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Author Bumgarner, J.R.; Walker, W.H. 2nd; Liu, J.A.; Walton, J.C.; Nelson, R.J. url  doi
openurl 
  Title Dim light at night exposure induces cold hyperalgesia and mechanical allodynia in male mice Type Journal Article
  Year 2020 Publication Neuroscience Abbreviated Journal Neuroscience  
  Volume in press Issue Pages  
  Keywords (up) Animals; Allodynia; Hyperalgesia; Light at Night; Neuroinflammation; Opioid; Pain  
  Abstract The growing presence of artificial lighting across the globe presents a number of challenges to human and ecological health despite its societal benefits. Exposure to artificial light at night, a seemingly innocuous aspect of modern life, disrupts behavior and physiological functions. Specifically, light at night induces neuroinflammation, which is implicated in neuropathic and nociceptive pain states, including hyperalgesia and allodynia. Because of its influence on neuroinflammation, we investigated the effects of dim light at night exposure on pain responsiveness in male mice. In this study, mice exposed to four days of dim (5 lux) light at night exhibited cold hyperalgesia. Further, after 28 days of exposure, mice exhibited both cold hyperalgesia and mechanical allodynia. No heat/hot hyperalgesia was observed in this experiment. Altered nociception in mice exposed to dim light at night was concurrent with upregulated interleukin-6 and nerve growth factor mRNA expression in the medulla and elevated mu-opioid receptor mRNA expression in the periaqueductal gray region of the brain. The current results support the relationship between disrupted circadian rhythms and altered pain sensitivity. In summary, we observed that dim light at night induces cold hyperalgesia and mechanical allodynia, potentially through elevated central neuroinflammation and dysregulation of the endogenous opioid system.  
  Address Department of Neuroscience, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, 26506 United States  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0306-4522 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:32201267 Approved no  
  Call Number GFZ @ kyba @ Serial 2864  
Permanent link to this record
 

 
Author Gaston, M.S.; Pereyra, L.C.; Vaira, M. url  doi
openurl 
  Title Artificial light at night and captivity induces differential effects on leukocyte profile, body condition, and erythrocyte size of a diurnal toad Type Journal Article
  Year 2018 Publication Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology Abbreviated Journal J Exp Zool A Ecol Integr Physiol  
  Volume in press Issue Pages  
  Keywords (up) Animals; Amphibians; Toads  
  Abstract Light pollution or artificial lighting at night (ALAN) is an emerging threat to biodiversity that can disrupt physiological processes and behaviors. Because ALAN stressful effects are little studied in diurnal amphibian species, we investigated if chronic ALAN exposure affects the leukocyte profile, body condition, and blood cell sizes of a diurnal toad. We hand-captured male toads of Melanophryniscus rubriventris in Angosto de Jaire (Jujuy, Argentina). We prepared blood smears from three groups of toads: “field” (toads processed in the field immediately after capture), “natural light” (toads kept in the laboratory under captivity with natural photoperiod), and “constant light” (toads kept in the laboratory under captivity with constant photoperiod/ALAN). We significantly observed higher neutrophil proportions and neutrophils to lymphocytes ratio in toads under constant light treatment. In addition, we observed significantly better body condition and higher erythrocyte size in field toads compared with captive toads. In summary, ALAN can trigger a leukocyte response to stress in males of the diurnal toad M. rubriventris. In addition, captivity can affect the body condition and erythrocyte size of these toads.  
  Address Instituto de Ecorregiones Andinas (INECOA), Universidad Nacional de Jujuy, CONICET, San Salvador de Jujuy, Argentina  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 2471-5638 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:30320969 Approved no  
  Call Number GFZ @ kyba @ Serial 2049  
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Author Sharma, A.; Goyal, R. url  doi
openurl 
  Title Long-term exposure to constant light induces dementia, oxidative stress and promotes aggregation of sub-pathological Abeta42 in Wistar rats Type Journal Article
  Year 2020 Publication Pharmacology, Biochemistry, and Behavior Abbreviated Journal Pharmacol Biochem Behav  
  Volume in press Issue Pages 172892  
  Keywords (up) Animals; Amyloid beta; Behavior, fluoxetine, rifampicin; Oxidative stress  
  Abstract Constant exposure to light is prevalent in modern society where light noise, shift work, and jet lag is common. Constant light exposure disrupts circadian rhythm, induces stress and thus influences memory performance. We subjected adult male Wistar rats to a two-month exposure to constant light (LL), constant dark or normal light-dark cycles. Significant cognitive impairment and oxidative stress were observed in LL rats without a significant elevation in soluble Abeta1-42 levels. Next, we examined whether long-term exposure to constant light may accelerate dementia in a sub-pathological Abeta model of rats. Normal control rats received ACSF, AD rats received 440pmol, and sub-pathological Abeta rats (Abeta(s)) received 220pmol of human Abeta42 peptide in a single unilateral ICV administration. Sub-pathological Abeta rats exposed to constant light (LL+Abeta(s)) show significant memory deficits and oxidative damage, although not significantly different from LL rats. Additionally, constant light promoted aggregation of exogenous Abeta42 in LL+Abeta(s) rats shown by the presence of congophilic plaques. Furthermore, chronic fluoxetine treatment (5mg/kg/day) rescued rats from the behavioral deficits, oxidative damage and amyloid aggregation. Whereas, rifampicin treatment (20mg/kg/day) did not reverse the behavioral deficits or oxidative stress but rescued rats from amyloid plaque formation. It was concluded that constant light for two months induces behavioral deficits, oxidative stress, and accelerates aggregation of sub-pathological concentrations of human-Abeta42 peptides in Wistar rats, which is reversed by daily fluoxetine administration.  
