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Author An, K.; Zhao, H.; Miao, Y.; Xu, Q.; Li, Y.-F.; Ma, Y.-Q.; Shi, Y.-M.; Shen, J.-W.; Meng, J.-J.; Yao, Y.-G.; Zhang, Z.; Chen, J.-T.; Bao, J.; Zhang, M.; Xue, T.
Title A circadian rhythm-gated subcortical pathway for nighttime-light-induced depressive-like behaviors in mice Type Journal Article
Year (down) 2020 Publication Nature Neuroscience Abbreviated Journal Nat Neurosci
Volume in press Issue Pages
Keywords Human Health
Abstract Besides generating vision, light modulates various physiological functions, including mood. While light therapy applied in the daytime is known to have anti-depressive properties, excessive light exposure at night has been reportedly associated with depressive symptoms. The neural mechanisms underlying this day-night difference in the effects of light are unknown. Using a light-at-night (LAN) paradigm in mice, we showed that LAN induced depressive-like behaviors without disturbing the circadian rhythm. This effect was mediated by a neural pathway from retinal melanopsin-expressing ganglion cells to the dorsal perihabenular nucleus (dpHb) to the nucleus accumbens (NAc). Importantly, the dpHb was gated by the circadian rhythm, being more excitable at night than during the day. This indicates that the ipRGC-->dpHb-->NAc pathway preferentially conducts light signals at night, thereby mediating LAN-induced depressive-like behaviors. These findings may be relevant when considering the mental health effects of the prevalent nighttime illumination in the industrial world.
Address Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China. xuetian@ustc.edu.cn
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1097-6256 ISBN Medium
Area Expedition Conference
Notes PMID:32483349 Approved no
Call Number GFZ @ kyba @ Serial 2978
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Author Zhu, X.; Guo, X.; Zhang, J.; Liu, J.; Jiang, F.
Title Phosphor-free, color-mixed, and efficient illuminant: Multi-chip packaged LEDs for optimizing blue light hazard and non-visual biological effects Type Journal Article
Year (down) 2020 Publication Optics and Lasers in Engineering Abbreviated Journal Optics and Lasers in Engineering
Volume 134 Issue Pages 106174
Keywords Lighting; Human Health
Abstract Currently many evaluation models on the photobiological effects (PBE) of light sources do not consider the influence of age and luminance on the pupil diameter, which affects the light radiation intensity on the human retina. In this study, the pupil diameter is taken into consideration when evaluating the PBE of several light sources. Moreover, the correction factor M is proposed. The blue light hazard (BLH) efficacy and the circadian rhythm (CR) effects of the daylight at dusk, together with three indoor light sources with a correlated color temperature (CCT) of about 3000 K were evaluated by using a corrected evaluation model. The results show that an incandescent lamp is more photobiologically friendly for humans, despite being inefficient. Based on high wall-plug efficiency (WPE) GaN-based yellow (565 nm, 24.3%@20 A/cm2) and green (522 nm, 41.3%@20 A/cm2) LEDs on silicon substrate, incandescent-like spectrum and phosphor-free color-mixed white LEDs (CM-LEDs) with a general color rendering index (CRI) of 94, a CCT of 2866 K, and an efficiency of 131 lm/W were manufactured by mixing blue, cyan, green, yellow and red LEDs. The PBE evaluation results of such CM-LEDs are superior to those of an incandescent lamp. Moreover, blue light free and candlelight-toned LEDs with an efficiency of 120.3 lm/W, a general CRI of 84, a special CRI R9 of 93.3, and a CCT of 1810 K were fabricated by mixing yellow and red LEDs (R&Y-mixed LEDs). The R&Y-mixed LEDs show no blue light weighted quantities and have a weaker influence on the CR shift. They are photobiologically friendly for humans and suitable for nocturnal indoor and outdoor lighting environments.
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0143-8166 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number GFZ @ kyba @ Serial 2983
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Author Bagci, S.; Sabir, H.; Muller, A.; Reiter, R.J.
