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Author Filipski, E.; Subramanian, P.; Carriere, J.; Guettier, C.; Barbason, H.; Levi, F. url  doi
openurl 
  Title Circadian disruption accelerates liver carcinogenesis in mice Type Journal Article
  Year 2009 Publication Mutation Research Abbreviated Journal Mutat Res  
  Volume 680 Issue 1-2 Pages 95-105  
  Keywords Human Health; Animals; Alanine Transaminase/blood; Animals; Aspartate Aminotransferases/blood; Bile Duct Neoplasms/chemically induced/pathology; Bile Ducts, Intrahepatic/drug effects/pathology; Body Weight/drug effects; Carcinogens/administration & dosage/*toxicity; Carcinoma, Hepatocellular/chemically induced/pathology; Cholangiocarcinoma/chemically induced/pathology; Circadian Rhythm/*drug effects; Diethylnitrosamine/administration & dosage/*toxicity; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Liver/drug effects/pathology; Liver Neoplasms/blood/*chemically induced/pathology; Male; Mice; Neoplasms, Multiple Primary/chemically induced/pathology; Sarcoma/chemically induced/pathology; Time Factors  
  Abstract BACKGROUND: The circadian timing system rhythmically controls behavior, physiology, cellular proliferation and xenobiotic metabolism over the 24-h period. The suprachiasmatic nuclei in the hypothalamus coordinate the molecular clocks in most mammalian cells through an array of circadian physiological rhythms including rest-activity, body temperature, feeding patterns and hormonal secretions. As a result, shift work that involves circadian disruption is probably carcinogenic in humans. In experimental models, chronic jet-lag (CJL) suppresses rest-activity and body temperature rhythms and accelerates growth of two transplantable tumors in mice. CJL also suppresses or significantly alters the expression rhythms of clock genes in liver and tumors. Circadian clock disruption from CJL downregulates p53 and upregulates c-Myc, thus favoring cellular proliferation. Here, we investigate the role of CJL as a tumor promoter in mice exposed to the hepatic carcinogen, diethylnitrosamine (DEN). METHODS: In experiment 1 (Exp 1), the dose-dependent carcinogenicity of chronic intraperitoneal (i.p.) administration of DEN was explored in mice. In Exp 2, mice received DEN at 10 mg/kg/day (cumulative dose: 243 mg/kg), then were randomized to remain in a photoperiodic regimen where 12 h of light alternates with 12 h of darkness (LD 12:12) or to be submitted to CJL (8-h advance of light onset every 2 days). Rest-activity and body temperature were monitored. Serum liver enzymes were determined repeatedly. Mice were sacrificed and examined for neoplastic lesions at 10 months. RESULTS: In Exp 1, DEN produced liver cancers in all the mice receiving 10 mg/kg/day. In Exp 2, mice on CJL had increased mean plasma levels of aspartate aminotransferase and more liver tumors as compared to LD mice at approximately 10 months (p = 0.005 and 0.028, respectively). The mean diameter of the largest liver tumor was twice as large in CJL vs LD mice (8.5 vs 4.4 mm, p = 0.027). In LD, a single histologic tumor type per liver was observed. In CJL, up to four different types were associated in the same liver (hepatocellular- or cholangio-carcinomas, sarcomas or mixed tumors). DEN itself markedly disrupted the circadian rhythms in rest-activity and body temperature in all the mice. DEN-induced disruption was prolonged for >or= 3 months by CJL exposure. CONCLUSIONS: The association of circadian disruption with chronic DEN exposure suggests that circadian clocks actively control the mechanisms of liver carcinogenesis in mice. Persistent circadian coordination may further be critical for slowing down and/or reverting cancer development after carcinogen exposure.  
