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Author Sherman, H.; Gutman, R.; Chapnik, N.; Meylan, J.; le Coutre, J.; Froy, O. url  doi
openurl 
  Title Caffeine alters circadian rhythms and expression of disease and metabolic markers Type Journal Article
  Year 2011 Publication The International Journal of Biochemistry & Cell Biology Abbreviated Journal Int J Biochem Cell Biol  
  Volume (down) 43 Issue 5 Pages 829-838  
  Keywords Human Health; Animals; Biological Markers/blood/metabolism; Body Weight/drug effects/physiology; Caffeine/*pharmacology; Caloric Restriction; Circadian Rhythm/*drug effects/genetics/physiology; *Disease/genetics; Eating/drug effects/physiology; Gene Expression Regulation/*drug effects/genetics; HEK293 Cells; Humans; Inflammation/metabolism; Male; Mice; Mice, Inbred C57BL; Motor Activity/drug effects/physiology  
  Abstract The circadian clock regulates many aspects of physiology, energy metabolism, and sleep. Restricted feeding (RF), a regimen that restricts the duration of food availability entrains the circadian clock. Caffeine has been shown to affect both metabolism and sleep. However, its effect on clock gene and clock-controlled gene expression has not been studied. Here, we tested the effect of caffeine on circadian rhythms and the expression of disease and metabolic markers in the serum, liver, and jejunum of mice supplemented with caffeine under ad libitum (AL) feeding or RF for 16 weeks. Caffeine significantly affected circadian oscillation and the daily levels of disease and metabolic markers. Under AL, caffeine reduced the average daily mRNA levels of certain disease and inflammatory markers, such as liver alpha fetoprotein (Afp), C-reactive protein (Crp), jejunum alanine aminotransferase (Alt), growth arrest and DNA damage 45beta (Gadd45beta), Interleukin 1alpha (Il-1alpha), Il-1beta mRNA and serum plasminogen activator inhibitor 1 (PAI-1). Under RF, caffeine reduced the average daily levels of Alt, Gadd45beta, Il-1alpha and Il-1beta mRNA in the jejunum, but not in the liver. In addition, caffeine supplementation led to decreased expression of catabolic factors under RF. In conclusion, caffeine affects circadian gene expression and metabolism possibly leading to beneficial effects mainly under AL feeding.  
  Address Institute of Biochemistry, Food Science and Nutrition, Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 76100, Israel  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1357-2725 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:21352949 Approved no  
  Call Number LoNNe @ kagoburian @ Serial 810  
Permanent link to this record
 

 
Author Bapary, M.A.J.; Takano, J.-I.; Soma, S.; Sankai, T. url  doi
openurl 
  Title Effect of blue LED light and antioxidants potential in a somatic cell Type Journal Article
  Year 2019 Publication Cell Biology International Abbreviated Journal Cell Biol Int  
  Volume (down) 43 Issue 11 Pages 1296-1306  
  Keywords Cells; Biology; LED; blue light; Antioxidants; cell death  
  Abstract Light is an indispensable part of routine laboratory works in which conventional light is generally used. Light-emitting diodes (LEDs) have come to replace the conventional light thus could be a potent target in biomedical studies. Since blue light is a major component of visible light wavelength, in this study, using a somatic cell from African green monkey kidney, we assessed the possible consequences of blue spectra of LED light in future animal experiments and proposed a potent mitigation against light induced damages. COS-7 cells were exposed to blue LED light (450 nm) and the growth and DNA damage were assessed at different exposure times. A higher suppression in cell growth and viability was observed under a longer period of blue LED light exposure. The number of apoptotic cells increased as light exposure time was prolonged. Reactive oxygen species generation was also elevated in accordance to the extension of light exposure times. A comparison to dark-maintained cells revealed that the upregulation of ROS by blue LED light plays a significant role in causing cellular dysfunction in DNA in a time-dependent manner. In turn, antioxidant treatment has shown to improve the cell growth and viability under blue LED light conditions. This indicates that antioxidants are potential against blue LED light-induced somatic cell damage. It is expected that this study will contribute to the understanding of the basic mechanism of somatic cell death under visible light and to maximize the beneficial use of LED light in future animal experiments.  
