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Author Alaimo, A.; Linares, G.G.; Bujjamer, J.M.; Gorojod, R.M.; Alcon, S.P.; Martinez, J.H.; Baldessari, A.; Grecco, H.E.; Kotler, M.L.
Title Toxicity of blue led light and A2E is associated to mitochondrial dynamics impairment in ARPE-19 cells: implications for age-related macular degeneration Type Journal Article
Year 2019 Publication Archives of Toxicology Abbreviated Journal Arch Toxicol
Volume 93 Issue 5 Pages 1401-1415
Keywords Vision; age-related macular degeneration; Eye; Eye Diseases; blue light
Abstract Age-related macular degeneration (AMD) is a multifactorial retinal disease characterized by a progressive loss of central vision. Retinal pigment epithelium (RPE) degeneration is a critical event in AMD. It has been associated to A2E accumulation, which sensitizes RPE to blue light photodamage. Mitochondrial quality control mechanisms have evolved to ensure mitochondrial integrity and preserve cellular homeostasis. Particularly, mitochondrial dynamics involve the regulation of mitochondrial fission and fusion to preserve a healthy mitochondrial network. The present study aims to clarify the cellular and molecular mechanisms underlying photodamage-induced RPE cell death with particular focus on the involvement of defective mitochondrial dynamics. Light-emitting diodes irradiation (445 +/- 18 nm; 4.43 mW/cm(2)) significantly reduced the viability of both unloaded and A2E-loaded human ARPE-19 cells and increased reactive oxygen species production. A2E along with blue light, triggered apoptosis measured by MC540/PI-flow cytometry and activated caspase-3. Blue light induced mitochondrial fusion/fission imbalance towards mitochondrial fragmentation in both non-loaded and A2E-loaded cells which correlated with the deregulation of mitochondria-shaping proteins level (OPA1, DRP1 and OMA1). To our knowledge, this is the first work reporting that photodamage causes mitochondrial dynamics deregulation in RPE cells. This process could possibly contribute to AMD pathology. Our findings suggest that the regulation of mitochondrial dynamics may be a valuable strategy for treating retinal degeneration diseases, such as AMD.
Address Departamento de Quimica Biologica, Facultad de Ciencias Exactas y Naturales, Instituto de Quimica Biologica Ciencias Exactas y Naturales (IQUIBICEN), CONICET-Universidad de Buenos Aires, Pabellon 2, Ciudad Universitaria, 1428, Buenos Aires, Argentina. kotler@qb.fcen.uba.ar
Corporate Author Thesis
Publisher Place of Publication Editor
Language (down) English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0340-5761 ISBN Medium
Area Expedition Conference
Notes PMID:30778631 Approved no
Call Number GFZ @ kyba @ Serial 2229
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Author Youngstedt, S.D.; Elliott, J.A.; Kripke, D.F.
Title Human Circadian Phase-Response Curves for Exercise Type Journal Article
Year 2019 Publication The Journal of Physiology Abbreviated Journal J Physiol
Volume 597 Issue 8 Pages 2253-2268
Keywords Human Health; Circadian Rhythm; Exercise
Abstract KEY POINTS: Exercise elicits circadian phase-shifting effects, but additional information is needed. The phase-response curve describing the magnitude and direction of circadian rhythm phase shifts depending on the time of the zeigeber (time cue) stimulus is the most fundamental chronobiological tool for alleviating circadian misalignment and related morbidity. 51 older and 48 young adults followed a circadian rhythms measurement protocol for up to 5.5 days, and performed 1 h of moderate treadmill exercise for 3 consecutive days at one of 8 times of day/night. Temporal changes in the phase of 6-sulphatoxymelatonin (aMT6s) were measured from evening onset, cosine acrophase, morning offset, and duration of excretion, establishing significant PRCs for aMT6 onset and acrophase with large phase delays from 7-10 PM and large phase advances at both 7 AM and 1-4 PM. Along with known synergism with bright light, the above PRCs with a second phase advance region (afternoon) could support both practical and clinical applications. ABSTRACT: Although bright light is regarded as the primary circadian zeitgeber, its limitations support exploring alternative zeitgebers. Exercise elicits significant circadian phase-shifting effects, but fundamental information regarding these effects is needed. The primary aim of this study was to establish phase-response curves (PRC) documenting the size and direction of phase shifts in relation to the circadian time of exercise. Aerobically fit older (n = 51, 59-75 y) and young adults (n = 48, 18-30 y) followed a 90-min laboratory ultra-short sleep wake cycle (60 min wake/30 min sleep) for up to 5 (1/2) days. At the same clock time on three consecutive days, each participant performed 60 min of moderate treadmill exercise (65-75% of heart rate reserve) at one of 8 times of day/night. To describe PRCs, phase shifts were measured for the cosine-fitted acrophase of urinary 6-sulphatoxymelatonin (aMT6s), as well as for the evening rise, morning decline, and change in duration of aMT6s excretion. Significant PRCs were found for aMT6s acrophase, onset and duration, with peak phase advances corresponding to clock times of 7 AM and 1PM-4PM, delays from 7 PM-10 PM, and minimal shifts around 4 PM and 2 AM. There were no significant age or sex differences. The amplitudes of the aMT6s onset and acrophase PRCs are comparable to expectations for bright light of equal duration. The phase advance to afternoon exercise and the exercise-induced PRC for change in aMT6s duration are novel findings. The results support further research exploring additive phase shifting effects of bright light and exercise and health benefits. This article is protected by copyright. All rights reserved.
