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Author |
Taufique, S.K.T.; Prabhat, A.; Kumar, V. |

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Title |
Illuminated night alters hippocampal gene expressions and induces depressive-like responses in diurnal corvids |
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Journal Article |
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Year |
2018 |
Publication |
The European Journal of Neuroscience |
Abbreviated Journal |
Eur J Neurosci |
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in press |
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in press |
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Animals |
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Artificial light at night induces circadian disruptions and causes cognitive impairment and mood disorders; yet very little is known about the neural and molecular correlates of these effects in diurnal animals. We manipulated the night environment and examined cellular and molecular changes in hippocampus, the brain region involved in cognition and mood, of Indian house crows (Corvus splendens) exposed to 12 h light (150 lux): 12 h darkness (0 lux). Diurnal corvids are an ideal model species with cognitive abilities at par with mammals. Dim light (6 lux) at night (dLAN) altered daily activity:rest pattern, reduced sleep and induced depressive-like responses (decreased eating and self-grooming, self-mutilation and reduced novel object exploration); return to an absolute dark night reversed these negative effects. dLAN suppressed nocturnal melatonin levels, however, diurnal corticosterone levels were unaffected. Concomitant reduction of immunoreactivity for DCX and BDNF suggested dLAN-induced suppression of hippocampal neurogenesis and compromised neuronal health. dLAN also negatively influenced hippocampal expression of genes associated with depressive-like responses (bdnf, il-1beta, tnfr1, nr4a2), but not of those associated with neuronal plasticity (egr1, creb, syngap, syn2, grin2a, grin2b), cellular oxidative stress (gst, sod3, cat1) and neuronal death (caspase2, caspase3, foxo3). Furthermore, we envisaged the role of BDNF and showed epigenetic modification of bdnf gene by decreased histone H3 acetylation and increased hdac4 expression under dLAN. These results demonstrate transcriptional and epigenetic bases of dLAN-induced negative effects in diurnal crows, and provide insights into the risks of exposure to illuminated nights to animals including humans in an urban setting. This article is protected by copyright. All rights reserved. |
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IndoUS Center for Biological Timing Department of Zoology, University of Delhi, Delhi, 110 007, India |
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0953-816X |
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PMID:30218624 |
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GFZ @ kyba @ |
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2010 |
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Author |
Park, C.Y. |

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Title |
Night Light Pollution and Ocular Fatigue |
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Journal Article |
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Year |
2018 |
Publication |
Journal of Korean Medical Science |
Abbreviated Journal |
J Korean Med Sci |
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33 |
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38 |
Pages |
e257 |
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Keywords |
Commentary; Human Health |
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Department of Ophthalmology, Dongguk University, Ilsan Hospital, Goyang, Korea |
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1011-8934 |
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PMID:30220898; PMCID:PMC6137033 |
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GFZ @ kyba @ |
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2011 |
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McGlashan, E.M.; Nandam, L.S.; Vidafar, P.; Mansfield, D.R.; Rajaratnam, S.M.W.; Cain, S.W. |

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Title |
The SSRI citalopram increases the sensitivity of the human circadian system to light in an acute dose |
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Journal Article |
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Year |
2018 |
Publication |
Psychopharmacology |
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Psychopharmacology (Berl) |
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in press |
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in press |
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Human Health |
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RATIONALE: Disturbances of the circadian system are common in depression. Though they typically subside when depression is treated with antidepressants, the mechanism by which this occurs is unknown. Despite being the most commonly prescribed class of antidepressants, the effect of selective serotonin reuptake inhibitors (SSRIs) on the human circadian clock is not well understood. OBJECTIVE: To examine the effect of the SSRI citalopram (30 mg) on the sensitivity of the human circadian system to light. METHODS: This study used a double-blind, placebo-controlled, within-subjects, crossover design. Participants completed two melatonin suppression assessments in room level light (~ 100 lx), taking either a single dose of citalopram 30 mg or a placebo at the beginning of each light exposure. Melatonin suppression was calculated by comparing placebo and citalopram light exposure conditions to a dim light baseline. RESULTS: A 47% increase in melatonin suppression was observed after administration of an acute dose of citalopram, with all participants showing more suppression after citalopram administration (large effect, d = 1.54). Further, melatonin onset occurred later under normal room light with citalopram compared to placebo. CONCLUSIONS: Increased sensitivity of the circadian system to light could assist in explaining some of the inter-individual variability in antidepressant treatment responses, as it is likely to assist in recovery in some patients, while causing further disruption for others. |
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Monash Institute of Cognitive and Clinical Neurosciences, School of Psychological Sciences, Monash University, 18 Innovation Walk, Clayton, VIC, 3800, Australia. sean.cain@monash.edu |
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0033-3158 |
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PMID:30219986 |
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GFZ @ kyba @ |
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2012 |
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Kurvers, R.H.J.M.; Drägestein, J.; Hölker, F.; Jechow, A.; Krause, J.; Bierbach, D. |

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Title |
Artificial Light at Night Affects Emergence from a Refuge and Space Use in Guppies |
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Journal Article |
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Year |
2018 |
Publication |
Scientific Reports |
Abbreviated Journal |
Sci Rep |
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8 |
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1 |
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Animals |
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Artificial light at night (ALAN) is a major form of anthropogenic pollution. ALAN is well known to affect different behaviours during nighttime, when changes in light conditions often have immediate consequences for the trade-offs individuals experience. How ALAN affects daytime behaviours, however, has received far less attention. Here we studied how ALAN affected daytime personality traits and learning ability. We exposed Trinidadian guppies, Poecilia reticulata, for 10 weeks to different ALAN levels: bright light (24 hrs bright light, ~5,000 lx), dim light (12 hrs bright light; 12 hrs dim light, ~0.5 lx) and control (12 hrs bright light; 12 hrs dark). Afterwards, we tested how the treatments affected diurnal emergence from a refuge, space use, activity, sociability and the ability to memorize the location of companion fish. Individuals exposed to the light treatments (both dim and bright light) emerged quicker from a refuge and fish from the bright light treatment spent relatively more time in the open area of the arena. ALAN did not affect any of the other behaviours, although memory could not be tested since fish did not learn the companions’ location. Our results demonstrate that ALAN, next to affecting nocturnal behaviours, can also affect key diurnal behavioural processes, associated with risk-taking. |
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2045-2322 |
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GFZ @ kyba @ |
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2013 |
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Author |
Kinzey, B.R.; Perrin, T.E.; Miller, N.J.; Kocifaj, M.; Aubé, M.; Lamphar, H.A. |
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Title |
An investigation of LED street lighting's impact on sky glow |
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Journal Article |
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2017 |
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PNNL-26411 |
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Skyglow; Lighting |
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A significant amount of public attention has recently focused on perceived impacts of converting street lighting from incumbent lamp-based products to LED technology. Much of this attention pertains to the higher content of short wavelength light (commonly referred to as “blue light”) of LEDs and its attendant influences on sky glow (a brightening of the night sky that can interfere with astronomical observation and may be associated with a host of other issues). The complexity of this topic leads to common misunderstandings and misperceptions among the public, and for this reason the U.S. Department of Energy Solid-State Lighting Program embarked on a study of sky glow using a well-established astronomical model to investigate some of the primary factors influencing sky glow. This report details the results of the investigation and attempts to present those results in terms accessible to the general lighting community. The report also strives to put the results into a larger context, and help educate interested readers on various topics relevant to the issues being discussed. |
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Pacific Northwest National Lab. (PNNL), Richland, WA (United States) |
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GFZ @ kyba @ |
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2014 |
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