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Author Pan, Y.-R.; Song, J.-Y.; Fan, B.; Wang, Y.; Che, L.; Zhang, S.-M.; Chang, Y.-X.; He, C.; Li, G.-Y. url  doi
openurl 
  Title mTOR may interact with PARP-1 to regulate visible light-induced parthanatos in photoreceptors Type Journal Article
  Year 2020 Publication Cell Communication and Signaling : CCS Abbreviated Journal Cell Commun Signal  
  Volume 18 Issue 1 Pages 27  
  Keywords Health; Aif; Parp-1; Parthanatos; Retinal neuroprotection; Sirt1; mTOR  
  Abstract BACKGROUND: Excessive light exposure is a detrimental environmental factor that plays a critical role in the pathogenesis of retinal degeneration. However, the mechanism of light-induced death of retina/photoreceptor cells remains unclear. The mammalian/mechanistic target of rapamycin (mTOR) and Poly (ADP-ribose) polymerase-1 (PARP-1) have become the primary targets for treating many neurodegenerative disorders. The aim of this study was to elucidate the mechanisms underlying light-induced photoreceptor cell death and whether the neuroprotective effects of mTOR and PARP-1 inhibition against death are mediated through apoptosis-inducing factor (AIF). METHODS: Propidium iodide (PI)/Hoechst staining, lentiviral-mediated short hairpin RNA (shRNA), Western blot analysis, cellular fraction separation, plasmid transient transfection, laser confocal microscopy, a mice model, electroretinography (ERG), and hematoxylin-eosin (H & E) staining were employed to explore the mechanisms by which rapamycin/3-Aminobenzamide (3AB) exert neuroprotective effects of mTOR/PARP-1 inhibition in light-injured retinas. RESULTS: A parthanatos-like death mechanism was evaluated in light-injured 661 W cells that are an immortalized photoreceptor-like cell line that exhibit cellular and biochemical feature characteristics of cone photoreceptor cells. The death process featured over-activation of PARP-1 and AIF nuclear translocation. Either PARP-1 or AIF knockdown played a significantly protective role for light-damaged photoreceptors. More importantly, crosstalk was observed between mTOR and PARP-1 signaling and mTOR could have regulated parthanatos via the intermediate factor sirtuin 1 (SIRT1). The parthanatos-like injury was also verified in vivo, wherein either PARP-1 or mTOR inhibition provided significant neuroprotection against light-induced injury, which is evinced by both structural and functional retinal analysis. Overall, these results elucidate the mTOR-regulated parthanatos death mechanism in light-injured photoreceptors/retinas and may facilitate the development of novel neuroprotective therapies for retinal degeneration diseases. CONCLUSIONS: Our results demonstrate that inhibition of the mTOR/PARP-1 axis exerts protective effects on photoreceptors against visible-light-induced parthanatos. These protective effects are conducted by regulating the downstream factors of AIF, while mTOR possibly interacts with PARP-1 via SIRT1 to regulate parthanatos. Video Abstract Schematic diagram of mTOR interacting with PARP-1 to regulate visible light-induced parthanatos. Increased ROS caused by light exposure penetrates the nuclear membrane and causes nuclear DNA strand breaks. PARP-1 detects DNA breaks and synthesizes PAR polymers to initiate the DNA repair system that consumes a large amount of cellular NAD+. Over-production of PAR polymers prompts the release of AIF from the mitochondria and translocation to the nucleus, which leads to parthanatos. Activated mTOR may interact with PARP-1 via SIRT1 to regulate visible light-induced parthanatos.  
  Address Department of Ophthalmology, Second Hospital of JiLin University, No.218 Zi-Qiang St, ChangChun, 130041, China. liguangyu@aliyun.com  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1478-811X ISBN Medium  
  Area Expedition Conference  
  Notes PMID:32066462 Approved no  
  Call Number GFZ @ kyba @ Serial (down) 2830  
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Author Ritonja, J.; McIsaac, M.A.; Sanders, E.; Kyba, C.C.M.; Grundy, A.; Cordina-Duverger, E.; Spinelli, J.J.; Aronson, K.J. url  doi
openurl 
  Title Outdoor light at night at residences and breast cancer risk in Canada Type Journal Article
  Year 2020 Publication European Journal of Epidemiology Abbreviated Journal Eur J Epidemiol  
  Volume in press Issue Pages  
  Keywords Human Health; Breast cancer; Case-control study; Circadian disruption; Light at night; Night work; Women's health  
  Abstract Experimental and epidemiologic studies suggest that light at night (LAN) exposure disrupts circadian rhythm, and this disruption may increase breast cancer risk. We investigated the potential association between residential outdoor LAN and breast cancer risk. A population-based case-control study was conducted in Vancouver, British Columbia and Kingston, Ontario, Canada with incident breast cancer cases, and controls frequency matched by age in the same region. This analysis was restricted to 844 cases and 905 controls who provided lifetime residential histories. Using time-weighted average duration at each home 5-20 years prior to study entry, two measures of cumulative average outdoor LAN were calculated using two satellite data sources. Logistic regression was used to estimate the relationship between outdoor LAN and breast cancer risk, considering interactions for menopausal status and night shift work. We found no association between residential outdoor LAN and breast cancer for either measure of LAN [OR comparing highest vs. lowest tertile (DNB) = 0.95, 95% CI 0.70-1.27]. We also found no association when considering interactions for menopausal status and past/current night work status. These findings were robust to changes to years of residential data considered, residential mobility, and longer exposure windows. Our findings are consistent with studies reporting that outdoor LAN has a small effect or no effect on breast cancer risk.  
  Address Division of Cancer Care and Epidemiology, Cancer Research Institute, Queen's University, Kingston, ON, Canada. aronson@queensu.ca  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0393-2990 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:32026169 Approved no  
  Call Number GFZ @ kyba @ Serial (down) 2826  
Permanent link to this record
 

