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Author Ma, Q.; Tan, Y.; Chen, X.; Chen, S.; Sun, Y.; Zhou, B.
Title Regulation of the MAPK signaling pathway by miR-421-5p in rats under light pollution Type Journal Article
Year 2018 Publication International Journal of Molecular Medicine Abbreviated Journal Int J Mol Med
Volume in press Issue Pages in press
Keywords (up) Animals
Abstract The present study aimed to explore the difference in the expression profiles of ovarian microRNA sequences in rats in a light pollution environment and rats in a normal light environment. Rats in the control group were exposed to 12h light/dark cycles, while rats in the model group were continuously exposed to 24h light. The ovaries were extracted from the two groups of rats, and Illumina HiSeq 2500 highthroughput sequencing technology was used to detect the differences in microRNA (miRNA) expression among the two groups. Fluorescence quantitative reverse transcriptionpolymerase chain reaction was used to verify the differential expression of miRNA. The present study was designed to experimentally validate the interaction between miR4215p and mitogenactivated protein kinase (MAPK) 7 by using the dualluciferase reporter system, and to explore the expression of proteins in the MAPK signaling pathway with a lentiviral vectormediated small hairpin RNA interference against microRNA4215p. The expression of 45 miRNAs was significantly different. In total, 13 miRNAs were upregulated, of which 5 miRNA sequences were known and 8 were predicted. Furthermore, 32 miRNAs were downregulated, of which 11 miRNA sequences were known and 21 were predicted. The results of the luciferase reporter assay confirmed the targeting association between miR4215p and MAPK7. The expression levels of MAPK and genes in its downstream signaling pathways, including cFos, CREB and cMyc, were downregulated when miR4215p was overexpressed and upregulated when miR4215p was silenced. The differential expression of miRNAs may serve an important role in the development of the ovary in a light pollution environment. miR4215p may regulate ovarian growth and development by targeting the MAPK signaling pathway in light polluted rat ovaries.
Address Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, P.R. China
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1107-3756 ISBN Medium
Area Expedition Conference
Notes PMID:30221682 Approved no
Call Number GFZ @ kyba @ Serial 2005
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Author Raap, T.; Thys, B.; Grunst, A.S.; Grunst, M.L.; Pinxten, R.; Eens, M.
Title Personality and artificial light at night in a semi-urban songbird population: No evidence for personality-dependent sampling bias, avoidance or disruptive effects on sleep behaviour Type Journal Article
Year 2018 Publication Environmental Pollution Abbreviated Journal Environmental Pollution
Volume in press Issue Pages in press
Keywords (up) Animals
Abstract Light pollution or artificial light at night (ALAN) is an increasing, worldwide challenge that affects many aspects of animal behaviour. Interestingly, the response to ALAN varies widely among individuals within a population and variation in personality (consistent individual differences in behaviour) may be an important factor explaining this variation. Consistent individual differences in exploration behaviour in particular may relate to the response to ALAN, as increasing evidence indicates its relation with how individuals respond to novelty and how they cope with anthropogenic modifications of the environment. Here, we assayed exploration behaviour in a novel environment as a proxy for personality variation in great tits (Parus major). We observed individual sleep behaviour over two consecutive nights, with birds sleeping under natural dark conditions the first night and confronted with ALAN inside the nest box on the second night, representing a modified and novel roosting environment. We examined whether roosting decisions when confronted with a camera (novel object), and subsequently with ALAN, were personality-dependent, as this could potentially create sampling bias. Finally, we assessed whether experimentally challenging individuals with ALAN induced personality-dependent changes in sleep behaviour.

Slow and fast explorers were equally likely to roost in a nest box when confronted with either a camera or artificial light inside, indicating the absence of personality-dependent sampling bias or avoidance of exposure to ALAN. Moreover, slow and fast explorers were equally disrupted in their sleep behaviour when challenged with ALAN. Whether other behavioural and physiological effects of ALAN are personality-dependent remains to be determined. Moreover, the sensitivity to disturbance of different behavioural types might depend on the behavioural context and the specific type of challenge in question. In our increasingly urbanized world, determining whether the effects of anthropogenic stressors depend on personality type will be of paramount importance as it may affect population dynamics.
