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Author |
Wood, B.; Rea, M.S.; Plitnick, B.; Figueiro, M.G. |

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Title |
Light level and duration of exposure determine the impact of self-luminous tablets on melatonin suppression |
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Journal Article |
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Year |
2013 |
Publication |
Applied Ergonomics |
Abbreviated Journal |
Appl Ergon |
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Volume |
44 |
Issue |
2 |
Pages |
237-240 |
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Keywords |
Adolescent; *Computers, Handheld; Female; Humans; Light/*adverse effects; Male; Melatonin/*biosynthesis; Photoperiod; Saliva/*metabolism; Sleep/radiation effects; Time Factors; Young Adult; melatonin |
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Abstract |
Exposure to light from self-luminous displays may be linked to increased risk for sleep disorders because these devices emit optical radiation at short wavelengths, close to the peak sensitivity of melatonin suppression. Thirteen participants experienced three experimental conditions in a within-subjects design to investigate the impact of self-luminous tablet displays on nocturnal melatonin suppression: 1) tablets-only set to the highest brightness, 2) tablets viewed through clear-lens goggles equipped with blue light-emitting diodes that provided 40 lux of 470-nm light at the cornea, and 3) tablets viewed through orange-tinted glasses (dark control; optical radiation <525 nm approximately 0). Melatonin suppressions after 1-h and 2-h exposures to tablets viewed with the blue light were significantly greater than zero. Suppression levels after 1-h exposure to the tablets-only were not statistically different than zero; however, this difference reached significance after 2 h. Based on these results, display manufacturers can determine how their products will affect melatonin levels and use model predictions to tune the spectral power distribution of self-luminous devices to increase or to decrease stimulation to the circadian system. |
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Lighting Research Center, Rensselaer Polytechnic Institute, 21 Union Street, Troy, NY 12180, USA. woodb5@rpi.edu |
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0003-6870 |
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PMID:22850476 |
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IDA @ john @ |
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136 |
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Author |
Obayashi, K.; Saeki, K.; Iwamoto, J.; Ikada, Y.; Kurumatani, N. |

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Title |
Exposure to light at night and risk of depression in the elderly |
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Journal Article |
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Year |
2013 |
Publication |
Journal of Affective Disorders |
Abbreviated Journal |
J Affect Disord |
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Volume |
151 |
Issue |
1 |
Pages |
331-336 |
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Keywords |
Aged; Circadian Rhythm; Cross-Sectional Studies; Depression/*etiology; Female; Humans; Light/*adverse effects; Male; Melatonin/urine; Psychiatric Status Rating Scales; Risk Factors; Circadian rhythm; Daytime light; Depression; Elderly; Light at night; Melatonin; Mental Health |
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Abstract |
BACKGROUND: Recent advances in understanding the fundamental links between chronobiology and depressive disorders have enabled exploring novel risk factors for depression in the field of biological rhythms. Increased exposure to light at night (LAN) is common in modern life, and LAN exposure is associated with circadian misalignment. However, whether LAN exposure in home settings is associated with depression remains unclear. METHODS: We measured the intensities of nighttime bedroom light and ambulatory daytime light along with overnight urinary melatonin excretion (UME) in 516 elderly individuals (mean age, 72.8). Depressive symptoms were assessed using the Geriatric Depression Scale. RESULTS: The median nighttime light intensity was 0.8lx (interquartile range, 0.2-3.3). The depressed group (n=101) revealed significantly higher prevalence of LAN exposure (average intensity, >/= 5 lx) compared with that of the nondepressed group (n=415) using a multivariate logistic regression model adjusted for daytime light exposure, insomnia, hypertension, sleep duration, and physical activity [adjusted odds ratio (OR): 1.89; 95% confidence interval (CI), 1.10-3.25; P=0.02]. Consistently, another parameter of LAN exposure (duration of intensity >/= 10 lx, >/= 30 min) was significantly more prevalent in the depressed than in the nondepressed group (adjusted OR: 1.71; 95% CI, 1.01-2.89; P=0.046). In contrast, UME was not significantly associated with depressive symptoms. LIMITATION: Cross-sectional analysis. CONCLUSION: These results suggested that LAN exposure in home settings is significantly associated with depressive symptoms in the general elderly population. The risk of depression may be reduced by keeping nighttime bedroom dark. |
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Department of Community Health and Epidemiology, Nara Medical University School of Medicine, Nara, Japan. obayashi@naramed-u.ac.jp |
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0165-0327 |
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PMID:23856285 |
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IDA @ john @ |
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165 |
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Author |
Reiter, R.J.; Tan, D.X.; Erren, T.C.; Fuentes-Broto, L.; Paredes, S.D. |

