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Author Watson, L.A.; Phillips, A.J.K.; Hosken, I.T.; McGlashan, E.M.; Anderson, C.; Lack, L.C.; Lockley, S.W.; Rajaratnam, S.M.W.; Cain, S.W. url  doi
openurl 
  Title Increased sensitivity of the circadian system to light in delayed sleep-wake phase disorder Type Journal Article
  Year 2018 Publication The Journal of Physiology Abbreviated Journal J Physiol  
  Volume in press Issue Pages  
  Keywords Human Health  
  Abstract KEY POINTS: This is the first study to demonstrate an altered circadian phase shifting response in a circadian rhythm sleep disorder. Patients with Delayed Sleep-Wake Phase Disorder (DSWPD) demonstrate greater sensitivity of the circadian system to the phase delaying effects of light. Increased circadian sensitivity to light is associated with later circadian timing within both control and DSWPD groups. DSWPD patients had a greater sustained pupil response after light exposure. Treatments for DSWPD should consider sensitivity of the circadian system to light as a potential underlying vulnerability, making patients susceptible to relapse. ABSTRACT: Patients with Delayed Sleep-Wake Phase Disorder (DSWPD) exhibit delayed sleep-wake behavior relative to desired bedtime, often leading to chronic sleep restriction and daytime dysfunction. The majority of DSWPD patients also display delayed circadian timing in the melatonin rhythm. Hypersensitivity of the circadian system to phase delaying light is a plausible physiological basis for DSWPD vulnerability. We compared the phase shifting response to a 6.5-h light exposure ( approximately 150 lux) between male patients with diagnosed DSWPD (n = 10; aged 22.4 +/- 3.3 years) and male healthy controls (n = 11; aged 22.4 +/- 2.4 years). Salivary dim light melatonin onset (DLMO) was measured under controlled conditions in dim light (<3 lux) before and after light exposure. Correcting for the circadian time of the light exposure, DSWPD patients exhibited 31.5% greater phase delay shifts than healthy controls. In both groups, a later initial phase of the melatonin rhythm was associated with greater magnitude of phase shifts, indicating that increased circadian sensitivity to light may be a factor that contributes to delayed phase, even in non-clinical groups. DSWPD patients also had reduced pupil size following the light exposure, and showed a trend towards increased melatonin suppression during light exposure. These findings indicate that, for patients with DSWPD, assessment of light sensitivity may be an important factor that can inform behavioral therapy, including minimization of exposure to phase-delaying night-time light. This article is protected by copyright. All rights reserved.  
  Address Monash Institute of Cognitive and Clinical Neurosciences, School of Psychological Sciences, Monash University, Melbourne, Victoria, Australia  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0022-3751 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:30281150 Approved no  
  Call Number (up) GFZ @ kyba @ Serial 2026  
Permanent link to this record
 

 
Author Yates, J. url  doi
openurl 
  Title Perspective: The Long-Term Effects of Light Exposure on Establishment of Newborn Circadian Rhythm Type Journal Article
  Year 2018 Publication Journal of Clinical Sleep Medicine Abbreviated Journal Jcsm  
  Volume 14 Issue 10 Pages 1829-1830  
  Keywords Commentary; Human Health  
  Abstract Development of newborns continues postnatally. Evidence has accumulated on the early life programming effects of light exposure on the maturing visual axis and the developing circadian rhythm. Consideration of the effects of light at night and insufficient light during the day should occur when giving anticipatory guidance in the care of newborn infants. Long-term health consequences of light imprinting may occur with inappropriate light-dark environments during the newborn period.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1550-9389 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number (up) GFZ @ kyba @ Serial 2032  
Permanent link to this record
 

 
Author Stevens, R.G. url  doi
openurl 
  Title Comment on 'Domestic light at night and breast cancer risk: a prospective analysis of 105 000 UK women in the Generations Study' Type Journal Article
  Year 2018 Publication British Journal of Cancer Abbreviated Journal Br J Cancer  
  Volume in press Issue Pages  
  Keywords Commentary; Human Health  
  Abstract  
  Address University of Connecticut, School of Medicine, 263 Farmington Avenue, Farmington, CT, 06032, USA. bugs@uchc.edu  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0007-0920 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:30283145 Approved no  
  Call Number (up) GFZ @ kyba @ Serial 2035  
Permanent link to this record
 

 
Author Wurtman, R.J. url  doi
openurl 
  Title The Pineal and Endocrine Function Type Journal Article
  Year 1969 Publication Hospital Practice Abbreviated Journal Hospital Practice  
  Volume 4 Issue 1 Pages 32-37  
  Keywords Human Health  
  Abstract Recognition that levels of hormonal secretion vary markedly from day to night has triggered intensive investigation into the influence of environmental light upon endocrine function. These studies have pointed to the pineal gland as a major mediator of a wide variety of hormonal responses involving the gonads, thyroid, and pituitary, and the hypothalamus and other regions of the brain.  
  Address Human Health  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 2154-8331 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number (up) GFZ @ kyba @ Serial 2037  
Permanent link to this record
 

 
Author Kozaki, T.; Hidaka, Y.; Takakura, J.-Y.; Kusano, Y. url  doi
openurl 
  Title Suppression of salivary melatonin secretion under 100-Hz flickering and non-flickering blue light Type Journal Article
  Year 2018 Publication Journal of Physiological Anthropology Abbreviated Journal J Physiol Anthropol  
  Volume 37 Issue 1 Pages 23  
  Keywords Human Health  
  Abstract BACKGROUND: Bright light at night is known to suppress melatonin secretion. Novel photoreceptors named intrinsically photosensitive retinal ganglion cells (ipRGCs) are mainly responsible for projecting dark/bright information to the suprachiasmatic nucleus and thus regulating the circadian system. However, it has been shown that the amplitude of the electroretinogram of ipRGCs is considerably lower under flickering light at 100 Hz than at 1-5 Hz, suggesting that flickering light may also affect the circadian system. Therefore, in this study, we evaluated light-induced melatonin suppression under flickering and non-flickering light. METHODS: Twelve male participants between the ages of 20 and 23 years (mean +/- S.D. = 21.6 +/- 1.5 years) were exposed to three light conditions (dim, 100-Hz flickering, and non-flickering blue light) from 1:00 A.M. to 2:30 A.M., and saliva samples were obtained just before 1:00 A.M. and at 1:15, 1:30, 2:00, and 2:30 A.M. RESULTS: A repeated measures t test with Bonferroni correction showed that at 1:15 A.M., melatonin concentrations were significantly lower following exposure to non-flickering light compared with dim light, whereas there was no significant difference between the dim and 100-Hz flickering light conditions. By contrast, after 1:30 A.M., the mean melatonin concentrations were significantly lower under both 100-Hz flickering and non-flickering light than under dim light. CONCLUSION: Although melatonin suppression rate tended to be lower under 100-Hz flickering light than under non-flickering light at the initial 15 min of the light exposure, the present study suggests that 100-Hz flickering light may have the same impact on melatonin secretion as non-flickering light.  
  Address Department of Health and Nutrition Sciences, Nishikyushu University, Kanzaki, Japan  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1880-6791 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:30340620 Approved no  
  Call Number (up) GFZ @ kyba @ Serial 2039  
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