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Author Zhu, X.; Guo, X.; Zhang, J.; Liu, J.; Jiang, F. url  doi
openurl 
  Title Phosphor-free, color-mixed, and efficient illuminant: Multi-chip packaged LEDs for optimizing blue light hazard and non-visual biological effects Type Journal Article
  Year 2020 Publication Optics and Lasers in Engineering Abbreviated Journal Optics and Lasers in Engineering  
  Volume 134 Issue Pages 106174  
  Keywords Lighting; Human Health  
  Abstract Currently many evaluation models on the photobiological effects (PBE) of light sources do not consider the influence of age and luminance on the pupil diameter, which affects the light radiation intensity on the human retina. In this study, the pupil diameter is taken into consideration when evaluating the PBE of several light sources. Moreover, the correction factor M is proposed. The blue light hazard (BLH) efficacy and the circadian rhythm (CR) effects of the daylight at dusk, together with three indoor light sources with a correlated color temperature (CCT) of about 3000 K were evaluated by using a corrected evaluation model. The results show that an incandescent lamp is more photobiologically friendly for humans, despite being inefficient. Based on high wall-plug efficiency (WPE) GaN-based yellow (565 nm, 24.3%@20 A/cm2) and green (522 nm, 41.3%@20 A/cm2) LEDs on silicon substrate, incandescent-like spectrum and phosphor-free color-mixed white LEDs (CM-LEDs) with a general color rendering index (CRI) of 94, a CCT of 2866 K, and an efficiency of 131 lm/W were manufactured by mixing blue, cyan, green, yellow and red LEDs. The PBE evaluation results of such CM-LEDs are superior to those of an incandescent lamp. Moreover, blue light free and candlelight-toned LEDs with an efficiency of 120.3 lm/W, a general CRI of 84, a special CRI R9 of 93.3, and a CCT of 1810 K were fabricated by mixing yellow and red LEDs (R&Y-mixed LEDs). The R&Y-mixed LEDs show no blue light weighted quantities and have a weaker influence on the CR shift. They are photobiologically friendly for humans and suitable for nocturnal indoor and outdoor lighting environments.  
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  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0143-8166 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number GFZ @ kyba @ Serial (down) 2983  
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Author An, K.; Zhao, H.; Miao, Y.; Xu, Q.; Li, Y.-F.; Ma, Y.-Q.; Shi, Y.-M.; Shen, J.-W.; Meng, J.-J.; Yao, Y.-G.; Zhang, Z.; Chen, J.-T.; Bao, J.; Zhang, M.; Xue, T. url  doi
openurl 
  Title A circadian rhythm-gated subcortical pathway for nighttime-light-induced depressive-like behaviors in mice Type Journal Article
  Year 2020 Publication Nature Neuroscience Abbreviated Journal Nat Neurosci  
  Volume in press Issue Pages  
  Keywords Human Health  
  Abstract Besides generating vision, light modulates various physiological functions, including mood. While light therapy applied in the daytime is known to have anti-depressive properties, excessive light exposure at night has been reportedly associated with depressive symptoms. The neural mechanisms underlying this day-night difference in the effects of light are unknown. Using a light-at-night (LAN) paradigm in mice, we showed that LAN induced depressive-like behaviors without disturbing the circadian rhythm. This effect was mediated by a neural pathway from retinal melanopsin-expressing ganglion cells to the dorsal perihabenular nucleus (dpHb) to the nucleus accumbens (NAc). Importantly, the dpHb was gated by the circadian rhythm, being more excitable at night than during the day. This indicates that the ipRGC-->dpHb-->NAc pathway preferentially conducts light signals at night, thereby mediating LAN-induced depressive-like behaviors. These findings may be relevant when considering the mental health effects of the prevalent nighttime illumination in the industrial world.  
  Address Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China. xuetian@ustc.edu.cn  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1097-6256 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:32483349 Approved no  
  Call Number GFZ @ kyba @ Serial (down) 2978  
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Author Aarts, M.P.J.; Hartmeyer, S.L.; Morsink, K.; Kort, H.S.M.; de Kort, Y.A.W. url  doi
openurl 
  Title Can Special Light Glasses Reduce Sleepiness and Improve Sleep of Nightshift Workers? A Placebo-Controlled Explorative Field Study Type Journal Article
  Year 2020 Publication Clocks & Sleep Abbreviated Journal Clocks & Sleep  
  Volume 2 Issue 2 Pages 225-245  
  Keywords Human Health  
  Abstract Nightshift workers go against the natural sleep–wake rhythm. Light can shift the circadian clock but can also induce acute alertness. This placebo-controlled exploratory field study examined the effectiveness of light glasses to improve alertness while reducing the sleep complaints of hospital nurses working nightshifts. In a crossover within-subjects design, 23 nurses participated, using treatment glasses and placebo glasses. Sleepiness and sleep parameters were measured. A linear mixed model analysis on sleepiness revealed no significant main effect of the light intervention. An interaction effect was found indicating that under the placebo condition, sleepiness was significantly higher on the first nightshift than on the last night, while under the treatment condition, sleepiness remained stable across nightshift sessions. Sleepiness during the commute home also showed a significant interaction effect, demonstrating that after the first nightshift, driver sleepiness was higher for placebo than for treatment. Subjective sleep quality showed a negative main effect of treatment vs. placebo, particularly after the first nightshift. In retrospect, both types of light glasses were self-rated as effective. The use of light glasses during the nightshift may help to reduce driver sleepiness during the commute home, which is relevant, as all participants drove home by car or (motor) bike.  
