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Author (up) Foster, R.G.; Roenneberg, T. url  doi
openurl 
  Title Human responses to the geophysical daily, annual and lunar cycles Type Journal Article
  Year 2008 Publication Current Biology : CB Abbreviated Journal Curr Biol  
  Volume 18 Issue 17 Pages R784-R794  
  Keywords Human Health; Biological Clocks; Birth Rate; Circadian Rhythm; Death; Female; Human Activities; Humans; Male; Moon; *Periodicity; Photoperiod; Seasons; Sexual Behavior; Sleep  
  Abstract Collectively the daily, seasonal, lunar and tidal geophysical cycles regulate much of the temporal biology of life on Earth. The increasing isolation of human societies from these geophysical cycles, as a result of improved living conditions, high-quality nutrition and 24/7 working practices, have led many to believe that human biology functions independently of them. Yet recent studies have highlighted the dominant role that our circadian clock plays in the organisation of 24 hour patterns of behaviour and physiology. Preferred wake and sleep times are to a large extent driven by an endogenous temporal program that uses sunlight as an entraining cue. The alarm clock can drive human activity rhythms but has little direct effect on our endogenous 24 hour physiology. In many situations, our biology and our society appear to be in serious opposition, and the damaging consequences to our health under these circumstances are increasingly recognised. The seasons dominate the lives of non-equatorial species, and until recently, they also had a marked influence on much of human biology. Despite human isolation from seasonal changes in temperature, food and photoperiod in the industrialised nations, the seasons still appear to have a small, but significant, impact upon when individuals are born and many aspects of health. The seasonal changes that modulate our biology, and how these factors might interact with the social and metabolic status of the individual to drive seasonal effects, are still poorly understood. Lunar cycles had, and continue to have, an influence upon human culture, though despite a persistent belief that our mental health and other behaviours are modulated by the phase of the moon, there is no solid evidence that human biology is in any way regulated by the lunar cycle.  
  Address Circadian and Visual Neuroscience, Nuffield Laboratory of Ophthalmology, University of Oxford, Levels 5 & 6 West Wing, John Radcliffe Hospital, Headley Way, Oxford OX3 7BN, UK. russell.foster@eye.ox.ac.uk  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
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  Series Volume Series Issue Edition  
  ISSN 0960-9822 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:18786384 Approved no  
  Call Number LoNNe @ kagoburian @ Serial 752  
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Author (up) Fritschi, L.; Erren, T.C.; Glass, D.C.; Girschik, J.; Thomson, A.K.; Saunders, C.; Boyle, T.; El-Zaemey, S.; Rogers, P.; Peters, S.; Slevin, T.; D'Orsogna, A.; de Vocht, F.; Vermeulen, R.; Heyworth, J.S. url  doi
openurl 
  Title The association between different night shiftwork factors and breast cancer: a case-control study Type Journal Article
  Year 2013 Publication British Journal of Cancer Abbreviated Journal Br J Cancer  
  Volume 109 Issue 9 Pages 2472-2480  
  Keywords Adult; Aged; Aged, 80 and over; Breast Neoplasms/*epidemiology/etiology; Case-Control Studies; Female; Humans; Life Style; Middle Aged; Questionnaires; Risk; Risk Factors; Western Australia/epidemiology; *Work Schedule Tolerance; Young Adult; oncogenesis  
  Abstract BACKGROUND: Research on the possible association between shiftwork and breast cancer is complicated because there are many different shiftwork factors, which might be involved including: light at night, phase shift, sleep disruption and changes in lifestyle factors while on shiftwork (diet, physical activity, alcohol intake and low sun exposure). METHODS: We conducted a population-based case-control study in Western Australia from 2009 to 2011 with 1205 incident breast cancer cases and 1789 frequency age-matched controls. A self-administered questionnaire was used to collect demographic, reproductive, and lifestyle factors and lifetime occupational history and a telephone interview was used to obtain further details about the shiftwork factors listed above. RESULTS: A small increase in risk was suggested for those ever doing the graveyard shift (work between midnight and 0500 hours) and breast cancer (odds ratio (OR)=1.16, 95% confidence interval (CI)=0.97-1.39). For phase shift, we found a 22% increase in breast cancer risk (OR=1.22, 95% CI=1.01-1.47) with a statistically significant dose-response relationship (P=0.04). For the other shiftwork factors, risks were marginally elevated and not statistically significant. CONCLUSION: We found some evidence that some of the factors involved in shiftwork may be associated with breast cancer but the ORs were low and there were inconsistencies in duration and dose-response relationships.  
