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Author (up) Eisenstein, M.
Title Chronobiology: stepping out of time Type Journal Article
Year 2013 Publication Nature Abbreviated Journal Nature
Volume 497 Issue 7450 Pages S10-2
Keywords Human Health; Animals; Benzofurans/therapeutic use; CLOCK Proteins/genetics/metabolism; Circadian Rhythm/genetics/*physiology; Cyclopropanes/therapeutic use; Efficiency/physiology; Humans; Melatonin/agonists/metabolism; Obesity/metabolism; Sleep/genetics/*physiology; Suprachiasmatic Nucleus/metabolism
Abstract
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0028-0836 ISBN Medium
Area Expedition Conference
Notes PMID:23698500 Approved no
Call Number LoNNe @ christopher.kyba @ Serial 500
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Author (up) Kovac, J.; Husse, J.; Oster, H.
Title A time to fast, a time to feast: the crosstalk between metabolism and the circadian clock Type Journal Article
Year 2009 Publication Molecules and Cells Abbreviated Journal Mol Cells
Volume 28 Issue 2 Pages 75-80
Keywords Human Health; Animals; Biological Clocks/*physiology; CLOCK Proteins/genetics/metabolism; Circadian Rhythm/*physiology; Energy Metabolism/*physiology; Gene Expression Regulation; Homeostasis; Humans; Period Circadian Proteins/genetics/metabolism; Time Factors
Abstract The cyclic environmental conditions brought about by the 24 h rotation of the earth have allowed the evolution of endogenous circadian clocks that control the temporal alignment of behaviour and physiology, including the uptake and processing of nutrients. Both metabolic and circadian regulatory systems are built upon a complex feedback network connecting centres of the central nervous system and different peripheral tissues. Emerging evidence suggests that circadian clock function is closely linked to metabolic homeostasis and that rhythm disruption can contribute to the development of metabolic disease. At the same time, metabolic processes feed back into the circadian clock, affecting clock gene expression and timing of behaviour. In this review, we summarize the experimental evidence for this bimodal interaction, with a focus on the molecular mechanisms mediating this exchange, and outline the implications for clock-based and metabolic diseases.
Address Circadian Rhythms Group, Max Planck Institute of Biophysical Chemistry, 37077, Gottingen, Germany
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1016-8478 ISBN Medium
Area Expedition Conference
Notes PMID:19714310 Approved no
Call Number LoNNe @ kagoburian @ Serial 772
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Author (up) Owens, B.
Title Obesity: heavy sleepers Type Journal Article
Year 2013 Publication Nature Abbreviated Journal Nature
Volume 497 Issue 7450 Pages S8-9
Keywords Human Health; Animals; Body Mass Index; CLOCK Proteins/genetics/metabolism; Circadian Rhythm/physiology; Energy Metabolism/*physiology; Ghrelin/metabolism; Humans; Insulin Resistance/physiology; Leptin/metabolism; Male; Mice; Obesity/*physiopathology; Satiety Response/physiology; Sleep/*physiology; Suprachiasmatic Nucleus/physiology; Time Factors; Weight Gain/physiology; Weight Loss/physiology
Abstract
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0028-0836 ISBN Medium
Area Expedition Conference
Notes PMID:23698508 Approved no
Call Number LoNNe @ christopher.kyba @ Serial 503
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Author (up) Savvidis, C.; Koutsilieris, M.
Title Circadian rhythm disruption in cancer biology Type Journal Article
Year 2012 Publication Molecular Medicine (Cambridge, Mass.) Abbreviated Journal Mol Med
Volume 18 Issue Pages 1249-1260
Keywords Human Health; Animals; CLOCK Proteins/genetics/metabolism; Circadian Clocks/genetics; *Circadian Rhythm/genetics; Environment; Humans; Melatonin/metabolism; Neoplasms/genetics/pathology/*physiopathology/therapy
Abstract Circadian rhythms show universally a 24-h oscillation pattern in metabolic, physiological and behavioral functions of almost all species. This pattern is due to a fundamental adaptation to the rotation of Earth around its own axis. Molecular mechanisms of generation of circadian rhythms organize a biochemical network in suprachiasmatic nucleus and peripheral tissues, building cell autonomous clock pacemakers. Rhythmicity is observed in transcriptional expression of a wide range of clock-controlled genes that regulate a variety of normal cell functions, such as cell division and proliferation. Desynchrony of this rhythmicity seems to be implicated in several pathologic conditions, including tumorigenesis and progression of cancer. In 2007, the International Agency for Research on Cancer (IARC) categorized “shiftwork that involves circadian disruption [as] probably carcinogenic to humans” (Group 2A in the IARC classification system of carcinogenic potency of an agentagent) (Painting, Firefighting, and Shiftwork; IARC; 2007). This review discusses the potential relation between disruptions of normal circadian rhythms with genetic driving machinery of cancer. Elucidation of the role of clockwork disruption, such as exposure to light at night and sleep disruption, in cancer biology could be important in developing new targeted anticancer therapies, optimizing individualized chronotherapy and modifying lighting environment in workplaces or homes.
Address Department of Endocrinology and Metabolism, Hippocration General Hospital, Athens, Greece. csavvidis@med.uoa.gr
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1076-1551 ISBN Medium
Area Expedition Conference
Notes PMID:22811066; PMCID:PMC3521792 Approved no
Call Number LoNNe @ christopher.kyba @ Serial 514
Permanent link to this record