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Title |
Light-mediated perturbations of circadian timing and cancer risk: a mechanistic analysis |
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Journal Article |
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Year |
2009 |
Publication |
Integrative Cancer Therapies |
Abbreviated Journal |
Integr Cancer Ther |
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8 |
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4 |
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354-360 |
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*Circadian Rhythm; Humans; Light/*adverse effects; Melatonin/antagonists & inhibitors; Neoplasms/*etiology/physiopathology; Risk Factors; Sleep Deprivation/complications; oncogenesis |
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In industrialized countries, certain types of cancer, most notably, breast and prostate, are more frequent than in poorly developed nations. This high cancer frequency is not explained by any of the conventional causes. Within the past decade, numerous reports have appeared that link light at night with an elevated cancer risk. The three major consequences of light at night are sleep deprivation, chronodisruption, and melatonin suppression. Each of these individually or in combination may contribute to the reported rise in certain types of cancer. In this article, the potential mechanisms underlying the basis of the elevated cancer risk are briefly discussed. Finally, if cancer is a consequence of excessive nighttime light, it is likely that other diseases/conditions may also be exaggerated by the widespread use of light after darkness onset. |
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Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, TX 78229, USA. reiter@uthscsa.edu |
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1534-7354 |
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PMID:20042411 |
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IDA @ john @ |
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290 |
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Fonken, L.K.; Finy, M.S.; Walton, J.C.; Weil, Z.M.; Workman, J.L.; Ross, J.; Nelson, R.J. |

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Title |
Influence of light at night on murine anxiety- and depressive-like responses |
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Journal Article |
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2009 |
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Behavioural Brain Research |
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Behav Brain Res |
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205 |
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2 |
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349-354 |
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Human Health; Animals; Anxiety/*physiopathology; Corticosterone/blood; Depression/*physiopathology; Dietary Sucrose/administration & dosage; Drinking Behavior/physiology; Light/*adverse effects; Lighting; Locomotion/physiology; Male; Maze Learning; Mice; Neuropsychological Tests; Organ Size; Photic Stimulation; *Photoperiod; Random Allocation; Swimming; Testis/pathology |
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Individuals are increasingly exposed to light at night. Exposure to constant light (LL) disrupts circadian rhythms of locomotor activity, body temperature, hormones, and the sleep-wake cycle in animals. Other behavioural responses to LL have been reported, but are inconsistent. The present experiment sought to determine whether LL produces changes in affective responses and whether behavioural changes are mediated by alterations in glucocorticoid concentrations. Relative to conspecifics maintained in a light/dark cycle (LD, 16:8 light/dark), male Swiss-Webster mice exposed to LL for three weeks increased depressive-like behavioural responses as evaluated by the forced swim test and sucrose anhedonia. Furthermore, providing a light escape tube reversed the effects of LL in the forced swim test. LL mice displayed reduced anxiety as evaluated by the open field and elevated-plus maze. Glucocorticoid concentrations were reduced in the LL group suggesting that the affective behavioural responses to LL are not the result of elevated corticosterone. Additionally, mice housed in LD with a clear tube displayed increased paired testes mass as compared to LL mice. Taken together, these data provide evidence that exposure to unnatural lighting can induce significant changes in affect, increasing depressive-like and decreasing anxiety-like responses. |
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Department of Psychology, The Ohio State University, Columbus, OH 43210, USA. Fonken.1@osu.edu |
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0166-4328 |
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PMID:19591880 |
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LoNNe @ kagoburian @ |
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749 |
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Author |
Kloog, I.; Portnov, B.A.; Rennert, H.S.; Haim, A. |

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Title |
Does the modern urbanized sleeping habitat pose a breast cancer risk? |
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Journal Article |
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Year |
2011 |
Publication |
Chronobiology International |
Abbreviated Journal |
Chronobiol Int |
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28 |
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1 |
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76-80 |
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Human Health; ged; Alcohol Drinking/adverse effects; Breast Neoplasms/*etiology; Case-Control Studies; Circadian Rhythm/*radiation effects; Female; Humans; Light/*adverse effects; Middle Aged; Odds Ratio; Risk Factors; *Sleep; Urbanization |
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Due to its disruptive effects on circadian rhythms and sleep deprivation at night, shiftworking is currently recognized as a risk factor for breast cancer (BC). As revealed by the present analysis based on a comparative case-control study of 1679 women, exposure to light-at-night (LAN) in the “sleeping habitat” is significantly associated with BC risk (odds ratio [OR] = 1.220, 95% confidence interval [CI] = 1.118-1.311; p < .001), controlling for education, ethnicity, fertility, and alcohol consumption. The novelty of the present research is that, to the best of the authors' knowledge, it is the first study to have identified an unequivocal positive association between bedroom-light intensity and BC risk. Thus, according to the results of the present study, not only should artificial light exposure in the working environment be considered as a potential risk factor for BC, but also LAN in the “sleeping habitat.” |
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Department of Natural Resources and Environmental Management, Graduate School of Management, University of Haifa, Haifa, Israel |
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ISSN |
0742-0528 |
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PMID:21182407 |
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LoNNe @ kagoburian @ |
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770 |
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