| Records |
Author  |
Yasuniwa, Y.; Izumi, H.; Wang, K.-Y.; Shimajiri, S.; Sasaguri, Y.; Kawai, K.; Kasai, H.; Shimada, T.; Miyake, K.; Kashiwagi, E.; Hirano, G.; Kidani, A.; Akiyama, M.; Han, B.; Wu, Y.; Ieiri, I.; Higuchi, S.; Kohno, K. |
| Title |
Circadian disruption accelerates tumor growth and angio/stromagenesis through a Wnt signaling pathway |
Type |
Journal Article |
| Year |
2010 |
Publication |
PloS one |
Abbreviated Journal |
PLoS One |
| Volume |
5 |
Issue |
12 |
Pages |
e15330 |
| Keywords |
Animals; *Circadian Rhythm; Disease Progression; *Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Neoplasms/*pathology; *Neovascularization, Pathologic; Nerve Tissue Proteins/metabolism; Skin/metabolism; Vascular Endothelial Growth Factor A/metabolism; Wnt Proteins/*metabolism; Oncogenesis |
| Abstract |
Epidemiologic studies show a high incidence of cancer in shift workers, suggesting a possible relationship between circadian rhythms and tumorigenesis. However, the precise molecular mechanism played by circadian rhythms in tumor progression is not known. To identify the possible mechanisms underlying tumor progression related to circadian rhythms, we set up nude mouse xenograft models. HeLa cells were injected in nude mice and nude mice were moved to two different cases, one case is exposed to a 24-hour light cycle (L/L), the other is a more “normal” 12-hour light/dark cycle (L/D). We found a significant increase in tumor volume in the L/L group compared with the L/D group. In addition, tumor microvessels and stroma were strongly increased in L/L mice. Although there was a hypervascularization in L/L tumors, there was no associated increase in the production of vascular endothelial cell growth factor (VEGF). DNA microarray analysis showed enhanced expression of WNT10A, and our subsequent study revealed that WNT10A stimulates the growth of both microvascular endothelial cells and fibroblasts in tumors from light-stressed mice, along with marked increases in angio/stromagenesis. Only the tumor stroma stained positive for WNT10A and WNT10A is also highly expressed in keloid dermal fibroblasts but not in normal dermal fibroblasts indicated that WNT10A may be a novel angio/stromagenic growth factor. These findings suggest that circadian disruption induces the progression of malignant tumors via a Wnt signaling pathway. |
| Address |
Department of Molecular Biology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan |
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| Language |
English |
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| ISSN |
1932-6203 |
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| Notes |
PMID:21203463; PMCID:PMC3009728 |
Approved |
no |
| Call Number |
IDA @ john @ |
Serial |
162 |
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| Author |
Wright, K.P.J.; McHill, A.W.; Birks, B.R.; Griffin, B.R.; Rusterholz, T.; Chinoy, E.D. |
| Title |
Entrainment of the human circadian clock to the natural light-dark cycle |
Type |
Journal Article |
| Year |
2013 |
Publication |
Current Biology : CB |
Abbreviated Journal |
Curr Biol |
| Volume |
23 |
Issue |
16 |
Pages |
1554-1558 |
| Keywords |
Human Health; Adult; Circadian Clocks/*radiation effects; Female; Humans; *Lighting; Male; *Photoperiod; *Sunlight; Young Adult; Circadian Rhythm |
| Abstract |
The electric light is one of the most important human inventions. Sleep and other daily rhythms in physiology and behavior, however, evolved in the natural light-dark cycle [1], and electrical lighting is thought to have disrupted these rhythms. Yet how much the age of electrical lighting has altered the human circadian clock is unknown. Here we show that electrical lighting and the constructed environment is associated with reduced exposure to sunlight during the day, increased light exposure after sunset, and a delayed timing of the circadian clock as compared to a summer natural 14 hr 40 min:9 hr 20 min light-dark cycle camping. Furthermore, we find that after exposure to only natural light, the internal circadian clock synchronizes to solar time such that the beginning of the internal biological night occurs at sunset and the end of the internal biological night occurs before wake time just after sunrise. In addition, we find that later chronotypes show larger circadian advances when exposed to only natural light, making the timing of their internal clocks in relation to the light-dark cycle more similar to earlier chronotypes. These findings have important implications for understanding how modern light exposure patterns contribute to late sleep schedules and may disrupt sleep and circadian clocks. |
| Address |
Sleep and Chronobiology Laboratory, Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO 80309-0354, USA. kenneth.wright@colorado.edu |
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English |
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Edition |
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| ISSN |
0960-9822 |
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| Notes |
PMID:23910656; PMCID:PMC4020279 |
Approved |
no |
| Call Number |
LoNNe @ christopher.kyba @ |
Serial |
505 |
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| Author |
Wright, K.P.J.; Hull, J.T.; Czeisler, C.A. |
| Title |
Relationship between alertness, performance, and body temperature in humans |
Type |
Journal Article |
| Year |
2002 |
Publication |
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology |
Abbreviated Journal |
Am J Physiol Regul Integr Comp Physiol |
| Volume |
283 |
Issue |
6 |
Pages |
R1370-7 |
| Keywords |
Human Health; Adult; Attention/*physiology; *Body Temperature; Circadian Rhythm/physiology; Cognition/*physiology; Female; Humans; Male; Memory/physiology; Reaction Time; Sleep/physiology; Time Factors; Wakefulness/physiology; NASA Discipline Regulatory Physiology; Non-NASA Center |
| Abstract |
