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Author Bapary, M.A.J.; Takano, J.-I.; Soma, S.; Sankai, T. url  doi
openurl 
  Title Effect of blue LED light and antioxidants potential in a somatic cell Type Journal Article
  Year 2019 Publication Cell Biology International Abbreviated Journal Cell Biol Int  
  Volume in press Issue Pages  
  Keywords Cells; Biology  
  Abstract Light is an indispensable part of routine laboratory works in which conventional light is generally used. Light-emitting diodes (LEDs) have come to replace the conventional light thus could be a potent target in biomedical studies. Since blue light is a major component of visible light wavelength, in this study, using a somatic cell from African green monkey kidney, we assessed the possible consequences of blue spectra of LED light in future animal experiments and proposed a potent mitigation against light induced damages. COS-7 cells were exposed to blue LED light (450 nm) and the growth and DNA damage were assessed at different exposure times. A higher suppression in cell growth and viability was observed under a longer period of blue LED light exposure. The number of apoptotic cells increased as light exposure time was prolonged. Reactive oxygen species generation was also elevated in accordance to the extension of light exposure times. A comparison to dark-maintained cells revealed that the upregulation of ROS by blue LED light plays a significant role in causing cellular dysfunction in DNA in a time-dependent manner. In turn, antioxidant treatment has shown to improve the cell growth and viability under blue LED light conditions. This indicates that antioxidants are potential against blue LED light-induced somatic cell damage. It is expected that this study will contribute to the understanding of the basic mechanism of somatic cell death under visible light and to maximize the beneficial use of LED light in future animal experiments. This article is protected by copyright. All rights reserved.  
  Address Tsukuba Primate Research Center, National Institutes of Biomedical Innovation, Health and Nutrition, Ibaraki, Japan  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN (down) 1065-6995 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:30958611 Approved no  
  Call Number GFZ @ kyba @ Serial 2328  
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Author Foster, R.G.; Hankins, M.W. url  doi
openurl 
  Title Circadian vision Type Journal Article
  Year 2007 Publication Current Biology : CB Abbreviated Journal Curr Biol  
  Volume 17 Issue 17 Pages R746-51  
  Keywords Human Health; Animals; Circadian Rhythm/*physiology; Mice; Photoreceptor Cells, Vertebrate/*physiology; Rats; Rod Opsins/physiology; Vision, Ocular/*physiology  
  Abstract  
  Address Department of Ophthalmology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. russell.foster@eye.ox.ac.uk  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN (down) 0960-9822 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:17803920 Approved no  
  Call Number LoNNe @ kagoburian @ Serial 751  
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Author Brainard, G.C.; Sliney, D.; Hanifin, J.P.; Glickman, G.; Byrne, B.; Greeson, J.M.; Jasser, S.; Gerner, E.; Rollag, M.D. url  doi
openurl 
  Title Sensitivity of the human circadian system to short-wavelength (420-nm) light Type Journal Article
  Year 2008 Publication Journal of Biological Rhythms Abbreviated Journal J Biol Rhythms  
  Volume 23 Issue 5 Pages 379-386  
  Keywords Human Health; Adult; Circadian Rhythm/*radiation effects; Female; Humans; *Light; Male; Melatonin/metabolism; Models, Biological; Neurosecretory Systems; Photons; Pineal Gland/metabolism; Retinal Ganglion Cells/*metabolism; Vision, Ocular  
  Abstract The circadian and neurobehavioral effects of light are primarily mediated by a retinal ganglion cell photoreceptor in the mammalian eye containing the photopigment melanopsin. Nine action spectrum studies using rodents, monkeys, and humans for these responses indicate peak sensitivities in the blue region of the visible spectrum ranging from 459 to 484 nm, with some disagreement in short-wavelength sensitivity of the spectrum. The aim of this work was to quantify the sensitivity of human volunteers to monochromatic 420-nm light for plasma melatonin suppression. Adult female (n=14) and male (n=12) subjects participated in 2 studies, each employing a within-subjects design. In a fluence-response study, subjects (n=8) were tested with 8 light irradiances at 420 nm ranging over a 4-log unit photon density range of 10(10) to 10(14) photons/cm(2)/sec and 1 dark exposure control night. In the other study, subjects (n=18) completed an experiment comparing melatonin suppression with equal photon doses (1.21 x 10(13) photons/cm(2)/sec) of 420 nm and 460 nm monochromatic light and a dark exposure control night. The first study demonstrated a clear fluence-response relationship between 420-nm light and melatonin suppression (p<0.001) with a half-saturation constant of 2.74 x 10(11) photons/cm(2)/sec. The second study showed that 460-nm light is significantly stronger than 420-nm light for suppressing melatonin (p<0.04). Together, the results clarify the visible short-wavelength sensitivity of the human melatonin suppression action spectrum. This basic physiological finding may be useful for optimizing lighting for therapeutic and other applications.  
