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Author Brainard, G.C.; Lewy, A.J.; Menaker, M.; Fredrickson, R.H.; Miller, L.S.; Weleber, R.G.; Cassone, V.; Hudson, D.
Title Effect of Light Wavelength on the Suppression of Nocturnal Plasma Melatonin in Normal Volunteersa Type Journal Article
Year 1985 Publication Annals of the New York Academy of Sciences Abbreviated Journal
Volume 453 Issue 1 Pages 376-378
Keywords Human Health
Abstract
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0077-8923 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number LoNNe @ kagoburian @ Serial 723
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Author Brainard, G.C.; Rollag, M.D.; Hanifin, J.P.
Title Photic Regulation of Melatonin in Humans: Ocular and Neural Signal Transduction Type Journal Article
Year 1997 Publication Journal of Biological Rhythms Abbreviated Journal Journal of Biological Rhythms
Volume 12 Issue 6 Pages 537-546
Keywords Human Health; eye; lens; light; melatonin suppression; photoreceptor; pineal gland; pupil
Abstract
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0748-7304 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number LoNNe @ schroer @ Serial 583
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Author Brainard, G.C.; Sliney, D.; Hanifin, J.P.; Glickman, G.; Byrne, B.; Greeson, J.M.; Jasser, S.; Gerner, E.; Rollag, M.D.
Title Sensitivity of the human circadian system to short-wavelength (420-nm) light Type Journal Article
Year 2008 Publication Journal of Biological Rhythms Abbreviated Journal J Biol Rhythms
Volume 23 Issue 5 Pages 379-386
Keywords Human Health; Adult; Circadian Rhythm/*radiation effects; Female; Humans; *Light; Male; Melatonin/metabolism; Models, Biological; Neurosecretory Systems; Photons; Pineal Gland/metabolism; Retinal Ganglion Cells/*metabolism; Vision, Ocular
Abstract The circadian and neurobehavioral effects of light are primarily mediated by a retinal ganglion cell photoreceptor in the mammalian eye containing the photopigment melanopsin. Nine action spectrum studies using rodents, monkeys, and humans for these responses indicate peak sensitivities in the blue region of the visible spectrum ranging from 459 to 484 nm, with some disagreement in short-wavelength sensitivity of the spectrum. The aim of this work was to quantify the sensitivity of human volunteers to monochromatic 420-nm light for plasma melatonin suppression. Adult female (n=14) and male (n=12) subjects participated in 2 studies, each employing a within-subjects design. In a fluence-response study, subjects (n=8) were tested with 8 light irradiances at 420 nm ranging over a 4-log unit photon density range of 10(10) to 10(14) photons/cm(2)/sec and 1 dark exposure control night. In the other study, subjects (n=18) completed an experiment comparing melatonin suppression with equal photon doses (1.21 x 10(13) photons/cm(2)/sec) of 420 nm and 460 nm monochromatic light and a dark exposure control night. The first study demonstrated a clear fluence-response relationship between 420-nm light and melatonin suppression (p<0.001) with a half-saturation constant of 2.74 x 10(11) photons/cm(2)/sec. The second study showed that 460-nm light is significantly stronger than 420-nm light for suppressing melatonin (p<0.04). Together, the results clarify the visible short-wavelength sensitivity of the human melatonin suppression action spectrum. This basic physiological finding may be useful for optimizing lighting for therapeutic and other applications.
Address Department of Neurology, Thomas Jefferson University, Philadelphia, PA 19107, USA. george.brainard@jefferson.edu
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0748-7304 ISBN Medium
Area Expedition Conference
Notes PMID:18838601 Approved no
Call Number LoNNe @ kagoburian @ Serial 724
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Author Bray, M.S.; Young, M.E.
Title Chronobiological Effects on Obesity Type Journal Article
Year 2012 Publication Current Obesity Reports Abbreviated Journal Curr Obes Rep
Volume 1 Issue 1 Pages 9-15
Keywords Human Health; Chronobiological effects; Circadian; Gene; Molecular clock; Obesity; Rhythm; Shift work; Sleep; Transcription
Abstract The development of obesity is the consequence of a multitude of complex interactions between both genetic and environmental factors. It has been suggested that the dramatic increase in the prevalence of obesity over the past 30 years has been the result of environmental changes that have enabled the full realization of genetic susceptibility present in the population. Among the many environmental alterations that have occurred in our recent history is the ever-increasing dyssynchrony between natural cycles of light/dark and altered patterns of sleep/wake and eating behavior associated with our “24-hour” lifestyle. An extensive research literature has established clear links between increased risk for obesity and both sleep deprivation and shift work, and our understanding of the consequences of such dyssynchrony at the molecular level is beginning to emerge. Studies linking alterations in cellular circadian clocks to metabolic dysfunction point to the increasing importance of chronobiology in obesity etiology.
Address Departments of Epidemiology and Genetics, University of Alabama at Birmingham, Birmingham, AL
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 2162-4968 ISBN Medium
Area Expedition Conference
Notes PMID:23682347; PMCID:PMC3653336 Approved no
Call Number LoNNe @ christopher.kyba @ Serial 510
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Author Bray, M.S.; Young, M.E.
Title Chronobiological Effects on Obesity Type Journal Article
Year 2012 Publication Current Obesity Reports Abbreviated Journal Curr Obes Rep
Volume 1 Issue 1 Pages 9-15
Keywords Human Health; Chronobiological effects; Circadian; Gene; Molecular clock; Obesity; Rhythm; Shift work; Sleep; Transcription
Abstract The development of obesity is the consequence of a multitude of complex interactions between both genetic and environmental factors. It has been suggested that the dramatic increase in the prevalence of obesity over the past 30 years has been the result of environmental changes that have enabled the full realization of genetic susceptibility present in the population. Among the many environmental alterations that have occurred in our recent history is the ever-increasing dyssynchrony between natural cycles of light/dark and altered patterns of sleep/wake and eating behavior associated with our “24-hour” lifestyle. An extensive research literature has established clear links between increased risk for obesity and both sleep deprivation and shift work, and our understanding of the consequences of such dyssynchrony at the molecular level is beginning to emerge. Studies linking alterations in cellular circadian clocks to metabolic dysfunction point to the increasing importance of chronobiology in obesity etiology.
Address Departments of Epidemiology and Genetics, University of Alabama at Birmingham, Birmingham, AL
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 2162-4968 ISBN Medium
Area Expedition Conference
Notes PMID:23682347; PMCID:PMC3653336 Approved no
Call Number LoNNe @ kagoburian @ Serial 725
Permanent link to this record