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Author (up) Bedrosian, T.A.; Fonken, L.K.; Nelson, R.J. url  doi
openurl 
  Title Endocrine Effects of Circadian Disruption Type Journal Article
  Year 2015 Publication Annual Review of Physiology Abbreviated Journal Annu Rev Physiol  
  Volume 78 Issue Pages 109-131  
  Keywords Health  
  Abstract Disruption of circadian rhythms, provoked by artificial lighting at night, inconsistent sleep-wake schedules, and transmeridian air travel, is increasingly prevalent in modern society. Desynchrony of biological rhythms from environmental light cycles has dramatic consequences for human health. In particular, disrupting homeostatic oscillations in endocrine tissues and the hormones that these tissues regulate can have cascading effects on physiology and behavior. Accumulating evidence suggests that chronic disruption of circadian organization of endocrine function may lead to metabolic, reproductive, sleep, and mood disorders. This review discusses circadian control of endocrine systems and the consequences of distorting rhythmicity of these systems. Expected final online publication date for the Annual Review of Physiology Volume 78 is February 10, 2016. Please see http://www.annualreviews.org/catalog/pubdates.aspx for revised estimates.  
  Address Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA 92037  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0066-4278 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:26208951 Approved no  
  Call Number LoNNe @ kyba @ Serial 1231  
Permanent link to this record
 

 
Author (up) Bedrosian, T.A.; Nelson, R.J. url  doi
openurl 
  Title Timing of light exposure affects mood and brain circuits Type Journal Article
  Year 2017 Publication Translational Psychiatry Abbreviated Journal Transl Psychiatry  
  Volume 7 Issue 1 Pages e1017  
  Keywords Human Health; Review  
  Abstract Temporal organization of physiology is critical for human health. In the past, humans experienced predictable periods of daily light and dark driven by the solar day, which allowed for entrainment of intrinsic circadian rhythms to the environmental light-dark cycles. Since the adoption of electric light, however, pervasive exposure to nighttime lighting has blurred the boundaries of day and night, making it more difficult to synchronize biological processes. Many systems are under circadian control, including sleep-wake behavior, hormone secretion, cellular function and gene expression. Circadian disruption by nighttime light perturbs those processes and is associated with increasing incidence of certain cancers, metabolic dysfunction and mood disorders. This review focuses on the role of artificial light at night in mood regulation, including mechanisms through which aberrant light exposure affects the brain. Converging evidence suggests that circadian disruption alters the function of brain regions involved in emotion and mood regulation. This occurs through direct neural input from the clock or indirect effects, including altered neuroplasticity, neurotransmission and clock gene expression. Recently, the aberrant light exposure has been recognized for its health effects. This review summarizes the evidence linking aberrant light exposure to mood.  
  Address Department of Neuroscience, Behavioral Neuroendocrinology Group, The Ohio State University Wexner Medical Center, Columbus, OH, USA  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 2158-3188 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:28140399; PMCID:PMC5299389 Approved no  
  Call Number GFZ @ kyba @ Serial 2446  
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Author (up) Behn, C.; De Gregorio, N. url  doi
openurl 
  Title Melatonin Relations with Energy Metabolism as Possibly Involved in Fatal Mountain Road Traffic Accidents Type Journal Article
  Year 2020 Publication International Journal of Molecular Sciences Abbreviated Journal Int J Mol Sci  
  Volume 21 Issue 6 Pages  
  Keywords Review; Human Health; dysrhythmia; melatonin; mountain road death  
  Abstract Previous results evidenced acute exposure to high altitude (HA) weakening the relation between daily melatonin cycle and the respiratory quotient. This review deals with the threat extreme environments pose on body time order, particularly concerning energy metabolism. Working at HA, at poles, or in space challenge our ancestral inborn body timing system. This conflict may also mark many aspects of our current lifestyle, involving shift work, rapid time zone crossing, and even prolonged office work in closed buildings. Misalignments between external and internal rhythms, in the short term, traduce into risk of mental and physical performance shortfalls, mood changes, quarrels, drug and alcohol abuse, failure to accomplish with the mission and, finally, high rates of fatal accidents. Relations of melatonin with energy metabolism being altered under a condition of hypoxia focused our attention on interactions of the indoleamine with redox state, as well as, with autonomic regulations. Individual tolerance/susceptibility to such interactions may hint at adequately dealing with body timing disorders under extreme conditions.  