  Address Department of Neurology, Thomas Jefferson University, Philadelphia, PA 19107, USA. george.brainard@jefferson.edu  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN (down) 0748-7304 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:18838601 Approved no  
  Call Number LoNNe @ kagoburian @ Serial 724  
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Author Lucas, R.J.; Peirson, S.N.; Berson, D.M.; Brown, T.M.; Cooper, H.M.; Czeisler, C.A.; Figueiro, M.G.; Gamlin, P.D.; Lockley, S.W.; O'Hagan, J.B.; Price, L.L.A.; Provencio, I.; Skene, D.J.; Brainard, G.C. url  doi
openurl 
  Title Measuring and using light in the melanopsin age Type Journal Article
  Year 2014 Publication Trends in Neurosciences Abbreviated Journal Trends Neurosci  
  Volume 37 Issue 1 Pages 1-9  
  Keywords Editorial; Animals; Circadian Rhythm/physiology; Humans; Photoreceptor Cells/metabolism; Phototherapy/*trends; Retinal Ganglion Cells/metabolism; Rod Opsins/*physiology  
  Abstract Light is a potent stimulus for regulating circadian, hormonal, and behavioral systems. In addition, light therapy is effective for certain affective disorders, sleep problems, and circadian rhythm disruption. These biological and behavioral effects of light are influenced by a distinct photoreceptor in the eye, melanopsin-containing intrinsically photosensitive retinal ganglion cells (ipRGCs), in addition to conventional rods and cones. We summarize the neurophysiology of this newly described sensory pathway and consider implications for the measurement, production, and application of light. A new light-measurement strategy taking account of the complex photoreceptive inputs to these non-visual responses is proposed for use by researchers, and simple suggestions for artificial/architectural lighting are provided for regulatory authorities, lighting manufacturers, designers, and engineers.  
  Address Department of Neurology, Thomas Jefferson University, Philidelphia, PA, USA. Electronic address: George.Brainard@jefferson.edu  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN (down) 0166-2236 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:24287308 Approved no  
  Call Number LoNNe @ christopher.kyba @ Serial 457  
Permanent link to this record
 

 
Author Meng, Y.; He, Z.; Yin, J.; Zhang, Y.; Zhang, T. url  doi
openurl 
  Title Quantitative calculation of human melatonin suppression induced by inappropriate light at night Type Journal Article
  Year 2011 Publication Medical & Biological Engineering & Computing Abbreviated Journal Med Biol Eng Comput  
  Volume 49 Issue 9 Pages 1083-1088  
  Keywords Algorithms; Circadian Rhythm/physiology/*radiation effects; Humans; *Lighting; Melatonin/*secretion; *Models, Biological; Retinal Cone Photoreceptor Cells/physiology/radiation effects; Retinal Ganglion Cells/physiology/radiation effects; Retinal Rod Photoreceptor Cells/physiology/radiation effects  
  Abstract Melatonin (C(1)(3)H(1)(6)N(2)O(2)) has a wide range of functions in the body. When is inappropriately exposed to light at night, human circadian rhythm will be interfered and then melatonin secretion will become abnormal. For nearly three decades great progresses have been achieved in analytic action spectra and melatonin suppression by various light conditions. However, so far few articles focused on the quantitative calculation of melatonin suppression induced by light. In this article, an algorithm is established, in which all the contributions of rods, cones, and intrinsically photosensitive retinal ganglion cells are considered. Calculation results accords with the experimental data in references very well, which indicate the validity of this algorithm. This algorithm can also interpret the rule of melatonin suppression varying with light correlated color temperature very well.  
  Address Photonics Research Center, School of Physics, Nankai University, Tianjin 300071, China  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN (down) 0140-0118 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:21717231 Approved no  
  Call Number IDA @ john @ Serial 236  
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