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Author Leccese, F.; Leonowicz, Z. url  openurl
  Title Intelligent wireless street lighting system. Type Journal Article
  Year 2012 Publication (up) Environmental and Electrical Engineering, 11th International Conference Abbreviated Journal  
  Volume Issue Pages 958–961  
  Keywords Lighting  
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  Area Expedition Conference  
  Notes Approved no  
  Call Number LoNNe @ kagoburian @ Serial 642  
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Author Shang, Y.-M.; Wang, G.-S.; Sliney, D.; Yang, C.-H.; Lee, L.-L. url  doi
openurl 
  Title White light-emitting diodes (LEDs) at domestic lighting levels and retinal injury in a rat model Type Journal Article
  Year 2014 Publication (up) Environmental Health Perspectives Abbreviated Journal Environ Health Perspect  
  Volume 122 Issue 3 Pages 269-276  
  Keywords LED; light emitting diode; lighting; retina; Eye Diseases; blue light; Blue-rich light sources  
  Abstract BACKGROUND: Light-emitting diodes (LEDs) deliver higher levels of blue light to the retina than do conventional domestic light sources. Chronic exposure to high-intensity light (2,000-10,000 lux) has previously been found to result in light-induced retinal injury, but chronic exposure to relatively low-intensity (750 lux) light has not been previously assessed with LEDs in a rodent model. OBJECTIVE: We examined LED-induced retinal neuronal cell damage in the Sprague-Dawley rat using functional, histological, and biochemical measurements. METHODS: We used blue LEDs (460 nm) and full-spectrum white LEDs, coupled with matching compact fluorescent lights, for exposures. Pathological examinations included electroretinogram, hematoxylin and eosin (H&E) staining, immunohistochemistry (IHC), and transmission electron microscopy (TEM). We also measured free radical production in the retina to determine the oxidative stress level. RESULTS: H&E staining and TEM revealed apoptosis and necrosis of photoreceptors, which indicated blue-light induced photochemical injury of the retina. Free radical production in the retina was increased in LED-exposed groups. IHC staining demonstrated that oxidative stress was associated with retinal injury. Although we found serious retinal light injury in LED groups, the compact fluorescent lamp (CFL) groups showed moderate to mild injury. CONCLUSION: Our results raise questions about adverse effects on the retina from chronic exposure to LED light compared with other light sources that have less blue light. Thus, we suggest a precautionary approach with regard to the use of blue-rich “white” LEDs for general lighting. CITATION: Shang YM, Wang GS, Sliney D, Yang CH, Lee LL. 2014. White light-emitting diodes (LEDs) at domestic lighting levels and retinal injury in a rat model. Environ Health Perspect 122:269-276; http://dx.doi.org/10.1289/ehp.1307294.  
  Address Institute of Environmental Health, National Taiwan University, Taipei, Taiwan  
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  Language English Summary Language Original Title  
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  Series Volume Series Issue Edition  
  ISSN 0091-6765 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:24362357; PMCID:PMC3948037 Approved no  
  Call Number IDA @ john @ Serial 324  
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Author Spivey, A. url  doi
openurl 
  Title Light at night and breast cancer risk worldwide Type
  Year 2010 Publication (up) Environmental Health Perspectives Abbreviated Journal Environ Health Perspect  
  Volume 118 Issue 12 Pages a525  
  Keywords Human Health; Breast Neoplasms/epidemiology/*etiology/prevention & control; Female; Humans; Lighting/*adverse effects; Male; Prostatic Neoplasms/epidemiology/*etiology/prevention & control; Risk Factors  
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  Language English Summary Language Original Title  
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  ISSN 0091-6765 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:21123149; PMCID:PMC3002207 Approved no  
  Call Number LoNNe @ kagoburian @ Serial 813  
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Author Stevens, R.G.; Blask, D.E.; Brainard, G.C.; Hansen, J.; Lockley, S.W.; Provencio, I.; Rea, M.S.; Reinlib, L. url  doi
openurl 
  Title Meeting report: the role of environmental lighting and circadian disruption in cancer and other diseases Type Journal Article
  Year 2007 Publication (up) Environmental Health Perspectives Abbreviated Journal Environ Health Perspect  
  Volume 115 Issue 9 Pages 1357-1362  
  Keywords Human Health; Animals; *Circadian Rhythm; Environmental Exposure; Humans; *Lighting/adverse effects; *Neoplasms/etiology; Research; breast cancer; circadian rhythms; clock genes; lighting; melatonin; phototransduction; pineal gland  
  Abstract Light, including artificial light, has a range of effects on human physiology and behavior and can therefore alter human physiology when inappropriately timed. One example of potential light-induced disruption is the effect of light on circadian organization, including the production of several hormone rhythms. Changes in light-dark exposure (e.g., by nonday occupation or transmeridian travel) shift the timing of the circadian system such that internal rhythms can become desynchronized from both the external environment and internally with each other, impairing our ability to sleep and wake at the appropriate times and compromising physiologic and metabolic processes. Light can also have direct acute effects on neuroendocrine systems, for example, in suppressing melatonin synthesis or elevating cortisol production that may have untoward long-term consequences. For these reasons, the National Institute of Environmental Health Sciences convened a workshop of a diverse group of scientists to consider how best to conduct research on possible connections between lighting and health. According to the participants in the workshop, there are three broad areas of research effort that need to be addressed. First are the basic biophysical and molecular genetic mechanisms for phototransduction for circadian, neuroendocrine, and neurobehavioral regulation. Second are the possible physiologic consequences of disrupting these circadian regulatory processes such as on hormone production, particularly melatonin, and normal and neoplastic tissue growth dynamics. Third are effects of light-induced physiologic disruption on disease occurrence and prognosis, and how prevention and treatment could be improved by application of this knowledge.  