Title Effects of altered photoperiod due to COVID-19 lockdown on pregnant women and their fetuses Type Journal Article
Year (down) 2020 Publication Chronobiology International Abbreviated Journal Chronobiol Int
Volume in press Issue Pages in press
Keywords Human Health; Covid-19; circadian disruption; fetus; lockdown; melatonin; pregnant Women
Abstract Maternal circadian rhythms provide highly important input into the entrainment and programming of fetal and newborn circadian rhythms. The light-dark cycle is an important regulator of the internal biological clock. Even though pregnant women spend a greater part of the day at home during the latter stages of pregnancy, natural light exposure is crucial for the fetus. The current recommended COVID-19 lockdown might dramatically alter normal environmental lighting conditions of pregnant women, resulting in exposure to extremely low levels of natural daylight and high-intensity artificial light sources during both day and night. This article summarizes the potential effects on pregnant woman and their fetuses due to prolonged exposure to altered photoperiod and as consequence altered circadian system, known as chronodisruption, that may result from the COVID-19 lockdown.
Address Department of Cell Systems and Anatomy, UT Health San Antonio , San Antonio, Texas, USA
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0742-0528 ISBN Medium
Area Expedition Conference
Notes PMID:32519912 Approved no
Call Number GFZ @ kyba @ Serial 3007
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Author Moore-Ede, M.; Heitmann, A.; Guttkuhn, R.
Title Circadian Potency Spectrum with Extended Exposure to Polychromatic White LED Light under Workplace Conditions Type Journal Article
Year (down) 2020 Publication Journal of Biological Rhythms Abbreviated Journal J Biol Rhythms
Volume in press Issue Pages in press
Keywords Human Health; circadian; human; light spectrum; melatonin; spectral sensitivity
Abstract Electric light has enabled humans to conquer the night, but light exposure at night can disrupt the circadian timing system and is associated with a diverse range of health disorders. To provide adequate lighting for visual tasks without disrupting the human circadian timing system, a precise definition of circadian spectral sensitivity is required. Prior attempts to define the circadian spectral sensitivity curve have used short (</=90-min) monochromatic light exposures in dark-adapted human subjects or in vitro dark-adapted isolated retina or melanopsin. Several lines of evidence suggest that these dark-adapted circadian spectral sensitivity curves, in addition to 430- to 499-nm (blue) wavelength sensitivity, may include transient 400- to 429-nm (violet) and 500- to 560-nm (green) components mediated by cone- and rod-originated extrinsic inputs to intrinsically photosensitive retinal ganglion cells (ipRGCs), which decay over the first 2 h of extended light exposure. To test the hypothesis that the human circadian spectral sensitivity in light-adapted conditions may have a narrower, predominantly blue, sensitivity, we used 12-h continuous exposures of light-adapted healthy human subjects to 6 polychromatic white light-emitting diode (LED) light sources with diverse spectral power distributions at recommended workplace levels of illumination (540 lux) to determine their effect on the area under curve of the overnight (2000-0800 h) salivary melatonin. We derived a narrow steady-state human Circadian Potency spectral sensitivity curve with a peak at 477 nm and a full-width half-maximum of 438 to 493 nm. This light-adapted Circadian Potency spectral sensitivity permits the development of spectrally engineered LED light sources to minimize circadian disruption and address the health risks of light exposure at night in our 24/7 society, by alternating between daytime circadian stimulatory white light spectra and nocturnal circadian protective white light spectra.
Address Data Analytics Department, Circadian Technologies, Inc., Stoneham, Massachusetts
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0748-7304 ISBN Medium
Area Expedition Conference
Notes PMID:32539484 Approved no
Call Number GFZ @ kyba @ Serial 3010
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Author LeGates, T.A.; Kvarta, M.D.
Title Illuminating a path from light to depression Type Journal Article
Year (down) 2020 Publication Nature Neuroscience Abbreviated Journal Nat Neurosci
Volume in press Issue Pages
Keywords Commentary; Animals; Human Health
Abstract Our light environment can strongly influence our mental health. Kai An and colleagues dissect the neuronal circuit mediating depression-related behaviors induced by mistimed light input in mice, implicating the nucleus accumbens as the downstream target of the neural pathway between intrinsically photosensitive retinal ganglion cells and the perihabenular nucleus.
Address Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1097-6256 ISBN Medium
Area Expedition Conference
Notes PMID:32555525 Approved no
Call Number GFZ @ kyba @ Serial 3015
Permanent link to this record