomics was used to measure sphingolipids, including ceramides, glucosylceramides and lactosylceramides, sphingomyelins and sphingosine-1-phosphates in plasma and liver tissues. RESULTS: In normal chow rats, constant light exposure led to glucose abnormalities and dyslipidemia. In high-fat fed rats, constant light exposure exacerbated glucose abnormalities, dyslipidemia, insulin resistance, inflammation and aggravated steatohepatitis. Compared to HFD-LD rats, HFD-LL had decreased plasma sphingosine-1-phosphate and elevated liver concentrations of total ceramides and specific ceramide species (ceramide d18:0/24:0, ceramide d18:1/22:0, ceramide d18:1/24:0 and ceramide d18:1/24:1), and which were associated with increased hepatocyte apoptosis. CONCLUSIONS: Constant light exposure causes dysregulation of sphingolipids and promotes steatohepatitis in high-fat fed rats.  
  Address Department of Endocrinology, Xiangya Hospital, Central South University, Changsha, Hunan, China  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0815-9319 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:32027419 Approved no  
  Call Number GFZ @ kyba @ Serial 2829  
Permanent link to this record
 

 
Author Wu, Y.; Jiang, M.; Chang, Z.; Li, Y.; Shi, K. url  doi
openurl 
  Title Does China's Urban Development Satisfy Zipf's Law? A Multiscale Perspective from the NPP-VIIRS Nighttime Light Data Type Journal Article
  Year 2020 Publication International Journal of Environmental Research and Public Health Abbreviated Journal Int J Environ Res Public Health  
  Volume 17 Issue 4 Pages (up)  
  Keywords Remote Sensing; China; Zipf's law; multiscale analysis; nighttime lights; urban development  
  Abstract Currently, whether the urban development in China satisfies Zipf's law across different scales is still unclear. Thus, this study attempted to explore whether China's urban development satisfies Zipf's law across different scales from the National Polar-Orbiting Partnership's Visible Infrared Imaging Radiometer Suite (NPP-VIIRS) nighttime light data. First, the NPP-VIIRS data were corrected. Then, based on the Zipf law model, the corrected NPP-VIIRS data were used to evaluate China's urban development at multiple scales. The results showed that the corrected NPP-VIIRS data could effectively reflect the state of urban development in China. Additionally, the Zipf index (q) values, which could express the degree of urban development, decreased from 2012 to 2018 overall in all provinces, prefectures, and counties. Since the value of q was relatively close to 1 with an R(2) value > 0.70, the development of the provinces and prefectures was close to the ideal Zipf's law state. In all counties, q > 1 with an R(2) value > 0.70, which showed that the primate county had a relatively stronger monopoly capacity. When the value of q < 1 with a continuous declination in the top 2000 counties, the top 250 prefectures, and the top 20 provinces in equilibrium, there was little difference in the scale of development at the multiscale level with an R(2) > 0.90. The results enriched our understanding of urban development in terms of Zipf's law and had valuable implications for relevant decision-makers and stakeholders.  
  Address Chongqing Engineering Research Centre for Remote Sensing Big Data Application, School of Geographical Sciences, Southwest University, Chongqing 400715, China  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1660-4601 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:32102480 Approved no  
  Call Number GFZ @ kyba @ Serial 2832  
Permanent link to this record
 

 
Author Qiang, Y.; Huang, Q.; Xu, J. url  doi
openurl 
  Title Observing Community Resilience from Space: Using Nighttime Lights to Model Economic Disturbance and Recovery Pattern in Natural Disaster Type Journal Article
  Year 2020 Publication Sustainable Cities and Society Abbreviated Journal Sustainable Cities and Society  
  Volume in press Issue Pages (up)  
  Keywords Remote Sensing  
  Abstract A major challenge for measuring community resilience is the lack of empirical observation in disasters. As an effective tool for observing human activities on the earth surface, night-time light (NTL) remote sensing images can fill the gap of empirical data for measuring community resilience in natural disasters. This study introduces a quantitative framework to model the recovery pattern of economic activity in a natural disaster using the Defense Meteorological Satellite Program-Operational Linescan System (DMSP-OLS) images. The utility of the framework is demonstrated in a case study of Hurricane Katrina, which uncovered the great economic impact of Katrina and spatial variation of the disturbance and recovery pattern of economic activity. Environmental and socio-economic factors that potentially influence the economic recovery were explored in statistical analyses. Instead of a static and holistic index, the framework measures resilience as a dynamic process. The analysis results provide actionable information for prompting resilience in diverse communities and in different phases of a disaster. In addition to Hurricane Katrina, the resilience modeling framework is applicable for other disaster types. The introduced approaches and findings increase our understanding about the complexity of community resilience and provide support for developing resilient and sustainable communities.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 2210-6707 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number GFZ @ kyba @ Serial 2833  
Permanent link to this record
 