 
Author Sletten, T.L.; Cappuccio, F.P.; Davidson, A.J.; Van Cauter, E.; Rajaratnam, S.M.W.; Scheer, F.A.J.L. url  doi
openurl 
  Title Health consequences of circadian disruption Type Journal Article
  Year 2020 Publication Sleep Abbreviated Journal Sleep  
  Volume 43 Issue 1 Pages  
  Keywords Human Health; Circadian Rhythm; Chronobiology; Sleep; Review  
  Abstract The circadian system is key for optimal functioning by maintaining synchrony between internal circadian rhythms, behaviors, and external cues. Many clinicians are not fully aware, however, of the far-reaching implications of the circadian system for human health. Clinical attention to circadian rhythms has largely focused on sleep disturbances. The impact of the circadian system on health is, however, much broader. Clinical diagnoses are often based on single time point assessments during the day, ignoring circadian influences on physiology. Even when time is considered, using (external) clock time ignores the large interindividual differences in internal timing.  
  Address Division of Sleep Medicine, Harvard Medical School, Boston, MA  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0161-8105 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:31930347 Approved no  
  Call Number IDA @ john @ Serial (down) 2822  
Permanent link to this record
 

 
Author Tossa, P.; Souques, M. url  doi
openurl 
  Title Effects of artificial light at night and light pollution on human circadian rhythms Type Journal Article
  Year 2019 Publication Environnement Risques Santé Abbreviated Journal  
  Volume 18 Issue 6 Pages 477-487  
  Keywords Reveiw; Human Health  
  Abstract Artificial light is a tangible manifestation of economic and social development, as well as a response to certain needs, especially comfort and civil and road safety. However, this use has been so associated with technological progress that its invasion of daily life has been almost imperceptible. With the recent increase in night lighting (11 million light points in 2016 according to the French Agency for the Environment and Energy Management) and the production of new lamp technologies (in particular light-emitting diodes or LEDs), societal concerns have emerged and are growing. These concerns include light pollution and the impact of blue light on human health and the environment. The scientific community has also taken up the subject, publishing in recent years a large and ever-increasing number of articles on the effects of artificial light at night on fauna and flora as well as on human health. In this review, we propose a synthesis of knowledge on human health effects of light based on scientific reports and an update of recent scientific production.

This review updates knowledge of the chronobiological effects of light at night, particularly blue light. We also briefly describe the potential beneficial effects of light on well-being.
 
  Address  
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  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1635-0421 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number GFZ @ kyba @ Serial (down) 2806  
Permanent link to this record
 

 
Author Martinsons, C.; Attia, D.; Behar-Cohen, F.; Carré, S.; Enouf, O.; Falcón, J.; Gronfier, C.; Hicks, D.; Metlaine, A.; Tahkamo, L.; Torriglia, A.; Viénot, F. url  doi
openurl 
  Title Correspondence: An appraisal of the effects on human health and the environment of using light-emitting diodes Type Journal Article
  Year 2019 Publication Lighting Research & Technology Abbreviated Journal Lighting Research & Technology  
  Volume 51 Issue 8 Pages 1275-1276  
  Keywords Commentary; Human Health; Ecology  
  Abstract In May 2019, a collective appraisal report of the effects on human health and the environment of systems using light emitting diodes(LEDs) was published by ANSES, the French Agency for Food, Environmental and Occupational Health and Safety. Here, the experts involved in this work provide anover view of their conclusions and recommendations.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1477-1535 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number GFZ @ kyba @ Serial (down) 2789  
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