  Address Laboratory of Extreme Environments, Department of Physiology and Biophysics, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago 8380453, Chile  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1422-0067 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:32235717; PMCID:PMC7139848 Approved no  
  Call Number GFZ @ kyba @ Serial 3016  
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Author (up) Benedetto, M.M.; Contin, M.A. url  doi
openurl 
  Title Oxidative Stress in Retinal Degeneration Promoted by Constant LED Light Type Journal Article
  Year 2019 Publication Frontiers in Cellular Neuroscience Abbreviated Journal Front. Cell. Neurosci.  
  Volume 13 Issue Pages  
  Keywords Vision; Human Health  
  Abstract Light pollution by artificial light, might accelerate retinal diseases and circadian asynchrony. The excess of light exposure is a growing problem in societies, so studies on the consequences of long-term exposure to low levels of light are needed to determine the effects on vision. The possibility to understand the molecular mechanisms of light damage will contribute to the knowledge about visual disorders related to defects in the phototransduction. Several animal models have been used to study retinal degeneration (RD) by light; however, some important aspects remain to be established. Previously, we demonstrated that cool white treatment of 200 lux light-emitting diode (LED) induces retinal transformation with rods and cones cell death and significant changes in opsin expression in the inner nuclear layer (INL) and ganglion cell layer (GCL). Therefore, to further develop describing the molecular pathways of RD, we have examined here the oxidative stress and the fatty acid composition in rat retinas maintained at constant light. We demonstrated the existence of oxidative reactions after 5 days in outer nuclear layer (ONL), corresponding to classical photoreceptors; catalase (CAT) enzyme activity did not show significant differences in all times studied and the fatty acid study showed that docosahexaenoic acid decreased after 4 days. Remarkably, the docosahexaenoic acid diminution showed a correlation with the rise in stearic acid indicating a possible association between them. We assumed that the reduction in docosahexaenoic acid may be affected by the oxidative stress in photoreceptors outer segment which in turn affects the stearic acid composition with consequences in the membrane properties. All these miss-regulation affects the photoreceptor survival through unknown mechanisms involved. We consider that oxidative stress might be one of the pathways implicated in RD promoted by light.  
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  Series Volume Series Issue Edition  
  ISSN 1662-5102 ISBN Medium  
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  Notes Approved no  
  Call Number GFZ @ kyba @ Serial 2333  
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Author (up) Benke, K.E.; Benke, K.K.; Dimitriadis, C. url  openurl
  Title Spectral content of artificial lighting and effects on health. Type Journal Article
  Year 2011 Publication Journal of the Australasian College of Nutritional and Environmental Medicine Abbreviated Journal  
  Volume 30 Issue 3 Pages 13-15  
  Keywords Human Health  
  Abstract There is an increasing body of evidence indicating possible health effects from prolonged exposure to artificial lighting after dark. Both compact fluorescent lights and light emitting diode lamps have a greater proportion of blue light in the emission spectrum than the older incandescent light sources. Exposure to the blue light component at night has been the subject of ongoing research, with a number of published studies linking blue light content to the disruption of the internal body clock, suppression of melatonin production and various ocular effects. Aside from short-term discomfort, possible health effects include long-term chronic illnesses, including cancer, cardiovascular disease and diabetes. A brief review of recent research is provided, salient health issues are noted and discussed, and some examples of exposure minimisation strategies are suggested.  
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  Notes Approved no  
  Call Number LoNNe @ christopher.kyba @ Serial 520  
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