  Address Tsukuba Primate Research Center, National Institutes of Biomedical Innovation, Health and Nutrition, Ibaraki, Japan  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1065-6995 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:30958611 Approved no  
  Call Number GFZ @ kyba @ Serial 2328  
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Author Lucas, R.J.; Peirson, S.N.; Berson, D.M.; Brown, T.M.; Cooper, H.M.; Czeisler, C.A.; Figueiro, M.G.; Gamlin, P.D.; Lockley, S.W.; O'Hagan, J.B.; Price, L.L.A.; Provencio, I.; Skene, D.J.; Brainard, G.C. url  doi
openurl 
  Title Measuring and using light in the melanopsin age Type Journal Article
  Year 2014 Publication Trends in Neurosciences Abbreviated Journal Trends Neurosci  
  Volume (down) 37 Issue 1 Pages 1-9  
  Keywords Editorial; Animals; Circadian Rhythm/physiology; Humans; Photoreceptor Cells/metabolism; Phototherapy/*trends; Retinal Ganglion Cells/metabolism; Rod Opsins/*physiology  
  Abstract Light is a potent stimulus for regulating circadian, hormonal, and behavioral systems. In addition, light therapy is effective for certain affective disorders, sleep problems, and circadian rhythm disruption. These biological and behavioral effects of light are influenced by a distinct photoreceptor in the eye, melanopsin-containing intrinsically photosensitive retinal ganglion cells (ipRGCs), in addition to conventional rods and cones. We summarize the neurophysiology of this newly described sensory pathway and consider implications for the measurement, production, and application of light. A new light-measurement strategy taking account of the complex photoreceptive inputs to these non-visual responses is proposed for use by researchers, and simple suggestions for artificial/architectural lighting are provided for regulatory authorities, lighting manufacturers, designers, and engineers.  
  Address Department of Neurology, Thomas Jefferson University, Philidelphia, PA, USA. Electronic address: George.Brainard@jefferson.edu  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
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  Series Volume Series Issue Edition  
  ISSN 0166-2236 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:24287308 Approved no  
  Call Number LoNNe @ christopher.kyba @ Serial 457  
Permanent link to this record
 

 
Author Brainard, G.C.; Sliney, D.; Hanifin, J.P.; Glickman, G.; Byrne, B.; Greeson, J.M.; Jasser, S.; Gerner, E.; Rollag, M.D. url  doi
openurl 
  Title Sensitivity of the human circadian system to short-wavelength (420-nm) light Type Journal Article
  Year 2008 Publication Journal of Biological Rhythms Abbreviated Journal J Biol Rhythms  
  Volume (down) 23 Issue 5 Pages 379-386  
  Keywords Human Health; Adult; Circadian Rhythm/*radiation effects; Female; Humans; *Light; Male; Melatonin/metabolism; Models, Biological; Neurosecretory Systems; Photons; Pineal Gland/metabolism; Retinal Ganglion Cells/*metabolism; Vision, Ocular  
  Abstract The circadian and neurobehavioral effects of light are primarily mediated by a retinal ganglion cell photoreceptor in the mammalian eye containing the photopigment melanopsin. Nine action spectrum studies using rodents, monkeys, and humans for these responses indicate peak sensitivities in the blue region of the visible spectrum ranging from 459 to 484 nm, with some disagreement in short-wavelength sensitivity of the spectrum. The aim of this work was to quantify the sensitivity of human volunteers to monochromatic 420-nm light for plasma melatonin suppression. Adult female (n=14) and male (n=12) subjects participated in 2 studies, each employing a within-subjects design. In a fluence-response study, subjects (n=8) were tested with 8 light irradiances at 420 nm ranging over a 4-log unit photon density range of 10(10) to 10(14) photons/cm(2)/sec and 1 dark exposure control night. In the other study, subjects (n=18) completed an experiment comparing melatonin suppression with equal photon doses (1.21 x 10(13) photons/cm(2)/sec) of 420 nm and 460 nm monochromatic light and a dark exposure control night. The first study demonstrated a clear fluence-response relationship between 420-nm light and melatonin suppression (p<0.001) with a half-saturation constant of 2.74 x 10(11) photons/cm(2)/sec. The second study showed that 460-nm light is significantly stronger than 420-nm light for suppressing melatonin (p<0.04). Together, the results clarify the visible short-wavelength sensitivity of the human melatonin suppression action spectrum. This basic physiological finding may be useful for optimizing lighting for therapeutic and other applications.  
  Address Department of Neurology, Thomas Jefferson University, Philadelphia, PA 19107, USA. george.brainard@jefferson.edu  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
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  Series Volume Series Issue Edition  
  ISSN 0748-7304 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:18838601 Approved no  
  Call Number LoNNe @ kagoburian @ Serial 724  
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Author Foster, R.G.; Hankins, M.W. url  doi
openurl 
  Title Circadian vision Type Journal Article
  Year 2007 Publication Current Biology : CB Abbreviated Journal Curr Biol  
  Volume (down) 17 Issue 17 Pages R746-51  
  Keywords Human Health; Animals; Circadian Rhythm/*physiology; Mice; Photoreceptor Cells, Vertebrate/*physiology; Rats; Rod Opsins/physiology; Vision, Ocular/*physiology  
  Abstract  
  Address Department of Ophthalmology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. russell.foster@eye.ox.ac.uk  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0960-9822 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:17803920 Approved no  
  Call Number LoNNe @ kagoburian @ Serial 751  
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