  Address Department of Community Medicine, University of Connecticut Health Center, Farmington, Connecticut 06030-6325, USA. bugs@uchc.edu  
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  ISSN 0091-6765 ISBN Medium  
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  Notes PMID:17805428; PMCID:PMC1964886 Approved no  
  Call Number LoNNe @ kagoburian @ Serial 821  
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Author Garcia-Saenz, A.; Sanchez de Miguel, A.; Espinosa, A.; Valentin, A.; Aragones, N.; Llorca, J.; Amiano, P.; Martin Sanchez, V.; Guevara, M.; Capelo, R.; Tardon, A.; Peiro-Perez, R.; Jimenez-Moleon, J.J.; Roca-Barcelo, A.; Perez-Gomez, B.; Dierssen-Sotos, T.; Fernandez-Villa, T.; Moreno-Iribas, C.; Moreno, V.; Garcia-Perez, J.; Castano-Vinyals, G.; Pollan, M.; Aube, M.; Kogevinas, M. url  doi
openurl 
  Title Evaluating the Association between Artificial Light-at-Night Exposure and Breast and Prostate Cancer Risk in Spain (MCC-Spain Study) Type Journal Article
  Year 2018 Publication (up) Environmental Health Perspectives Abbreviated Journal Environ Health Perspect  
  Volume 126 Issue 4 Pages 047011  
  Keywords Human Health; Remote Sensing; Adult; Aged; Aged, 80 and over; Breast Neoplasms/*epidemiology/etiology; Case-Control Studies; Circadian Rhythm; Female; Humans; Incidence; Light/*adverse effects; Lighting/*adverse effects; Male; Middle Aged; Prostatic Neoplasms/*epidemiology/etiology; Risk Factors; Spain/epidemiology; Young Adult  
  Abstract BACKGROUND: Night shift work, exposure to light at night (ALAN) and circadian disruption may increase the risk of hormone-dependent cancers. OBJECTIVES: We evaluated the association of exposure to ALAN during sleeping time with breast and prostate cancer in a population based multicase-control study (MCC-Spain), among subjects who had never worked at night. We evaluated chronotype, a characteristic that may relate to adaptation to light at night. METHODS: We enrolled 1,219 breast cancer cases, 1,385 female controls, 623 prostate cancer cases, and 879 male controls from 11 Spanish regions in 2008-2013. Indoor ALAN information was obtained through questionnaires. Outdoor ALAN was analyzed using images from the International Space Station (ISS) available for Barcelona and Madrid for 2012-2013, including data of remotely sensed upward light intensity and blue light spectrum information for each geocoded longest residence of each MCC-Spain subject. RESULTS: Among Barcelona and Madrid participants with information on both indoor and outdoor ALAN, exposure to outdoor ALAN in the blue light spectrum was associated with breast cancer [adjusted odds ratio (OR) for highest vs. lowest tertile, OR=1.47; 95% CI: 1.00, 2.17] and prostate cancer (OR=2.05; 95% CI: 1.38, 3.03). In contrast, those exposed to the highest versus lowest intensity of outdoor ALAN were more likely to be controls than cases, particularly for prostate cancer. Compared with those who reported sleeping in total darkness, men who slept in “quite illuminated” bedrooms had a higher risk of prostate cancer (OR=2.79; 95% CI: 1.55, 5.04), whereas women had a slightly lower risk of breast cancer (OR=0.77; 95% CI: 0.39, 1.51). CONCLUSION: Both prostate and breast cancer were associated with high estimated exposure to outdoor ALAN in the blue-enriched light spectrum. https://doi.org/10.1289/EHP1837.  
  Address IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain  
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  ISSN 0091-6765 ISBN Medium  
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  Notes PMID:29687979; PMCID:PMC6071739 Approved no  
  Call Number GFZ @ kyba @ Serial 3044  
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