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Stevens, R.G. |
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Comment on 'Domestic light at night and breast cancer risk: a prospective analysis of 105 000 UK women in the Generations Study' |
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Journal Article |
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2018 |
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British Journal of Cancer |
Abbreviated Journal |
Br J Cancer |
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in press |
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Commentary; Human Health |
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University of Connecticut, School of Medicine, 263 Farmington Avenue, Farmington, CT, 06032, USA. bugs@uchc.edu |
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0007-0920 |
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PMID:30283145 |
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GFZ @ kyba @ |
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2035 |
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Author |
Leise, T.L.; Goldberg, A.; Michael, J.; Montoya, G.; Solow, S.; Molyneux, P.; Vetrivelan, R.; Harrington, M.E. |
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Title |
Recurring circadian disruption alters circadian clock sensitivity to resetting |
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Journal Article |
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2018 |
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The European Journal of Neuroscience |
Abbreviated Journal |
Eur J Neurosci |
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in press |
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Animals |
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A single phase advance of the light:dark (LD) cycle can temporarily disrupt synchrony of neural circadian rhythms within the suprachiasmatic nucleus (SCN) and between the SCN and peripheral tissues. Compounding this, modern life can involve repeated disruptive light conditions. To model chronic disruption to the circadian system, we exposed male mice to more than a month of a 20 h light cycle (LD10:10), which mice typically cannot entrain to. Control animals were housed under LD12:12. We measured locomotor activity and body temperature rhythms in vivo, and rhythms of PER2::LUC bioluminescence in SCN and peripheral tissues ex vivo. Unexpectedly, we discovered strong effects of the time of dissection on circadian phase of PER2::LUC bioluminescent rhythms, which varied across tissues. White adipose tissue was strongly reset by dissection, while thymus phase appeared independent of dissection timing. Prior light exposure impacted the SCN, resulting in strong resetting of SCN phase by dissection for mice housed under LD10:10, and weak phase shifts by time of dissection in SCN from control LD12:12 mice. These findings suggest that exposure to circadian disruption may desynchronize SCN neurons, increasing network sensitivity to perturbations. We propose that tissues with a weakened circadian network, such as the SCN under disruptive light conditions, or with little to no coupling, e.g., some peripheral tissues, will show increased resetting effects. In particular, exposure to light at inconsistent circadian times on a recurring weekly basis disrupts circadian rhythms and alters sensitivity of the SCN neural pacemaker to dissection time. This article is protected by copyright. All rights reserved. |
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Neuroscience Program, Smith College, Northampton, MA, 01063, USA |
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0953-816X |
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PMID:30269396 |
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GFZ @ kyba @ |
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2036 |
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Author |
Wurtman, R.J. |
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Title |
The Pineal and Endocrine Function |
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Journal Article |
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Year |
1969 |
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Hospital Practice |
Abbreviated Journal |
Hospital Practice |
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4 |
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1 |
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32-37 |
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Human Health |
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Recognition that levels of hormonal secretion vary markedly from day to night has triggered intensive investigation into the influence of environmental light upon endocrine function. These studies have pointed to the pineal gland as a major mediator of a wide variety of hormonal responses involving the gonads, thyroid, and pituitary, and the hypothalamus and other regions of the brain. |
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Human Health |
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2154-8331 |
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GFZ @ kyba @ |
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2037 |
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Author |
Li, K.; Chen, Y.; Li, Y. |
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The Random Forest-Based Method of Fine-Resolution Population Spatialization by Using the International Space Station Nighttime Photography and Social Sensing Data |
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Journal Article |
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2018 |
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Remote Sensing |
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Remote Sensing |
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10 |
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10 |
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1650 |
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Remote Sensing |
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Despite the importance of high-resolution population distribution in urban planning, disaster prevention and response, region economic development, and improvement of urban habitant environment, traditional urban investigations mainly focused on large-scale population spatialization by using coarse-resolution nighttime light (NTL) while few efforts were made to fine-resolution population mapping. To address problems of generating small-scale population distribution, this paper proposed a method based on the Random Forest Regression model to spatialize a 25 m population from the International Space Station (ISS) photography and urban function zones generated from social sensing data—point-of-interest (POI). There were three main steps, namely HSL (hue saturation lightness) transformation and saturation calibration of ISS, generating functional-zone maps based on point-of-interest, and spatializing population based on the Random Forest model. After accuracy assessments by comparing with WorldPop, the proposed method was validated as a qualified method to generate fine-resolution population spatial maps. In the discussion, this paper suggested that without help of auxiliary data, NTL cannot be directly employed as a population indicator at small scale. The Variable Importance Measure of the RF model confirmed the correlation between features and population and further demonstrated that urban functions performed better than LULC (Land Use and Land Cover) in small-scale population mapping. Urban height was also shown to improve the performance of population disaggregation due to its compensation of building volume. To sum up, this proposed method showed great potential to disaggregate fine-resolution population and other urban socio-economic attributes. |
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2072-4292 |
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GFZ @ kyba @ |
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2038 |
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Author |
Kozaki, T.; Hidaka, Y.; Takakura, J.-Y.; Kusano, Y. |
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Title |
Suppression of salivary melatonin secretion under 100-Hz flickering and non-flickering blue light |
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Journal Article |
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Year |
2018 |
Publication |
Journal of Physiological Anthropology |
Abbreviated Journal |
J Physiol Anthropol |
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Volume |
37 |
Issue |
1 |
Pages |
23 |
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Keywords |
Human Health |
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BACKGROUND: Bright light at night is known to suppress melatonin secretion. Novel photoreceptors named intrinsically photosensitive retinal ganglion cells (ipRGCs) are mainly responsible for projecting dark/bright information to the suprachiasmatic nucleus and thus regulating the circadian system. However, it has been shown that the amplitude of the electroretinogram of ipRGCs is considerably lower under flickering light at 100 Hz than at 1-5 Hz, suggesting that flickering light may also affect the circadian system. Therefore, in this study, we evaluated light-induced melatonin suppression under flickering and non-flickering light. METHODS: Twelve male participants between the ages of 20 and 23 years (mean +/- S.D. = 21.6 +/- 1.5 years) were exposed to three light conditions (dim, 100-Hz flickering, and non-flickering blue light) from 1:00 A.M. to 2:30 A.M., and saliva samples were obtained just before 1:00 A.M. and at 1:15, 1:30, 2:00, and 2:30 A.M. RESULTS: A repeated measures t test with Bonferroni correction showed that at 1:15 A.M., melatonin concentrations were significantly lower following exposure to non-flickering light compared with dim light, whereas there was no significant difference between the dim and 100-Hz flickering light conditions. By contrast, after 1:30 A.M., the mean melatonin concentrations were significantly lower under both 100-Hz flickering and non-flickering light than under dim light. CONCLUSION: Although melatonin suppression rate tended to be lower under 100-Hz flickering light than under non-flickering light at the initial 15 min of the light exposure, the present study suggests that 100-Hz flickering light may have the same impact on melatonin secretion as non-flickering light. |
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Department of Health and Nutrition Sciences, Nishikyushu University, Kanzaki, Japan |
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1880-6791 |
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PMID:30340620 |
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GFZ @ kyba @ |
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2039 |
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