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Author Alaimo, A.; Linares, G.G.; Bujjamer, J.M.; Gorojod, R.M.; Alcon, S.P.; Martinez, J.H.; Baldessari, A.; Grecco, H.E.; Kotler, M.L. url  doi
openurl 
  Title Toxicity of blue led light and A2E is associated to mitochondrial dynamics impairment in ARPE-19 cells: implications for age-related macular degeneration Type Journal Article
  Year 2019 Publication Archives of Toxicology Abbreviated Journal Arch Toxicol  
  Volume 93 Issue 5 Pages 1401-1415  
  Keywords Vision; age-related macular degeneration; Eye; Eye Diseases; blue light  
  Abstract Age-related macular degeneration (AMD) is a multifactorial retinal disease characterized by a progressive loss of central vision. Retinal pigment epithelium (RPE) degeneration is a critical event in AMD. It has been associated to A2E accumulation, which sensitizes RPE to blue light photodamage. Mitochondrial quality control mechanisms have evolved to ensure mitochondrial integrity and preserve cellular homeostasis. Particularly, mitochondrial dynamics involve the regulation of mitochondrial fission and fusion to preserve a healthy mitochondrial network. The present study aims to clarify the cellular and molecular mechanisms underlying photodamage-induced RPE cell death with particular focus on the involvement of defective mitochondrial dynamics. Light-emitting diodes irradiation (445 +/- 18 nm; 4.43 mW/cm(2)) significantly reduced the viability of both unloaded and A2E-loaded human ARPE-19 cells and increased reactive oxygen species production. A2E along with blue light, triggered apoptosis measured by MC540/PI-flow cytometry and activated caspase-3. Blue light induced mitochondrial fusion/fission imbalance towards mitochondrial fragmentation in both non-loaded and A2E-loaded cells which correlated with the deregulation of mitochondria-shaping proteins level (OPA1, DRP1 and OMA1). To our knowledge, this is the first work reporting that photodamage causes mitochondrial dynamics deregulation in RPE cells. This process could possibly contribute to AMD pathology. Our findings suggest that the regulation of mitochondrial dynamics may be a valuable strategy for treating retinal degeneration diseases, such as AMD.  
  Address Departamento de Quimica Biologica, Facultad de Ciencias Exactas y Naturales, Instituto de Quimica Biologica Ciencias Exactas y Naturales (IQUIBICEN), CONICET-Universidad de Buenos Aires, Pabellon 2, Ciudad Universitaria, 1428, Buenos Aires, Argentina. kotler@qb.fcen.uba.ar  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0340-5761 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:30778631 Approved no  
  Call Number (up) GFZ @ kyba @ Serial 2229  
Permanent link to this record
 

 
Author Pagden, M.; Ngahane, K.; Amin, M.S.R. url  doi
openurl 
  Title Changing the colour of night on urban streets – LED vs. part-night lighting system Type Journal Article
  Year 2019 Publication Socio-Economic Planning Sciences Abbreviated Journal Socio-Economic Planning Sciences  
  Volume in press Issue Pages 100692  
  Keywords Energy; Planning; Economics; United Kingdom; LED; Lighting  
  Abstract Many cities in the United Kingdom are upgrading the streetlights to white light-emitting diode (LED) lamps for reducing the electricity costs and attaining the sustainable energy solutions. Installation of LED lamps on urban street requires higher installation costs and a long-term period to payback benefits of replacing outdated streetlights in terms of energy savings and costs. To achieve the short-term energy efficiency of urban street lighting, city councils sometimes adopt the part-night lighting system particularly in the residential areas. The Coventry City Council recently replaced 29,701 existing sodium lights with LED lamps. This paper performs the economic analyses to understand the feasibility of two street lighting systems: LED lamps and ‘part-night’ lightings on the Coventry streets during the twenty-year period assuming the return period of investment is twenty years. The projection of energy consumption and costs for LED lamps and part-night lighting systems shows that electricity can be saved by 44% and 21% comparing to current electricity usages, respectively. Considering the budgetary constraints of Coventry City Council, this paper concludes that the part-night lighting system may be beneficial in short-term period, but it is economically feasible to replace the existing lower efficiency lights with LED lamps.  