Address Department of Psychiatry, University of California, San Diego, CA
Corporate Author Thesis
Publisher Place of Publication Editor
Language (down) English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0022-3751 ISBN Medium
Area Expedition Conference
Notes PMID:30784068 Approved no
Call Number GFZ @ kyba @ Serial 2230
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Author Clayson, Hollis
Title Illuminated Paris, Essays on Art and Lighting in the Belle Époque Type Book Whole
Year 2019 Publication Abbreviated Journal
Volume Issue Pages
Keywords History; Society; Art
Abstract The City of Light. For many, these four words instantly conjure late nineteenth-century Paris and the garish colors of Toulouse-Lautrec’s iconic posters. More recently, the Eiffel Tower’s nightly show of sparkling electric lights has come to exemplify our fantasies of Parisian nightlife. Though we reflect longingly on such scenes, in Illuminated Paris, Hollis Clayson shows that there’s more to these clichés than meets the eye. In this richly illustrated book, she traces the dramatic evolution of lighting in Paris and how artists responded to the shifting visual and cultural scenes that resulted from these technologies. While older gas lighting produced a haze of orange, new electric lighting was hardly an improvement: the glare of experimental arc lights—themselves dangerous—left figures looking pale and ghoulish. As Clayson shows, artists’ representations of these new colors and shapes reveal turn-of-the-century concerns about modernization as electric lighting came to represent the harsh glare of rapidly accelerating social change. At the same time, in part thanks to American artists visiting the city, these works of art also produced our enduring romantic view of Parisian glamour and its Belle Époque.
Address Chicago
Corporate Author Thesis
Publisher University of Chicago Press Place of Publication Chicago Editor
Language (down) English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN 9780226593869 Medium
Area Expedition Conference
Notes Approved no
Call Number GFZ @ kyba @ Serial 2231
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Author Nelson, J.A.; Bugbee, B.
Title Economic analysis of greenhouse lighting: light emitting diodes vs. high intensity discharge fixtures Type Journal Article
Year 2014 Publication PloS one Abbreviated Journal PLoS One
Volume 9 Issue 6 Pages e99010
Keywords Plants
Abstract Lighting technologies for plant growth are improving rapidly, providing numerous options for supplemental lighting in greenhouses. Here we report the photosynthetic (400-700 nm) photon efficiency and photon distribution pattern of two double-ended HPS fixtures, five mogul-base HPS fixtures, ten LED fixtures, three ceramic metal halide fixtures, and two fluorescent fixtures. The two most efficient LED and the two most efficient double-ended HPS fixtures had nearly identical efficiencies at 1.66 to 1.70 micromoles per joule. These four fixtures represent a dramatic improvement over the 1.02 micromoles per joule efficiency of the mogul-base HPS fixtures that are in common use. The best ceramic metal halide and fluorescent fixtures had efficiencies of 1.46 and 0.95 micromoles per joule, respectively. We also calculated the initial capital cost of fixtures per photon delivered and determined that LED fixtures cost five to ten times more than HPS fixtures. The five-year electric plus fixture cost per mole of photons is thus 2.3 times higher for LED fixtures, due to high capital costs. Compared to electric costs, our analysis indicates that the long-term maintenance costs are small for both technologies. If widely spaced benches are a necessary part of a production system, the unique ability of LED fixtures to efficiently focus photons on specific areas can be used to improve the photon capture by plant canopies. Our analysis demonstrates, however, that the cost per photon delivered is higher in these systems, regardless of fixture category. The lowest lighting system costs are realized when an efficient fixture is coupled with effective canopy photon capture.
Address Crop Physiology Laboratory, Department of Plant Soils and Climate, Utah State University, Logan, Utah, United States of America
Corporate Author Thesis
Publisher Place of Publication Editor
Language (down) English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1932-6203 ISBN Medium
Area Expedition Conference
Notes PMID:24905835; PMCID:PMC4048233 Approved no
Call Number GFZ @ kyba @ Serial 2233
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Author Pagden, M.; Ngahane, K.; Amin, M.S.R.
Title Changing the colour of night on urban streets – LED vs. part-night lighting system Type Journal Article
Year 2019 Publication Socio-Economic Planning Sciences Abbreviated Journal Socio-Economic Planning Sciences
Volume in press Issue Pages 100692
Keywords Energy; Planning; Economics; United Kingdom; LED; Lighting
Abstract Many cities in the United Kingdom are upgrading the streetlights to white light-emitting diode (LED) lamps for reducing the electricity costs and attaining the sustainable energy solutions. Installation of LED lamps on urban street requires higher installation costs and a long-term period to payback benefits of replacing outdated streetlights in terms of energy savings and costs. To achieve the short-term energy efficiency of urban street lighting, city councils sometimes adopt the part-night lighting system particularly in the residential areas. The Coventry City Council recently replaced 29,701 existing sodium lights with LED lamps. This paper performs the economic analyses to understand the feasibility of two street lighting systems: LED lamps and ‘part-night’ lightings on the Coventry streets during the twenty-year period assuming the return period of investment is twenty years. The projection of energy consumption and costs for LED lamps and part-night lighting systems shows that electricity can be saved by 44% and 21% comparing to current electricity usages, respectively. Considering the budgetary constraints of Coventry City Council, this paper concludes that the part-night lighting system may be beneficial in short-term period, but it is economically feasible to replace the existing lower efficiency lights with LED lamps.
Address Faculty of Engineering, Environment & Computing, Coventry University, Priory St, Coventry, West Midlands, CV1 5FB, United Kingdom; pagdenm(at)uni.coventry.ac.uk
Corporate Author Thesis
Publisher English Place of Publication Editor
Language (down) English Summary Language English Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0038-0121 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number GFZ @ kyba @ Serial 2234
Permanent link to this record