| Records |
Author  |
Foster, R.G. |
| Title |
Neurobiology: bright blue times |
Type |
Journal Article |
| Year |
2005 |
Publication |
Nature |
Abbreviated Journal |
Nature |
| Volume |
433 |
Issue |
7027 |
Pages |
698-699 |
| Keywords |
Human Health; Animals; Circadian Rhythm/physiology/radiation effects; Color Perception/physiology/*radiation effects; Humans; *Light; Light Signal Transduction/*radiation effects; Mice; Retinal Ganglion Cells/cytology/physiology/radiation effects; Retinaldehyde/chemistry/metabolism; Rod Opsins/*metabolism; NASA Discipline Space Human Factors; Non-NASA Center |
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Place of Publication |
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| Language |
English |
Summary Language |
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Original Title |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
0028-0836 |
ISBN |
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Expedition |
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Conference |
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| Notes |
PMID:15716938 |
Approved |
no |
| Call Number |
LoNNe @ kagoburian @ |
Serial |
750 |
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| Author |
Czeisler, C.A. |
| Title |
Perspective: casting light on sleep deficiency |
Type |
Journal Article |
| Year |
2013 |
Publication |
Nature |
Abbreviated Journal |
Nature |
| Volume |
497 |
Issue |
7450 |
Pages |
S13 |
| Keywords |
Human Health; Circadian Rhythm/physiology/radiation effects; Electricity/adverse effects; Humans; Jet Lag Syndrome/etiology/physiopathology/therapy; Lighting/*adverse effects; Melatonin/metabolism/secretion; Phototherapy; Sleep Deprivation/epidemiology/*etiology/*physiopathology/therapy; Suprachiasmatic Nucleus/physiology/radiation effects |
| Abstract |
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| Address |
Division of Sleep Medicine, Harvard Medical School, and Division of Sleep Medicine, Department of Medicine, Brigham and Women's Hospital, in Boston, Massachusetts, USA. charles_czeisler@hms.harvard.edu |
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Place of Publication |
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English |
Summary Language |
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Original Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
0028-0836 |
ISBN |
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| Notes |
PMID:23698501 |
Approved |
no |
| Call Number |
LoNNe @ christopher.kyba @ |
Serial |
499 |
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| Author |
Cajochen, C.; Munch, M.; Kobialka, S.; Krauchi, K.; Steiner, R.; Oelhafen, P.; Orgul, S.; Wirz-Justice, A. |
| Title |
High sensitivity of human melatonin, alertness, thermoregulation, and heart rate to short wavelength light |
Type |
Journal Article |
| Year |
2005 |
Publication |
The Journal of Clinical Endocrinology and Metabolism |
Abbreviated Journal |
J Clin Endocrinol Metab |
| Volume |
90 |
Issue |
3 |
Pages |
1311-1316 |
| Keywords |
Human Health; Adult; Body Temperature Regulation/physiology/*radiation effects; Circadian Rhythm/physiology/radiation effects; Color; Heart Rate/physiology/*radiation effects; Humans; *Light; Male; Melatonin/*metabolism; Retinal Cone Photoreceptor Cells/physiology; Sleep Stages/physiology/radiation effects; Wakefulness/physiology/*radiation effects |
| Abstract |
Light can elicit acute physiological and alerting responses in humans, the magnitude of which depends on the timing, intensity, and duration of light exposure. Here, we report that the alerting response of light as well as its effects on thermoregulation and heart rate are also wavelength dependent. Exposure to 2 h of monochromatic light at 460 nm in the late evening induced a significantly greater melatonin suppression than occurred with 550-nm monochromatic light, concomitant with a significantly greater alerting response and increased core body temperature and heart rate ( approximately 2.8 x 10(13) photons/cm(2)/sec for each light treatment). Light diminished the distal-proximal skin temperature gradient, a measure of the degree of vasoconstriction, independent of wavelength. Nonclassical ocular photoreceptors with peak sensitivity around 460 nm have been found to regulate circadian rhythm function as measured by melatonin suppression and phase shifting. Our findings-that the sensitivity of the human alerting response to light and its thermoregulatory sequelae are blue-shifted relative to the three-cone visual photopic system-indicate an additional role for these novel photoreceptors in modifying human alertness, thermophysiology, and heart rate. |
| Address |
Centre for Chronobiology, Psychiatric University Clinic, Wilhelm Kleinstr. 27, CH-4025 Basel, Switzerland. christian.cajochen@pukbasel.ch |
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English |
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Edition |
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| ISSN |
0021-972X |
ISBN |
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Expedition |
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Conference |
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| Notes |
PMID:15585546 |
Approved |
no |
| Call Number |
LoNNe @ kagoburian @ |
Serial |
728 |
| Permanent link to this record |