 
Author Marchant, P.; Hale, J.D.; Sadler, J.P. url  doi
openurl 
  Title Does changing to brighter road lighting improve road safety? Multilevel longitudinal analysis of road traffic collision frequency during the relighting of a UK city Type Journal Article
  Year 2020 Publication Journal of Epidemiology & Community Health Abbreviated Journal J. Epidemiol. Community Health  
  Volume Issue Pages (up)  
  Keywords Public Safety; traffic safety; Roadway lighting; road safety; road traffic collisions; United Kingdom  
  Abstract Background A step change in the night environment is taking place, with the large-scale installation of bright, broad-spectrum road lighting such as white light-emitting diodes (LEDs). One justification for this is a reduction in road traffic collisions (RTCs). This study aimed to estimate the effect of new lighting on personal injury RTCs within a large UK city.

Methods We analysed a 9-year time series of weekly RTC personal injury counts in 132 areas of the city using multilevel modelling. The RTC rate over a full 24-hour period was the primary outcome; darkness and daylight RTC rates were secondary. The background change in RTC rate was separated from the change associated with the number of newly installed bright lamps by including a polynomial underlying time trend for the logarithm of the mean number of collisions per week for each area. The study was based on a rigorous, predesigned and archived protocol.

Results Within-area coefficients for the broad lighting effect were positive; as the number of bright lamps in an area increased, so did the RTC rate. The estimate for the increase in the within-area 24-hour RTC rate is 11% (95% CI 2% to 20%). The estimate of darkness-only RTCs is 16% (95% CI 2% to 32%). If the effect of lighting on darkness RTC rate is adjusted by that for daylight, one obtains 4% (95% CI −12% to +23%).

Conclusion No evidence was found for bright lamps leading to an improvement in road safety in any of the analyses. For this city, introducing brighter road lighting may have compromised safety rather than reducing harm.
 
  Address Room 221, Leighton Hall, Leeds Beckett University, Headingley Campus, Leeds LS1 3HE, UK; p.marchant(at) leedsbeckett.ac.uk  
  Corporate Author Thesis  
  Publisher BML Place of Publication Editor  
  Language English Summary Language English Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number IDA @ john @ Serial 2835  
Permanent link to this record
 

 
Author Fasciani, I.; Petragnano, F.; Aloisi, G.; Marampon, F.; Rossi, M.; Francesca Coppolino, M.; Rossi, R.; Longoni, B.; Scarselli, M.; Maggio, R. url  doi
openurl 
  Title A new threat to dopamine neurons: the downside of artificial light Type Journal Article
  Year 2020 Publication Neuroscience Abbreviated Journal Neuroscience  
  Volume in press Issue Pages (up) in press  
  Keywords Review; Human Health; Parkinson's disease; artificial light; dopamine neurons; melatonin; opsins; photoactivation  
  Abstract Growing awareness of adverse impacts of artificial light on human health has led to recognize light pollution as a significant global environmental issue. Despite, a large number of studies in rodent and monkey models of Parkinson's disease have reported that near infrared light has neuroprotective effects on dopaminergic neurons, recent findings have shown that prolonged exposure of rodents and birds to fluorescent artificial light results in an increase of neuromelanin granules in substantia nigra and loss of dopaminergic neurons. The observed detrimental effect seems to be dependent on a direct effect of light on the substantia nigra rather than a secondary effect of the alterations of circadian rhythms. Moreover, inferences from animal models to human studies have shown a positive correlation between the prevalence of Parkinson's disease and light pollution. The present article discusses experimental evidence supporting a potentially deleterious impact of light on dopaminergic neurons and highlights the mechanisms whereby light might damage neuronal tissue. Moreover, it analyses epidemiological evidence that suggests light pollution to be an environmental risk factor for Parkinson's disease.  
  Address Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy. Electronic address: roberto.maggio@univaq.it  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0306-4522 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:32142863 Approved no  
  Call Number GFZ @ kyba @ Serial 2839  
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