  Address INSERM, U776 Rythmes Biologiques et Cancers, Hopital Paul Brousse, Villejuif F-94807, France  
  Corporate Author Thesis (up)  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0027-5107 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:19833225 Approved no  
  Call Number LoNNe @ kagoburian @ Serial 747  
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Author Holzhauer S.I.J.; Franke S.; Kyba C.C.M.; Manfrin A.; Klenke R.; Voigt C.C.; Lewanzik D.; Oehlert M.; Monaghan M.T.; Schneider S.; Heller S.; Kuechly H.; Brüning A.; Honnen A.-C.; Hölker F. url  doi
openurl 
  Title Out of the Dark: Establishing a Large-Scale Field Experiment to Assess the Effects of Artificial Light at Night on Species and Food Webs Type Journal Article
  Year 2015 Publication Sustainability Abbreviated Journal  
  Volume 7 Issue 11 Pages 15593-15616  
  Keywords ALAN; artificial light at night; ecosystems; freshwater; light pollution; loss of the night; photometric characterization; riparian; Verlust der Nacht  
  Abstract Artificial light at night (ALAN) is one of the most obvious hallmarks of human presence in an ecosystem. The rapidly increasing use of artificial light has fundamentally transformed nightscapes throughout most of the globe, although little is known about how ALAN impacts the biodiversity and food webs of illuminated ecosystems. We developed a large-scale experimental infrastructure to study the effects of ALAN on a light-naïve, natural riparian (i.e., terrestrial-aquatic) ecosystem. Twelve street lights (20 m apart) arranged in three rows parallel to an agricultural drainage ditch were installed on each of two sites located in a grassland ecosystem in northern Germany. A range of biotic, abiotic, and photometric data are collected regularly to study the short- and long-term effects of ALAN on behavior, species interactions, physiology, and species composition of communities. Here we describe the infrastructure setup and data collection methods, and characterize the study area including photometric measurements. None of the measured parameters differed significantly between sites in the period before illumination. Results of one short-term experiment, carried out with one site illuminated and the other acting as a control, demonstrate the attraction of ALAN by the immense and immediate increase of insect catches at the lit street lights. The experimental setup provides a unique platform for carrying out interdisciplinary research on sustainable lighting.  
  Address Leibniz Institute of Freshwater Ecology and Inland Fisheries (IGB), Müggelseedamm 301/310, 12587 Berlin, Germany; holzhauer(at)igb-berlin.de  
  Corporate Author Thesis (up)  
  Publisher MDPI Place of Publication Editor  
  Language English Summary Language English Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number LoNNe @ schroer @ Serial 1305  
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Author Shapira, I.; Walker, E.; Brunton, D.H.; Raubenheimer, D. url  openurl
  Title Responses to direct versus indirect cues of predation and competition in naϊve invasive mice: implications for management Type Journal Article
  Year 2013 Publication New Zealand Journal of Ecology Abbreviated Journal NZ J. of Ecol.  
  Volume 37 Issue 1 Pages 33-40  
  Keywords Animals; Mus musculus; mice; New Zealand; foraging; moonlight; giving-up density; GUD; moon phase  
  Abstract Many populations of invasive mice Mus musculus in New Zealand have experienced the removal of mammalian predators and competitors, with the consequence of mouse population irruptions. The effects of these removals on mouse foraging are largely unknown, yet this information is essential for developing and implementing better mouse control. We investigated the effects of direct and indirect predatory cues on foraging of free-ranging mice at a site where mammalian predators were eradicated 5 years previously. We used 17 stations, each containing four trays of millet seeds mixed thoroughly in sand, with three unfamiliar mammalian (a predator, a competitor, and a herbivore) odour treatments and a control (water), during the four phases of the moon. We measured mouse selectivity for treatment/control trays, giving-up densities (GUDs, a measure of food consumption), and tray encounter rates. Foraging by mice was not affected by odour cues from any of the unfamiliar mammals. Moonlight intensity, however, affected mouse foraging, with higher GUDs being recorded on brighter moon phases (full and waxing > new and waning) during the first night of the trials. This effect was less pronounced during the second night. Resource encounter rates were also affected, with the proportion of trays foraged lower during the brighter phases of the moon on both the first and second nights. We suggest that coordinating management efforts according to the phases of the moon has the potential to improve mouse control and reduce bait wastage.  
