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Author Zubidat, A.E.; Fares, B.; Fares, F.; Haim, A. url  doi
openurl 
  Title Artificial Light at Night of Different Spectral Compositions Differentially Affects Tumor Growth in Mice: Interaction With Melatonin and Epigenetic Pathways Type Journal Article
  Year 2018 Publication (up) Cancer Control : Journal of the Moffitt Cancer Center Abbreviated Journal Cancer Control  
  Volume 25 Issue 1 Pages 1073274818812908  
  Keywords Human Health; 6-Smt; Cfl; EE-halogen; GDM-levels; body mass; carbon; corticosterone; cosinor analysis; light at night; yellow-LED  
  Abstract Lighting technology is rapidly advancing toward shorter wavelength illuminations that offer energy-efficient properties. Along with this advantage, the increased use of such illuminations also poses some health challenges, particularly breast cancer progression. Here, we evaluated the effects of artificial light at night (ALAN) of 4 different spectral compositions (500-595 nm) at 350 Lux on melatonin suppression by measuring its urine metabolite 6-sulfatoxymelatonin, global DNA methylation, tumor growth, metastases formation, and urinary corticosterone levels in 4T1 breast cancer cell-inoculated female BALB/c mice. The results revealed an inverse dose-dependent relationship between wavelength and melatonin suppression. Short wavelength increased tumor growth, promoted lung metastases formation, and advanced DNA hypomethylation, while long wavelength lessened these effects. Melatonin treatment counteracted these effects and resulted in reduced cancer burden. The wavelength suppression threshold for melatonin-induced tumor growth was 500 nm. These results suggest that short wavelength increases cancer burden by inducing aberrant DNA methylation mediated by the suppression of melatonin. Additionally, melatonin suppression and global DNA methylation are suggested as promising biomarkers for early diagnosis and therapy of breast cancer. Finally, ALAN may manifest other physiological responses such as stress responses that may challenge the survival fitness of the animal under natural environments.  
  Address 1 The Israeli Center for Interdisciplinary Research in Chronobiology, University of Haifa, Haifa, Israel  
  Corporate Author Thesis  
  Publisher SAGE Place of Publication Editor  
  Language English Summary Language English Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1073-2748 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:30477310; PMCID:PMC6259078 Approved no  
  Call Number IDA @ john @ Serial 2143  
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Author Leung, L.; Grundy, A.; Siemiatycki, J.; Arseneau, J.; Gilbert, L.; Gotlieb, W.H.; Provencher, D.M.; Aronson, K.J.; Koushik, A. url  doi
openurl 
  Title Shift Work Patterns, Chronotype, and Epithelial Ovarian Cancer Risk Type Journal Article
  Year 2019 Publication (up) Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology Abbreviated Journal Cancer Epidemiol Biomarkers Prev  
  Volume in press Issue Pages 1055-9965.EPI-18-1112  
  Keywords Human Health; chronotype; Cancer; epithelial ovarian cancer; Ovarian cancer  
  Abstract BACKGROUND: Shift work causing circadian disruption is classified as a 'probable carcinogen' and may contribute to the pathogenesis of hormone-sensitive cancers. This study investigated shift work exposure in relation to epithelial ovarian cancer (EOC) risk. METHODS: In a population-based case-control study with 496 EOC cases and 906 controls, lifetime occupational histories were collected and used to calculate cumulative years of shift work exposure, average number of night shifts per month, and average number of consecutive night shifts per month. Odds ratios (ORs) and 95% confidence intervals (CIs) for associations with EOC risk were estimated using logistic regression. Associations were also examined according to chronotype and menopausal status. RESULTS: Over half of the cases (53.4%) and controls (51.7%) worked evening and/or night shifts. There was no clear pattern of increasing EOC risk with increasing years of shift work; the adjusted OR (95%CI) of EOC comparing the highest shift work category vs. never working shift work was 1.20 (0.89-1.63). This association was more pronounced among those self-identified as having a “morning” chronotype (OR=1.64, 95%CI: 1.01-2.65). Associations did not greatly differ by menopausal status. CONCLUSION: These results do not strongly demonstrate a relationship between shift work and EOC risk. IMPACT: This study collected detailed shift work information and examined shift work patterns according to shift times and schedules. The findings highlight that chronotype should be considered in studies of shift work as an exposure.  
