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Author Tosini, G.; Ferguson, I.; Tubota, K. url  openurl
  Title Effects of blue light on the circadian system and eye physiology Type Journal Article
  Year 2016 Publication Molecular Vision Abbreviated Journal Mol Vis  
  Volume 22 Issue Pages 61-72  
  Keywords (down) Vision; blue light; Circadian Rhythm; eye; physiology  
  Abstract Light-emitting diodes (LEDs) have been used to provide illumination in industrial and commercial environments. LEDs are also used in TVs, computers, smart phones, and tablets. Although the light emitted by most LEDs appears white, LEDs have peak emission in the blue light range (400–490 nm). The accumulating experimental evidence has indicated that exposure to blue light can affect many physiologic functions, and it can be used to treat circadian and sleep dysfunctions. However, blue light can also induce photoreceptor damage. Thus, it is important to consider the spectral output of LED-based light sources to minimize the danger that may be associated with blue light exposure. In this review, we summarize the current knowledge of the effects of blue light on the regulation of physiologic functions and the possible effects of blue light exposure on ocular health.  
  Address Department of Pharmacology and Toxicology and Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA  
  Corporate Author Thesis  
  Publisher NCBI Place of Publication Editor  
  Language English Summary Language English Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1090-0535 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number IDA @ john @ Serial 2216  
Permanent link to this record
 

 
Author Berman, S. url  doi
openurl 
  Title Opinion: Whither V(λ)? Type Journal Article
  Year 2019 Publication Lighting Research & Technology Abbreviated Journal Lighting Research & Technology  
  Volume 51 Issue 1 Pages 4-4  
  Keywords (down) Vision  
  Abstract  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1477-1535 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number GFZ @ kyba @ Serial 2219  
Permanent link to this record
 

 
Author Alaimo, A.; Linares, G.G.; Bujjamer, J.M.; Gorojod, R.M.; Alcon, S.P.; Martinez, J.H.; Baldessari, A.; Grecco, H.E.; Kotler, M.L. url  doi
openurl 
  Title Toxicity of blue led light and A2E is associated to mitochondrial dynamics impairment in ARPE-19 cells: implications for age-related macular degeneration Type Journal Article
  Year 2019 Publication Archives of Toxicology Abbreviated Journal Arch Toxicol  
  Volume in press Issue Pages  
  Keywords (down) Vision  
  Abstract Age-related macular degeneration (AMD) is a multifactorial retinal disease characterized by a progressive loss of central vision. Retinal pigment epithelium (RPE) degeneration is a critical event in AMD. It has been associated to A2E accumulation, which sensitizes RPE to blue light photodamage. Mitochondrial quality control mechanisms have evolved to ensure mitochondrial integrity and preserve cellular homeostasis. Particularly, mitochondrial dynamics involve the regulation of mitochondrial fission and fusion to preserve a healthy mitochondrial network. The present study aims to clarify the cellular and molecular mechanisms underlying photodamage-induced RPE cell death with particular focus on the involvement of defective mitochondrial dynamics. Light-emitting diodes irradiation (445 +/- 18 nm; 4.43 mW/cm(2)) significantly reduced the viability of both unloaded and A2E-loaded human ARPE-19 cells and increased reactive oxygen species production. A2E along with blue light, triggered apoptosis measured by MC540/PI-flow cytometry and activated caspase-3. Blue light induced mitochondrial fusion/fission imbalance towards mitochondrial fragmentation in both non-loaded and A2E-loaded cells which correlated with the deregulation of mitochondria-shaping proteins level (OPA1, DRP1 and OMA1). To our knowledge, this is the first work reporting that photodamage causes mitochondrial dynamics deregulation in RPE cells. This process could possibly contribute to AMD pathology. Our findings suggest that the regulation of mitochondrial dynamics may be a valuable strategy for treating retinal degeneration diseases, such as AMD.  
  Address Departamento de Quimica Biologica, Facultad de Ciencias Exactas y Naturales, Instituto de Quimica Biologica Ciencias Exactas y Naturales (IQUIBICEN), CONICET-Universidad de Buenos Aires, Pabellon 2, Ciudad Universitaria, 1428, Buenos Aires, Argentina. kotler@qb.fcen.uba.ar  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0340-5761 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:30778631 Approved no  
  Call Number GFZ @ kyba @ Serial 2229  
Permanent link to this record
 

 
Author Barrette, T.P.; Pike, A.M. url  doi
openurl 
  Title Closed-Course Human Factors Evaluation of Marking and Marker Visibility Type Journal Article
  Year 2019 Publication Transportation Research Record: Journal of the Transportation Research Board Abbreviated Journal Transportation Research Record  
  Volume in press Issue Pages  
  Keywords (down) Vision  
  Abstract Raised retroreflective pavement markers (RRPMs) are commonly used to provide nighttime delineation of roadways. Although RRPMs are visible during dry conditions, they provide their greatest benefit during wet-night conditions, when typical pavement markings become flooded and lose their retroreflectivite properties. Naturally, the retroreflectivity of RRPMs degrades over time as a result of traffic, ultraviolet light, precipitation, and roadway maintenance activities. Subsequently, it is necessary to examine the relationship between driver performance and the condition of the RRPMs. To assess visibility relative to RRPM condition, study participants rode in the passenger seat of a vehicle operated by a member of the research team, traveling at approximately 15 mph, for two laps around a closed course. Throughout each lap of the course, nine treatments consisting of RRPMs or preformed pavement marking tape of various retroreflectivity levels diverged from a center line to either the right or left. Participants indicated when they could tell which direction the treatment diverged, which was recorded using a GPS unit. A generalized linear model was estimated on a dataset constructed by pairing the observed distances from various treatments with demographic information about each participant. The analysis indicates the distance at which a particular treatment would be visible, which can then be converted to preview time to assess treatment adequacy for a variety of speeds. The RRPM treatments generally provided adequate preview time for older drivers based on the extant literature; however, the preformed pavement marking tape was less adequate at higher speeds and under overhead lighting.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0361-1981 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number GFZ @ kyba @ Serial 2499  
Permanent link to this record
 

 
Author Davoudian, N.; Raynham, P.; Barrett, E. url  doi
openurl 
  Title Disability glare: A study in simulated road lighting conditions Type Journal Article
  Year 2014 Publication Lighting Research & Technology Abbreviated Journal Lighting Research & Technology  
  Volume 46 Issue 6 Pages 695-705  
  Keywords (down) Vision  
  Abstract Disability glare is associated with veiling luminance caused by light from bright sources being scattered within the eyes of observers, thereby reducing retinal luminance contrast. This study compares the reduction in observers’ performance in the presence of glare with veiling luminance in the eye, calculated using a non-subjective method. A total of 42 observers performed a target detection task in the presence of a glare source in conditions similar to street lighting at night. Luminance contrast thresholds were measured for each observer under different levels of glare. Results show that, while veiling luminance has a significant effect on the performance of observers, its effect is lower than expected from contrast loss. Furthermore, the performance of observers over the age of 50 is unaffected by increasing the glare level.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1477-1535 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number GFZ @ kyba @ Serial 2526  
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