  Address Neuropharmacology Laboratory, School of Pharmaceutical Sciences, Shoolini University, Solan 173 212, Himachal Pradesh, India. Electronic address: rohitgoyal@shooliniuniversity.com  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0091-3057 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:32142744 Approved no  
  Call Number GFZ @ kyba @ Serial 2841  
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Author Hoffmann, J.; Schirmer, A.; Eccard, J.A. url  doi
openurl 
  Title Light pollution affects space use and interaction of two small mammal species irrespective of personality Type Journal Article
  Year 2019 Publication BMC Ecology Abbreviated Journal BMC Ecol  
  Volume 19 Issue 1 Pages 26  
  Keywords (up) Animals; Animal personality; Hirec; Interspecific interactions; Nighttime illumination; Outdoor enclosure; Rodents  
  Abstract BACKGROUND: Artificial light at night (ALAN) is one form of human-induced rapid environmental changes (HIREC) and is strongly interfering with natural dark-light cycles. Some personality types within a species might be better suited to cope with environmental change and therefore might be selected upon under ongoing urbanization. RESULTS: We used LED street lamps in a large outdoor enclosure to experimentally investigate the effects of ALAN on activity patterns, movement and interaction of individuals of two species, the bank vole (Myodes glareolus) and the striped field mouse (Apodemus agrarius). We analyzed effects combined with individual boldness score. Both species reduced their activity budget during daylight hours. While under natural light conditions home ranges were larger during daylight than during nighttime, this difference vanished under ALAN. Conspecifics showed reduced home range overlap, proximity and activity synchrony when subjected to nighttime illumination. Changes in movement patterns in reaction to ALAN were not associated with differences in boldness score of individuals. CONCLUSIONS: Our results suggest that light pollution can lead to changes in movement patterns and individual interactions in small mammals. This could lead to fitness consequences on the population level.  
  Address Animal Ecology, University of Potsdam, Maulbeerallee 1, 14469, Potsdam, Germany  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1472-6785 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:31215409; PMCID:PMC6582560 Approved no  
  Call Number GFZ @ kyba @ Serial 2584  
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Author Yue, F.; Xia, K.; Wei, L.; Xing, L.; Wu, S.; Shi, Y.; Man, L.S.; Shui, G.; Xiang, X.; Russell, R.; Zhang, D. url  doi
openurl 
  Title Constant light exposure causes dysregulation of sphingolipids and promotes steatohepatitis in high-fat fed rats Type Journal Article
  Year 2020 Publication Journal of Gastroenterology and Hepatology Abbreviated Journal J Gastroenterol Hepatol  
  Volume in press Issue Pages  
  Keywords (up) Animals; apoptosis; ceramide; light pollution; non-alcoholic fatty liver disease; sphingolipids  
  Abstract BACKGROUND AND AIM: Non-alcoholic fatty liver disease (NAFLD) is a growing public health concern worldwide. With the progression of urbanization, light pollution is becoming an inevitable risk factor for NAFLD. However, the role of light pollution on NAFLD is insufficiently understood, and the underlying mechanism remains unclear. The present study explored effects of constant light exposure on NAFLD and elucidated its related mechanisms. METHODS: Thirty-two male SD rats were divided into 4 groups (n=8 each): 1) rats on a normal diet exposed to standard light-dark cycle (ND-LD); 2) rats on a normal diet exposed to constant light (ND-LL); 3) rats on a high fat diet exposed to standard light-dark cycle (HFD-LD); 4) and rats on a high fat diet exposed to constant light (HFD-LL). After 12 weeks treatment, rats were sacrificed and pathophysiological assessments were performed. Targeted lipidomics was used to measure sphingolipids, including ceramides, glucosylceramides and lactosylceramides, sphingomyelins and sphingosine-1-phosphates in plasma and liver tissues. RESULTS: In normal chow rats, constant light exposure led to glucose abnormalities and dyslipidemia. In high-fat fed rats, constant light exposure exacerbated glucose abnormalities, dyslipidemia, insulin resistance, inflammation and aggravated steatohepatitis. Compared to HFD-LD rats, HFD-LL had decreased plasma sphingosine-1-phosphate and elevated liver concentrations of total ceramides and specific ceramide species (ceramide d18:0/24:0, ceramide d18:1/22:0, ceramide d18:1/24:0 and ceramide d18:1/24:1), and which were associated with increased hepatocyte apoptosis. CONCLUSIONS: Constant light exposure causes dysregulation of sphingolipids and promotes steatohepatitis in high-fat fed rats.  
  Address Department of Endocrinology, Xiangya Hospital, Central South University, Changsha, Hunan, China  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0815-9319 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:32027419 Approved no  
  Call Number GFZ @ kyba @ Serial 2829  
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