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Author Nadis, S. url  doi
openurl 
  Title Biologists join drive to turn down the lights Type
  Year 2002 Publication Nature Abbreviated Journal Nature  
  Volume 419 Issue 6910 Pages 868  
  Keywords Ecology; Animal Migration; Animals; Astronomical Phenomena; Astronomy; Biology/*trends; Breast Neoplasms/etiology; Environment; Environmental Pollution/*adverse effects/prevention & control; Female; Humans; Light/*adverse effects; Male; Risk Factors; Vision, Ocular/physiology  
  Abstract  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0028-0836 ISBN Medium  
  Area Expedition Conference  
  Notes (up) PMID:12410271 Approved no  
  Call Number LoNNe @ kagoburian @ Serial 787  
Permanent link to this record
 

 
Author Schernhammer, E.S.; Schulmeister, K. url  doi
openurl 
  Title Melatonin and cancer risk: does light at night compromise physiologic cancer protection by lowering serum melatonin levels? Type Journal Article
  Year 2004 Publication British Journal of Cancer Abbreviated Journal Br J Cancer  
  Volume 90 Issue 5 Pages 941-943  
  Keywords Human Health; Animals; Circadian Rhythm/*radiation effects; Humans; Light/*adverse effects; Melatonin/*blood; Neoplasms/blood/*etiology; Risk Factors  
  Abstract The suprachiasmatic nuclei in the hypothalamus, one of the most important physiological determinants of alertness and performance, drive a circadian pacemaker in mammals, with an intrinsic period averaging 24 h. Light is the primary stimulus to the disruption and resetting of this pacemaker, which is expressed in changing melatonin rhythms. Melatonin production in humans decreases when people are exposed to light at night. Since melatonin shows potential oncostatic action in a variety of tumours, it is possible that lowered serum melatonin levels caused by exposure to light at night enhance the general tumour development. Cancer is the second leading cause of death in industrialised countries like the United States, where a significant proportion of workers engage in shift work, making a hypothesised relation between light exposure at night and cancer risk relevant. Observational studies support an association between night work and cancer risk. We hypothesise that the potential primary culprit for this observed association is the lack of melatonin, a cancer-protective agent whose production is severely diminished in people exposed to light at night.  
  Address Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA. eva.schernhammer@channing.harvard.edu  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0007-0920 ISBN Medium  
  Area Expedition Conference  
  Notes (up) PMID:14997186; PMCID:PMC2409637 Approved no  
  Call Number LoNNe @ kagoburian @ Serial 805  
Permanent link to this record
 

 
Author Fonken, L.K.; Finy, M.S.; Walton, J.C.; Weil, Z.M.; Workman, J.L.; Ross, J.; Nelson, R.J. url  doi
openurl 
  Title Influence of light at night on murine anxiety- and depressive-like responses Type Journal Article
  Year 2009 Publication Behavioural Brain Research Abbreviated Journal Behav Brain Res  
  Volume 205 Issue 2 Pages 349-354  
  Keywords Human Health; Animals; Anxiety/*physiopathology; Corticosterone/blood; Depression/*physiopathology; Dietary Sucrose/administration & dosage; Drinking Behavior/physiology; Light/*adverse effects; Lighting; Locomotion/physiology; Male; Maze Learning; Mice; Neuropsychological Tests; Organ Size; Photic Stimulation; *Photoperiod; Random Allocation; Swimming; Testis/pathology  
  Abstract Individuals are increasingly exposed to light at night. Exposure to constant light (LL) disrupts circadian rhythms of locomotor activity, body temperature, hormones, and the sleep-wake cycle in animals. Other behavioural responses to LL have been reported, but are inconsistent. The present experiment sought to determine whether LL produces changes in affective responses and whether behavioural changes are mediated by alterations in glucocorticoid concentrations. Relative to conspecifics maintained in a light/dark cycle (LD, 16:8 light/dark), male Swiss-Webster mice exposed to LL for three weeks increased depressive-like behavioural responses as evaluated by the forced swim test and sucrose anhedonia. Furthermore, providing a light escape tube reversed the effects of LL in the forced swim test. LL mice displayed reduced anxiety as evaluated by the open field and elevated-plus maze. Glucocorticoid concentrations were reduced in the LL group suggesting that the affective behavioural responses to LL are not the result of elevated corticosterone. Additionally, mice housed in LD with a clear tube displayed increased paired testes mass as compared to LL mice. Taken together, these data provide evidence that exposure to unnatural lighting can induce significant changes in affect, increasing depressive-like and decreasing anxiety-like responses.  
  Address Department of Psychology, The Ohio State University, Columbus, OH 43210, USA. Fonken.1@osu.edu  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0166-4328 ISBN Medium  
  Area Expedition Conference  
  Notes (up) PMID:19591880 Approved no  
  Call Number LoNNe @ kagoburian @ Serial 749  
Permanent link to this record
 

 
Author Reiter, R.J.; Tan, D.X.; Erren, T.C.; Fuentes-Broto, L.; Paredes, S.D. url  doi
openurl 
  Title Light-mediated perturbations of circadian timing and cancer risk: a mechanistic analysis Type Journal Article
  Year 2009 Publication Integrative Cancer Therapies Abbreviated Journal Integr Cancer Ther  
  Volume 8 Issue 4 Pages 354-360  
  Keywords *Circadian Rhythm; Humans; Light/*adverse effects; Melatonin/antagonists & inhibitors; Neoplasms/*etiology/physiopathology; Risk Factors; Sleep Deprivation/complications; oncogenesis  
  Abstract In industrialized countries, certain types of cancer, most notably, breast and prostate, are more frequent than in poorly developed nations. This high cancer frequency is not explained by any of the conventional causes. Within the past decade, numerous reports have appeared that link light at night with an elevated cancer risk. The three major consequences of light at night are sleep deprivation, chronodisruption, and melatonin suppression. Each of these individually or in combination may contribute to the reported rise in certain types of cancer. In this article, the potential mechanisms underlying the basis of the elevated cancer risk are briefly discussed. Finally, if cancer is a consequence of excessive nighttime light, it is likely that other diseases/conditions may also be exaggerated by the widespread use of light after darkness onset.  
  Address Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, TX 78229, USA. reiter@uthscsa.edu  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1534-7354 ISBN Medium  
  Area Expedition Conference  
  Notes (up) PMID:20042411 Approved no  
  Call Number IDA @ john @ Serial 290  
Permanent link to this record
 

 
Author Hölker, F.; Wolter, C.; Perkin, E.K.; Tockner, K. url  doi
openurl 
  Title Light pollution as a biodiversity threat Type Journal Article
  Year 2010 Publication Trends in Ecology & Evolution Abbreviated Journal Trends Ecol Evol  
  Volume 25 Issue 12 Pages 681-682  
  Keywords *Biodiversity; Biological Clocks; Biological Evolution; Ecosystem; *Environmental Monitoring; *Environmental Pollutants; Light/*adverse effects  
  Abstract  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0169-5347 ISBN Medium  
  Area Expedition Conference  
  Notes (up) PMID:21035893 Approved no  
  Call Number IDA @ john @ Serial 36  
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