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  ISSN 2624-5175 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number GFZ @ kyba @ Serial (down) 2977  
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Author Xiao, Q.; James, P.; Breheny, P.; Jia, P.; Park, Y.; Zhang, D.; Fisher, J.A.; Ward, M.H.; Jones, R.R. url  doi
openurl 
  Title Outdoor light at night and postmenopausal breast cancer risk in the NIH-AARP diet and health study Type Journal Article
  Year 2020 Publication International Journal of Cancer Abbreviated Journal Int J Cancer  
  Volume in press Issue Pages  
  Keywords Human Health; circadian disruption; outdoor light at night; postmenopausal breast cancer; prospective cohort  
  Abstract Circadian disruption may play a role in breast carcinogenesis. Previous studies reported relationships between outdoor light at night (LAN) and the breast cancer risk, but their findings are mixed. There is also a need to examine LAN and breast cancer incidence according to different individual and environmental characteristics to identify subpopulations at greater risk associated with LAN exposure. We studied residential outdoor LAN estimated from satellite imagery at baseline (1996) in relation to postmenopausal breast cancer incidence over ~16 years of follow-up in 186 981 postmenopausal women including 12 318 incident postmenopausal breast cancer cases in the NIH-AARP Diet and Health Study. We used Cox proportional hazards models to estimate hazard ratios (HR) and two-sided 95% confidence intervals (CI) of the relationship between quintiles of LAN and postmenopausal breast cancer risk, overall and by hormone receptor status and cancer stage. We found that when compared to women in the lowest quintile of baseline LAN, those in the highest quintile had a 10% increase in postmenopausal breast cancer risk (HR (95% CI), 1.10 (1.02, 1.18), P-trend, .002). The association appeared to be stronger for estrogen receptor (ER) positive breast cancer (1.12 [1.02, 1.24], .007) than for ER-negative cancer (1.07 [0.85, 1.34], .66). Our findings also suggested that the relationship between LAN and breast cancer risk may differ by individual characteristics, such as smoking, alcohol drinking, sleep duration and BMI, and neighborhood environment. In conclusion, our study suggests that higher outdoor LAN exposure may be a risk factor for postmenopausal breast cancer.  
  Address Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland, USA  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0020-7136 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:32488897 Approved no  
  Call Number GFZ @ kyba @ Serial (down) 2976  
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Author Factors Influencing Quality of Sleep among Critically Ill Patients in Selected Hospitals in Western Kenya url  openurl
  Title Factors Influencing Quality of Sleep among Critically Ill Patients in Selected Hospitals in Western Kenya Type Journal Article
  Year 2018 Publication Journal of Health, Medicine and Nursing Abbreviated Journal  
  Volume 56 Issue Pages  
  Keywords Human Health  
  Abstract Sleep is essential for rest, repair, well-being, and survival of the patient. Sleep quality varies in critically ill patients and is measured by patient's satisfaction of the sleep experience, integrating aspects of sleep initiation, sleep maintenance, quantity of sleep and the refreshment upon awakening. Altered sleep is a common problem experienced by patients in critical care units. This alterations may lead to physiological and psychological dysfunctions that may affect recovery. Critically ill patients frequently experience poor sleep, characterized by frequent disruptions and loss of circadian rhythms. This study investigated factors influencing the quality of sleep among critically ill patients in hospitals in Western Kenya. A cross-sectional descriptive research design was used to examine these factors. A total of 142 patients above 18 years who were admitted to the Intensive Care Unit (ICU) and those transferred from the ICU to the general ward during the study period were conveniently selected for participation in the study. For triangulation, 10 nurses who worked in the ICU also participated in the study. A structured questionnaire was used to collect data from patients while a checklist was used to observe nursing interventions. Descriptive statistical techniques used were frequencies and percentages, while chi-square was used with the p-value set at 0.05 to test the association between factors and quality of sleep. The study results showed that frequent, nursing care activities 96.5% (n=137) noise from ventilator alarms 83.1% (n=118), feeling thirsty 57.7% (n= 82) and pain 52.8% (n=75) were among the major factors influencing the quality of sleep in ICU. A one-way analysis of variance (ANOVA) revealed patient factors significantly associated with quality sleep were age p=.006 and marital status p=.02, environmental factors significantly affecting sleep were presence of light at night with a p <0.0001 and noise from alarms p=.01. Physiological factors included feeling of thirst and hunger (p=0.03). This study recommends optimal use of analgesics and sedatives for pain management, adequate fluid replacement and hydration, noise reduction strategies, including minimizing monitor and ventilator alarms, reducing staff and telephone conversations and use of ear plugs for patients in ICU. Further, nurses should implement clustered procedures to reduce disruption of sleep among critically ill patients.  
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  Area Expedition Conference  
  Notes Approved no  
  Call Number IDA @ intern @ Serial (down) 2974  
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