  Address Department of Social and Preventive Medicine, Universite de Montreal; Department of Social and Preventive Medicine  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1055-9965 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:30842128 Approved no  
  Call Number GFZ @ kyba @ Serial 2261  
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Author Chen, J.; Zhao, F.; Zeng, N.; Oda, T. url  doi
openurl 
  Title Comparing a global high-resolution downscaled fossil fuel CO2 emission dataset to local inventory-based estimates over 14 global cities Type Journal Article
  Year 2020 Publication (up) Carbon Balance and Management Abbreviated Journal Carbon Balance Manag  
  Volume 15 Issue 1 Pages 9  
  Keywords Remote Sensing; City CO2 emissions; Emission inventory; Fossil fuel CO2 emissions; In-boundary; Odiac  
  Abstract BACKGROUND: Compilation of emission inventories (EIs) for cities is a whole new challenge to assess the subnational climate mitigation effort under the Paris Climate Agreement. Some cities have started compiling EIs, often following a global community protocol. However, EIs are often difficult to systematically examine because of the ways they were compiled (data collection and emission calculation) and reported (sector definition and direct vs consumption). In addition, such EI estimates are not readily applicable to objective evaluation using modeling and observations due to the lack of spatial emission extents. City emission estimates used in the science community are often based on downscaled gridded EIs, while the accuracy of the downscaled emissions at city level is not fully assessed. RESULTS: This study attempts to assess the utility of the downscaled emissions at city level. We collected EIs from 14 major global cities and compare them to the estimates from a global high-resolution fossil fuel CO2 emission data product (ODIAC) commonly used in the science research community. We made necessary adjustments to the estimates to make our comparison as reasonable as possible. We found that the two methods produce very close area-wide emission estimates for Shanghai and Delhi (< 10% difference), and reach good consistency in half of the cities examined (< 30% difference). The ODIAC dataset exhibits a much higher emission compared to inventory estimates in Cape Town (+ 148%), Sao Paulo (+ 43%) and Beijing (+ 40%), possibly related to poor correlation between nightlight intensity with human activity, such as the high-emission and low-lighting industrial parks in developing countries. On the other hand, ODIAC shows lower estimates in Manhattan (- 62%), New York City (- 45%), Washington D.C. (- 42%) and Toronto (- 33%), all located in North America, which may be attributable to an underestimation of residential emissions from heating in ODIAC's nightlight-based approach, and an overestimation of emission from ground transportation in registered vehicles statistics of inventory estimates. CONCLUSIONS: The relatively good agreement suggests that the ODIAC data product could potentially be used as a first source for prior estimate of city-level CO2 emission, which is valuable for atmosphere CO2 inversion modeling and comparing with satellite CO2 observations. Our compilation of in-boundary emission estimates for 14 cities contributes towards establishing an accurate inventory in-boundary global city carbon emission dataset, necessary for accountable local climate mitigation policies in the future.  
  Address Goddard Earth Sciences Research and Technology, Universities Space Research Association, Columbia, MD, USA  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1750-0680 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:32430547 Approved no  
  Call Number GFZ @ kyba @ Serial 2929  
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Author Welz, P.-S.; Zinna, V.M.; Symeonidi, A.; Koronowski, K.B.; Kinouchi, K.; Smith, J.G.; Guillen, I.M.; Castellanos, A.; Crainiciuc, G.; Prats, N.; Caballero, J.M.; Hidalgo, A.; Sassone-Corsi, P.; Benitah, S.A. url  doi
openurl 
  Title BMAL1-Driven Tissue Clocks Respond Independently to Light to Maintain Homeostasis Type Journal Article
  Year 2019 Publication (up) Cell Abbreviated Journal Cell  
  Volume 177 Issue 6 Pages 1436-1447.e12  
  Keywords Animals  
  Abstract Circadian rhythms control organismal physiology throughout the day. At the cellular level, clock regulation is established by a self-sustained Bmal1-dependent transcriptional oscillator network. However, it is still unclear how different tissues achieve a synchronized rhythmic physiology. That is, do they respond independently to environmental signals, or require interactions with each other to do so? We show that unexpectedly, light synchronizes the Bmal1-dependent circadian machinery in single tissues in the absence of Bmal1 in all other tissues. Strikingly, light-driven tissue autonomous clocks occur without rhythmic feeding behavior and are lost in constant darkness. Importantly, tissue-autonomous Bmal1 partially sustains homeostasis in otherwise arrhythmic and prematurely aging animals. Our results therefore support a two-branched model for the daily synchronization of tissues: an autonomous response branch, whereby light entrains circadian clocks without any commitment of other Bmal1-dependent clocks, and a memory branch using other Bmal1-dependent clocks to “remember” time in the absence of external cues.  
  Address Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology, 08028 Barcelona, Spain; ICREA, Catalan Institution for Research and Advanced Studies, 08010 Barcelona, Spain. Electronic address: salvador.aznar-benitah@irbbarcelona.org  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0092-8674 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:31150620 Approved no  
  Call Number GFZ @ kyba @ Serial 2513  
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Author Bapary, M.A.J.; Takano, J.-I.; Soma, S.; Sankai, T. url  doi
openurl 
  Title Effect of blue LED light and antioxidants potential in a somatic cell Type Journal Article
  Year 2019 Publication (up) Cell Biology International Abbreviated Journal Cell Biol Int  
  Volume 43 Issue 11 Pages 1296-1306  
  Keywords Cells; Biology; LED; blue light; Antioxidants; cell death  
  Abstract Light is an indispensable part of routine laboratory works in which conventional light is generally used. Light-emitting diodes (LEDs) have come to replace the conventional light thus could be a potent target in biomedical studies. Since blue light is a major component of visible light wavelength, in this study, using a somatic cell from African green monkey kidney, we assessed the possible consequences of blue spectra of LED light in future animal experiments and proposed a potent mitigation against light induced damages. COS-7 cells were exposed to blue LED light (450 nm) and the growth and DNA damage were assessed at different exposure times. A higher suppression in cell growth and viability was observed under a longer period of blue LED light exposure. The number of apoptotic cells increased as light exposure time was prolonged. Reactive oxygen species generation was also elevated in accordance to the extension of light exposure times. A comparison to dark-maintained cells revealed that the upregulation of ROS by blue LED light plays a significant role in causing cellular dysfunction in DNA in a time-dependent manner. In turn, antioxidant treatment has shown to improve the cell growth and viability under blue LED light conditions. This indicates that antioxidants are potential against blue LED light-induced somatic cell damage. It is expected that this study will contribute to the understanding of the basic mechanism of somatic cell death under visible light and to maximize the beneficial use of LED light in future animal experiments.  
  Address Tsukuba Primate Research Center, National Institutes of Biomedical Innovation, Health and Nutrition, Ibaraki, Japan  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1065-6995 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:30958611 Approved no  
  Call Number GFZ @ kyba @ Serial 2328  
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