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0269-7491 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number GFZ @ kyba @ Serial 2008
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Author Taufique, S.K.T.; Prabhat, A.; Kumar, V.
Title Illuminated night alters hippocampal gene expressions and induces depressive-like responses in diurnal corvids Type Journal Article
Year 2018 Publication The European Journal of Neuroscience Abbreviated Journal Eur J Neurosci
Volume in press Issue Pages in press
Keywords (up) Animals
Abstract Artificial light at night induces circadian disruptions and causes cognitive impairment and mood disorders; yet very little is known about the neural and molecular correlates of these effects in diurnal animals. We manipulated the night environment and examined cellular and molecular changes in hippocampus, the brain region involved in cognition and mood, of Indian house crows (Corvus splendens) exposed to 12 h light (150 lux): 12 h darkness (0 lux). Diurnal corvids are an ideal model species with cognitive abilities at par with mammals. Dim light (6 lux) at night (dLAN) altered daily activity:rest pattern, reduced sleep and induced depressive-like responses (decreased eating and self-grooming, self-mutilation and reduced novel object exploration); return to an absolute dark night reversed these negative effects. dLAN suppressed nocturnal melatonin levels, however, diurnal corticosterone levels were unaffected. Concomitant reduction of immunoreactivity for DCX and BDNF suggested dLAN-induced suppression of hippocampal neurogenesis and compromised neuronal health. dLAN also negatively influenced hippocampal expression of genes associated with depressive-like responses (bdnf, il-1beta, tnfr1, nr4a2), but not of those associated with neuronal plasticity (egr1, creb, syngap, syn2, grin2a, grin2b), cellular oxidative stress (gst, sod3, cat1) and neuronal death (caspase2, caspase3, foxo3). Furthermore, we envisaged the role of BDNF and showed epigenetic modification of bdnf gene by decreased histone H3 acetylation and increased hdac4 expression under dLAN. These results demonstrate transcriptional and epigenetic bases of dLAN-induced negative effects in diurnal crows, and provide insights into the risks of exposure to illuminated nights to animals including humans in an urban setting. This article is protected by copyright. All rights reserved.
Address IndoUS Center for Biological Timing Department of Zoology, University of Delhi, Delhi, 110 007, India
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0953-816X ISBN Medium
Area Expedition Conference
Notes PMID:30218624 Approved no
Call Number GFZ @ kyba @ Serial 2010
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Author Kurvers, R.H.J.M.; Drägestein, J.; Hölker, F.; Jechow, A.; Krause, J.; Bierbach, D.
Title Artificial Light at Night Affects Emergence from a Refuge and Space Use in Guppies Type Journal Article
Year 2018 Publication Scientific Reports Abbreviated Journal Sci Rep
Volume 8 Issue 1 Pages
Keywords (up) Animals
Abstract Artificial light at night (ALAN) is a major form of anthropogenic pollution. ALAN is well known to affect different behaviours during nighttime, when changes in light conditions often have immediate consequences for the trade-offs individuals experience. How ALAN affects daytime behaviours, however, has received far less attention. Here we studied how ALAN affected daytime personality traits and learning ability. We exposed Trinidadian guppies, Poecilia reticulata, for 10 weeks to different ALAN levels: bright light (24 hrs bright light, ~5,000 lx), dim light (12 hrs bright light; 12 hrs dim light, ~0.5 lx) and control (12 hrs bright light; 12 hrs dark). Afterwards, we tested how the treatments affected diurnal emergence from a refuge, space use, activity, sociability and the ability to memorize the location of companion fish. Individuals exposed to the light treatments (both dim and bright light) emerged quicker from a refuge and fish from the bright light treatment spent relatively more time in the open area of the arena. ALAN did not affect any of the other behaviours, although memory could not be tested since fish did not learn the companions’ location. Our results demonstrate that ALAN, next to affecting nocturnal behaviours, can also affect key diurnal behavioural processes, associated with risk-taking.
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 2045-2322 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number GFZ @ kyba @ Serial 2013
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Author Kumlien, L.
Title Observations on Bird Migration at Milwaukee Type Journal Article
Year 1888 Publication The Auk Abbreviated Journal The Auk
Volume 5 Issue 3 Pages 325-328
Keywords (up) Animals
Abstract
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0004-8038 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number GFZ @ kyba @ Serial 2019
Permanent link to this record