  Address Faculty of Engineering, Environment & Computing, Coventry University, Priory St, Coventry, West Midlands, CV1 5FB, United Kingdom; pagdenm(at)uni.coventry.ac.uk  
  Corporate Author Thesis  
  Publisher English Place of Publication Editor  
  Language English Summary Language English Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0038-0121 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number (up) GFZ @ kyba @ Serial 2234  
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Author Zhang, K.; Zhong, X.; Zhang, G.; Li, D.; Su, Z.; Meng, Y.; Jiang, Y. url  doi
openurl 
  Title Thermal Stability Optimization of the Luojia 1-01 Nighttime Light Remote-Sensing Camera's Principal Distance Type Journal Article
  Year 2019 Publication Sensors (Basel, Switzerland) Abbreviated Journal Sensors (Basel)  
  Volume 19 Issue 5 Pages 990  
  Keywords Instrumentation; Luojia 1-01; nighttime light remote-sensing camera; principal distance; optical-passive athermal design; thermal stability  
  Abstract The instability of the principal distance of the nighttime light remote-sensing camera of the Luojia 1-01 satellite directly affects the geometric accuracy of images, consequently affecting the results of analysis of nighttime light remote-sensing data. Based on the theory of optical passive athermal design, a mathematical model of optical-passive athermal design for principal distance stabilization is established. Positive and negative lenses of different materials and the mechanical structures of different materials are matched to optimize the optical system. According to the index requirements of the Luojia 1-01 camera, an image-telecentric optical system was designed under the guidance of the established mathematical model. In the temperature range of -20 degrees C to +60 degrees C, the principal distance of the system changes from -0.01 mum to +0.28 mum. After on-orbit testing, the geometric accuracy of the designed nighttime light remote-sensing camera is better than 0.20 pixels and less than index requirement of 0.3 pixels, which indicating that the principal distance maintains good stability on-orbit and meets the application requirements of nighttime light remote sensing.  
  Address School of Remote Sensing and Information Engineering, Wuhan University, Wuhan 430079, China. jiangyh@whu.edu.cn  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1424-8220 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:30813556 Approved no  
  Call Number (up) GFZ @ kyba @ Serial 2238  
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Author Nagare, R.; Rea, M.S.; Plitnick, B.; Figueiro, M.G. url  doi
openurl 
  Title Effect of White Light Devoid of “Cyan” Spectrum Radiation on Nighttime Melatonin Suppression Over a 1-h Exposure Duration Type Journal Article
  Year 2019 Publication Journal of Biological Rhythms Abbreviated Journal J Biol Rhythms  
  Volume 34 Issue 2 Pages 195-204  
  Keywords Human Health; melatonin; melatonin suppression; cyan light  
  Abstract The intrinsically photosensitive retinal ganglion cells are the main conduit of the light signal emanating from the retina to the biological clock located in the suprachiasmatic nuclei of the hypothalamus. Lighting manufacturers are developing white light sources that are devoid of wavelengths around 480 nm (“cyan gap”) to reduce their impact on the circadian system. The present study was designed to investigate whether exposure to a “cyan-gap,” 3000 K white light source, spectrally tuned to reduce radiant power between 475 and 495 nm (reducing stimulation of the melanopsin-containing photoreceptor), would suppress melatonin less than a conventional 3000 K light source. The study's 2 phases employed a within-subjects experimental design involving the same 16 adult participants. In Phase 1, participants were exposed for 1 h to 3 experimental conditions over the course of 3 consecutive weeks: 1) dim light control (<5 lux at the eyes); 2) 800 lux at the eyes of a 3000 K light source; and 3) 800 lux at the eyes of a 3000 K, “cyan-gap” modified (3000 K mod) light source. The same protocol was repeated in Phase 2, but light levels were reduced to 400 lux at the eyes. As hypothesized, there were significant main effects of light level ( F1,12 = 9.1, p < 0.05, etap(2) = 0.43) and exposure duration ( F1,12 = 47.7, p < 0.05, etap(2) = 0.80) but there was no significant main effect of spectrum ( F1,12 = 0.16, p > 0.05, etap(2) = 0.01). There were no significant interactions with spectrum. Contrary to our model predictions, our results showed that short-term exposures (</= 1 h) to “cyan-gap” light sources suppressed melatonin similarly to conventional light sources of the same CCT and photopic illuminance at the eyes.  
  Address Lighting Research Center, Rensselaer Polytechnic Institute, Troy, NY, USA  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0748-7304 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:30821188 Approved no  
  Call Number (up) GFZ @ kyba @ Serial 2240  
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Author Entwistle, J.; Slater, D. url  doi
openurl 
  Title Making space for 'the social': connecting sociology and professional practices in urban lighting design Type Journal Article
  Year 2019 Publication The British Journal of Sociology Abbreviated Journal Br J Sociol  
  Volume 70 Issue 5 Pages 2020-2041  
  Keywords Sociology; Society; Lighting  
  Abstract Lighting is increasingly recognized as a significant social intervention by both lighting professionals and academic social scientists. However, what counts as 'the social' is diverse and contested, with consequences for what kind of 'social' is performed or invented. Based on a long-term research programme, we argue that collaboration between sociologists and lighting professionals requires negotiating discourses and practices of 'the social'. This paper explores the quality and kinds of spaces made for 'the social' in professional practices and academic collaborations, focusing on two case studies of urban lighting that demonstrate how the space of 'the social' is constrained and impoverished by an institutionalized division between technical and aesthetic lighting. We consider the potential role of sociologists in making more productive spaces for 'the social' in urban design, as part of the central sociological task of 'inventing the social' (Marres, Guggenheim and Wilkie 2018) in the process of studying it.  
  Address Department of Sociology, London School of Economics; d.slater(at)lse.ac.uk  
  Corporate Author Thesis  
  Publisher Wiley Place of Publication Editor  
  Language English Summary Language English Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0007-1315 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:30864152 Approved no  
  Call Number (up) GFZ @ kyba @ Serial 2265  
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