Body temperature has been reported to influence human performance. Performance is reported to be better when body temperature is high/near its circadian peak and worse when body temperature is low/near its circadian minimum. We assessed whether this relationship between performance and body temperature reflects the regulation of both the internal biological timekeeping system and/or the influence of body temperature on performance independent of circadian phase. Fourteen subjects participated in a forced desynchrony protocol allowing assessment of the relationship between body temperature and performance while controlling for circadian phase and hours awake. Most neurobehavioral measures varied as a function of internal biological time and duration of wakefulness. A number of performance measures were better when body temperature was elevated, including working memory, subjective alertness, visual attention, and the slowest 10% of reaction times. These findings demonstrate that an increased body temperature, associated with and independent of internal biological time, is correlated with improved performance and alertness. These results support the hypothesis that body temperature modulates neurobehavioral function in humans. |
| Address |
Division of Sleep Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. kenneth.wright@colorado.edu |
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English |
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Series Issue |
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Edition |
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| ISSN |
0363-6119 |
ISBN |
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Conference |
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| Notes |
PMID:12388468 |
Approved |
no |
| Call Number |
LoNNe @ kagoburian @ |
Serial |
835 |
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| Author |
Wood, B.; Rea, M.S.; Plitnick, B.; Figueiro, M.G. |
| Title |
Light level and duration of exposure determine the impact of self-luminous tablets on melatonin suppression |
Type |
Journal Article |
| Year |
2013 |
Publication |
Applied Ergonomics |
Abbreviated Journal |
Appl Ergon |
| Volume |
44 |
Issue |
2 |
Pages |
237-240 |
| Keywords |
Adolescent; *Computers, Handheld; Female; Humans; Light/*adverse effects; Male; Melatonin/*biosynthesis; Photoperiod; Saliva/*metabolism; Sleep/radiation effects; Time Factors; Young Adult; melatonin |
| Abstract |
Exposure to light from self-luminous displays may be linked to increased risk for sleep disorders because these devices emit optical radiation at short wavelengths, close to the peak sensitivity of melatonin suppression. Thirteen participants experienced three experimental conditions in a within-subjects design to investigate the impact of self-luminous tablet displays on nocturnal melatonin suppression: 1) tablets-only set to the highest brightness, 2) tablets viewed through clear-lens goggles equipped with blue light-emitting diodes that provided 40 lux of 470-nm light at the cornea, and 3) tablets viewed through orange-tinted glasses (dark control; optical radiation <525 nm approximately 0). Melatonin suppressions after 1-h and 2-h exposures to tablets viewed with the blue light were significantly greater than zero. Suppression levels after 1-h exposure to the tablets-only were not statistically different than zero; however, this difference reached significance after 2 h. Based on these results, display manufacturers can determine how their products will affect melatonin levels and use model predictions to tune the spectral power distribution of self-luminous devices to increase or to decrease stimulation to the circadian system. |
| Address |
Lighting Research Center, Rensselaer Polytechnic Institute, 21 Union Street, Troy, NY 12180, USA. woodb5@rpi.edu |
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English |
Summary Language |
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Series Issue |
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Edition |
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| ISSN |
0003-6870 |
ISBN |
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Conference |
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| Notes |
PMID:22850476 |
Approved |
no |
| Call Number |
IDA @ john @ |
Serial |
136 |
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| Author |
Wilhelm, I.; Born, J.; Kudielka, B.M.; Schlotz, W.; Wust, S. |
| Title |
Is the cortisol awakening rise a response to awakening? |
Type |
Journal Article |
| Year |
2007 |
Publication |
Psychoneuroendocrinology |
Abbreviated Journal |
Psychoneuroendocrinology |
| Volume |
32 |
Issue |
4 |
Pages |
358-366 |
| Keywords |
Human Health; Adrenocorticotropic Hormone/blood; Adult; Arousal/*physiology; Circadian Rhythm; Humans; Hydrocortisone/blood/*metabolism; Hypothalamo-Hypophyseal System/physiology; Male; Pituitary-Adrenal System/physiology; Saliva/chemistry; Sleep/physiology |
| Abstract |
A distinct rise in cortisol levels that occurs after morning awakening is increasingly used as an indicator of adrenocortical activity which is associated with different pathologies. Although it was previously assumed that the transition from sleep to wake is essential for the occurrence of the cortisol morning rise, this has never been tested. Here, we examined 16 healthy young men (20-33 yrs) between 2300 and 0800 h under sleep laboratory conditions. Serum cortisol and plasma adrenocorticotropin (ACTH) as well as salivary cortisol levels (after subjects were woken up at 0700 h) were repeatedly assessed. In a supplementary study condition, salivary cortisol levels in the first hour after awakening were measured at the subjects' home on two consecutive days. Comparison of pre- and post awakening measurements revealed significantly steeper increases in cortisol and ACTH after awakening. The rise in cortisol upon awakening under laboratory conditions did not significantly differ from that observed at home. We conclude that the cortisol increase after awakening is a response to morning awakening that is distinct from the circadian rise in hypothalamo-pituitary-adrenal (HPA) activity in the morning hours. Although the cortisol awakening response is modulated by circadian influences, it primarily reflects phasic psychophysiological processes specific to the sleep-wake transition. |
| Address |
Department of Psychobiology, University of Trier, Johanniterufer 15, 54290 Trier, Germany |
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English |
Summary Language |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
0306-4530 |
ISBN |
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Expedition |
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Conference |
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| Notes |
PMID:17408865 |
Approved |
no |
| Call Number |
LoNNe @ kagoburian @ |
Serial |
834 |
| Permanent link to this record |
