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Author Bedrosian, T.A. (ed) pdf  url
openurl 
  Title Circadian Disruption by Light at Night: Implications for Mood Type Book Whole
  Year 2013 Publication (up) Abbreviated Journal  
  Volume Issue Pages  
  Keywords circadian disruption; sleep; light at night; melanopsin; mood; mental health; Mood Disorders; epigenetics; red light  
  Abstract Life on Earth has adapted to a consistent 24-h solar cycle. Circadian rhythms in physiology and behavior remain synchronized to the environment using light as the most potent entraining cue. During the past century, however, the widespread adoption of electric light has led to `round-the-clock’ societies. Instead of aligning with the environment, individuals follow artificial and often erratic light cycles created by social and work schedules. In particular, exposure to artificial light at night (LAN), termed “light pollution”, has become pervasive over the past 100 years. Virtually every individual living in the U.S. and Europe experiences this aberrant light exposure, and moreover about 20% of the population performs shift work. LAN may disrupt physiological timekeeping, leading to dysregulation of internal processes and misalignment between behavior and the environment. Recent evidence suggests that individuals exposed to excessive LAN, such as night shift workers, have increased risk for depressive disorders, but the biological mechanism remains unspecified. In mammals, intrinsically photosensitive retinal ganglion cells (ipRGCs) project light information to (1) the suprachiasmatic nucleus (SCN) in the hypothalamus, regulating circadian rhythms, and (2) to limbic regions, putatively regulating mood. Thus, LAN has the potential to affect both circadian timekeeping and mood. In this dissertation, I present evidence from rodent studies supporting the novel hypothesis that night-time exposure to light disrupts circadian organization and contributes to depressed mood. First, I consider the physiological and behavioral consequences associated with unnatural exposure to LAN. The effects of LAN on circadian output are considered in terms of locomotor activity, the diurnal cortisol rhythm, and diurnal clock protein expression in the brain in Chapter 2. The influence of LAN on behavior and brain plasticity is discussed, with particular focus on depressive-like behavior (Chapter 3) and effects of SSRI treatment (Chapter 4). Effects of LAN on structural plasticity and gene expression in the brain are described, with emphasis on potential correlates of the depressive-like behavior observed under LAN in Chapter 5. Given the prevalence of LAN exposure and its importance, strategies for reversing the effects are offered. Specifically, eliminating LAN quickly reverses behavioral and physiological effects of exposure as described in Chapter 5. In Chapter 6 I report that administration of a pharmacological cytokine inhibitor prevents depressive-like behaviors in LAN, implicating brain inflammation in the behavioral effect. Finally, I demonstrate in Chapter 7 that exposure to red wavelength LAN reduces the effects on brain and behavior, suggesting that LAN acts through specific retinal pathways involving melanopsin. Taken together, these studies demonstrate the consequences of LAN, but also outline potential avenues for prevention or intervention.  
  Address Department of Neuroscience and The Institute for Behavioral Medicine Research The Ohio State University  
  Corporate Author Thesis Ph.D. thesis  
  Publisher Place of Publication Editor Bedrosian, T.A.  
  Language Summary Language Original Title  
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  Area Expedition Conference  
  Notes Approved no  
  Call Number IDA @ john @ Serial 323  
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Author Provencio, I.; Rodriguez, I.R.; Jiang, G.; Hayes, W.P.; Moreira, E.F.; Rollag, M.D. url  openurl
  Title A Novel Human Opsin in the Inner Retina. Type Journal Article
  Year 2000 Publication (up) Abbreviated Journal  
  Volume 20 Issue 2 Pages 600-605  
  Keywords Human Health  
  Abstract Here we report the identification of a novel human opsin, melanopsin, that is expressed in cells of the mammalian inner retina. The human melanopsin gene consists of 10 exons and is mapped to chromosome 10q22. This chromosomal localization and gene structure differs significantly from that of other human opsins that typically have four to seven exons. A survey of 26 anatomical sites indicates that, in humans, melanopsin is expressed only in the eye. In situ hybridization histochemistry shows that melanopsin expression is restricted to cells within the ganglion and amacrine cell layers of the primate and murine retinas. Notably, expression is not observed in retinal photoreceptor cells, the opsin-containing cells of the outer retina that initiate vision. The unique inner retinal localization of melanopsin suggests that it is not involved in image formation but rather may mediate nonvisual photoreceptive tasks, such as the regulation of circadian rhythms and the acute suppression of pineal melatonin. The anatomical distribution of melanopsin-positive retinal cells is similar to the pattern of cells known to project from the retina to the suprachiasmatic nuclei of the hypothalamus, a primary circadian pacemaker.  
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  Notes Approved no  
  Call Number LoNNe @ christopher.kyba @ Serial 530  
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Author WHO openurl 
  Title Shiftwork, in IARC Monographs on the Evaluation of Carcinogenic Risks to Humans Type Journal Article
  Year 2010 Publication (up) Abbreviated Journal  
  Volume Issue Pages 562-764  
  Keywords Human Health  
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  Notes Approved no  
  Call Number LoNNe @ kagoburian @ Serial 833  
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Author Roenneberg, T. url  openurl
  Title Wie wir ticken. Die Bedeutung der inneren Uhr für unser Leben Type Journal Article
  Year 2010 Publication (up) Abbreviated Journal  
  Volume Issue Pages 240  
  Keywords Human Health  
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  Notes Approved no  
  Call Number LoNNe @ kagoburian @ Serial 844  
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Author Zulley, J.; Knab, B. url  openurl
  Title Zulley, Jürgen und Knab, Barbara (2009): Unsere Innere Uhr. Natürliche Rhythmen nutzen und derNon-Stop-Belastung entgehen Type Journal Article
  Year 2009 Publication (up) Abbreviated Journal  
  Volume Issue Pages  
  Keywords Human Health  
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  Area Expedition Conference  
  Notes Approved no  
  Call Number LoNNe @ kagoburian @ Serial 845  
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