  Address  
  Corporate Author Thesis (up)  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 01106465 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number IDA @ john @ Serial 1364  
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Author Schroer, S.; Hölker, F. url  doi
isbn  openurl
  Title Impact of Lighting on Flora and Fauna Type Book Chapter
  Year 2016 Publication Handbook of Advanced Lighting Technology Abbreviated Journal  
  Volume Issue Pages 1-33  
  Keywords Ecology; Lighting; Artificial light at night; ALAN; Plants; Animals; review  
  Abstract Technology, especially artificial light at night (ALAN), often has unexpected impacts on the environment. This chapter addresses both the perception of light by various organisms and the impact of ALAN on flora and fauna. The responses to ALAN are subdivided into the effects of light intensity, color spectra, and duration and timing of illumination. The ways organisms perceive light can be as variable as the habitats they live in. ALAN often interferes with natural light information. It is rarely neutral and has significant impacts beyond human perception. For example, UV light reflection of generative plant parts or the direction of light is used by many organisms as information for foraging, finding spawning sites, or communication. Contemporary outdoor lighting often lacks sustainable planning, even though the protection of species, habitat, and human well-being could be improved by adopting simple technical measures. The increasing use of ALAN with high intensities in the blue part of the spectrum, e.g., fluorescent light and LEDs, is discussed as a critical trend. Blue light is a major circadian signal in higher vertebrates and can substantially impact the orientation of organisms such as numerous insect species. A better understanding of how various types and sources of artificial light, and how organisms perceive ALAN, will be an important step towards more sustainable lighting. Such knowledge is the basis for sustainable lighting planning and the development of solutions to protect biodiversity from the effects of outdoor lighting. Maps that describe the rapid changes in ALAN are urgently needed. In addition, measures are required to reduce the increasing use and intensity of ALAN in more remote areas as signaling thresholds in flora and fauna at night are often close to moonlight intensity and far below streetlight levels.  
  Address Leibniz Institute of Freshwater Ecology and Inland Fisheries, Müggelseedamm 310, 12587, Berlin, Germany; schroer(at)igb-berlin.de  
  Corporate Author Thesis (up)  
  Publisher Springer Place of Publication Editor  
  Language English Summary Language English Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN 978-3-319-00295-8 Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number IDA @ john @ Serial 1470  
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Author Ouyang, J.Q.; Davies, S.; Dominoni, D. url  doi
openurl 
  Title Hormonally mediated effects of artificial light at night on behavior and fitness: linking endocrine mechanisms with function Type Journal Article
  Year 2018 Publication The Journal of Experimental Biology Abbreviated Journal J Exp Biol  
  Volume 221 Issue Pt 6 Pages  
  Keywords Human Health; Alan; Glucocorticoid; Hormones; Light pollution; Melatonin; Metabolism; Sleep; Stress; Thyroid; Urban ecology  
  Abstract Alternation between day and night is a predictable environmental fluctuation that organisms use to time their activities. Since the invention of artificial lighting, this predictability has been disrupted and continues to change in a unidirectional fashion with increasing urbanization. As hormones mediate individual responses to changing environments, endocrine systems might be one of the first systems affected, as well as being the first line of defense to ameliorate any negative health impacts. In this Review, we first highlight how light can influence endocrine function in vertebrates. We then focus on four endocrine axes that might be affected by artificial light at night (ALAN): pineal, reproductive, adrenal and thyroid. Throughout, we highlight key findings, rather than performing an exhaustive review, in order to emphasize knowledge gaps that are hindering progress on proposing impactful and concrete plans to ameliorate the negative effects of ALAN. We discuss these findings with respect to impacts on human and animal health, with a focus on the consequences of anthropogenic modification of the night-time environment for non-human organisms. Lastly, we stress the need for the integration of field and lab experiments as well as the need for long-term integrative eco-physiological studies in the rapidly expanding field of light pollution.  
  Address Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, Glasgow G12 8QQ, UK;  
  Corporate Author Thesis (up)  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0022-0949 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:29545373 Approved no  
  Call Number IDA @ john @ Serial 1817  
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