  Address Western Australian Institute for Medical Research, The University of Western Australia, Nedlands, Western Australia, Australia  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
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  Series Volume Series Issue Edition  
  ISSN 0007-0920 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:24022188; PMCID:PMC3817316 Approved no  
  Call Number IDA @ john @ Serial 153  
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Author (up) Gooley, J.J.; Chamberlain, K.; Smith, K.A.; Khalsa, S.B.S.; Rajaratnam, S.M.W.; Van Reen, E.; Zeitzer, J.M.; Czeisler, C.A.; Lockley, S.W. url  doi
openurl 
  Title Exposure to room light before bedtime suppresses melatonin onset and shortens melatonin duration in humans Type Journal Article
  Year 2011 Publication The Journal of Clinical Endocrinology and Metabolism Abbreviated Journal J Clin Endocrinol Metab  
  Volume 96 Issue 3 Pages E463-72  
  Keywords Adolescent; Adult; Female; Humans; *Light; *Lighting; Male; Melatonin/*blood; Sleep/physiology; Time Factors; Young Adult  
  Abstract CONTEXT: Millions of individuals habitually expose themselves to room light in the hours before bedtime, yet the effects of this behavior on melatonin signaling are not well recognized. OBJECTIVE: We tested the hypothesis that exposure to room light in the late evening suppresses the onset of melatonin synthesis and shortens the duration of melatonin production. DESIGN: In a retrospective analysis, we compared daily melatonin profiles in individuals living in room light (<200 lux) vs. dim light (<3 lux). PATIENTS: Healthy volunteers (n = 116, 18-30 yr) were recruited from the general population to participate in one of two studies. SETTING: Participants lived in a General Clinical Research Center for at least five consecutive days. INTERVENTION: Individuals were exposed to room light or dim light in the 8 h preceding bedtime. OUTCOME MEASURES: Melatonin duration, onset and offset, suppression, and phase angle of entrainment were determined. RESULTS: Compared with dim light, exposure to room light before bedtime suppressed melatonin, resulting in a later melatonin onset in 99.0% of individuals and shortening melatonin duration by about 90 min. Also, exposure to room light during the usual hours of sleep suppressed melatonin by greater than 50% in most (85%) trials. CONCLUSIONS: These findings indicate that room light exerts a profound suppressive effect on melatonin levels and shortens the body's internal representation of night duration. Hence, chronically exposing oneself to electrical lighting in the late evening disrupts melatonin signaling and could therefore potentially impact sleep, thermoregulation, blood pressure, and glucose homeostasis.  
  Address Division of Sleep Medicine, Brigham and Women's Hospital and Harvard Medical School, 221 Longwood Avenue, Boston, Massachusetts 02115, USA. gmsjjg@nus.edu  
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  Series Volume Series Issue Edition  
  ISSN 0021-972X ISBN Medium  
  Area Expedition Conference  
  Notes PMID:21193540; PMCID:PMC3047226 Approved no  
  Call Number IDA @ john @ Serial 139  
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Author (up) Grundy, A.; Richardson, H.; Burstyn, I.; Lohrisch, C.; SenGupta, S.K.; Lai, A.S.; Lee, D.; Spinelli, J.J.; Aronson, K.J. url  doi
openurl 
  Title Increased risk of breast cancer associated with long-term shift work in Canada Type Journal Article
  Year 2013 Publication Occupational and Environmental Medicine Abbreviated Journal Occup Environ Med  
  Volume 70 Issue 12 Pages 831-838  
  Keywords Human Health; Adult; Aged; Aged, 80 and over; Breast Neoplasms/epidemiology/*etiology/metabolism; British Columbia/epidemiology; Case-Control Studies; Female; Humans; Menopause; Middle Aged; Occupational Diseases/*epidemiology; Ontario/epidemiology; Receptors, Estrogen/metabolism; Receptors, Progesterone/metabolism; Risk Factors; Tumor Markers, Biological/metabolism; Work Schedule Tolerance/*physiology; Young Adult  
  Abstract OBJECTIVES: Long-term night work has been suggested as a risk factor for breast cancer; however, additional studies with more comprehensive methods of exposure assessment to capture the diversity of shift patterns are needed. As well, few previous studies have considered the role of hormone receptor subtype. METHODS: Relationships between night shift work and breast cancer were examined among 1134 breast cancer cases and 1179 controls, frequency-matched by age in Vancouver, British Columbia, and Kingston, Ontario. Self-reported lifetime occupational histories were assessed for night shift work, and hormone receptor status obtained from tumour pathology records. RESULTS: With approximately one-third of cases and controls ever employed in night shift work, associations with duration demonstrated no relationship between either 0-14 or 15-29 years, while an association was apparent for >/=30 years (OR=2.21, 95% CI 1.14 to 4.31). This association with long-term night shift work is robust to alternative definitions of prolonged shift work, with similar results for both health and non-health care workers. CONCLUSIONS: Long-term night shift work in a diverse mix of occupations is associated with increased breast cancer risk and not limited to nurses, as in most previous studies.  
  Address Department of Public Health Sciences and Queen's Cancer Research Institute, Queen's University, Kingston, Ontario, Canada  
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  Language English Summary Language Original Title  
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  Series Volume Series Issue Edition  
  ISSN 1351-0711 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:23817841 Approved no  
  Call Number LoNNe @ kagoburian @ Serial 757  
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Author (up) Hansen, J.; Lassen, C.F. url  doi
openurl 
  Title Nested case-control study of night shift work and breast cancer risk among women in the Danish military Type Journal Article
  Year 2012 Publication Occupational and Environmental Medicine Abbreviated Journal Occup Environ Med  
  Volume 69 Issue 8 Pages 551-556  
  Keywords Adult; Aged; Aged, 80 and over; Breast Neoplasms/*etiology; Case-Control Studies; *Circadian Rhythm; Denmark/epidemiology; Female; Humans; Logistic Models; Middle Aged; Military Personnel; *Occupations; Odds Ratio; Risk Factors; *Sunlight; *Work; *Work Schedule Tolerance; oncogenesis  
  Abstract OBJECTIVES: Growing but limited evidence suggests that night shift work is associated with breast cancer. The authors conducted a nationwide case-control study nested within a cohort of 18,551 female military employees born in 1929-1968 to investigate the risk for breast cancer after night shift work and to explore the role of leisure time sun exposure and diurnal preference. METHODS: The authors documented 218 cases of breast cancer (1990-2003) and selected 899 age-matched controls from the cohort by incidence density sampling. Information on shift work, sun exposure habits, diurnal preference and other potential confounders was obtained from a structured questionnaire. ORs were estimated by multivariate conditional logistic regression. RESULTS: Overall, the authors observed an adjusted OR of 1.4 (95% CI 0.9 to 2.1) among women with ever compared with never night shifts. The RR for breast cancer tended to increase with increasing number of years of night shift work (p=0.03) and with cumulative number of shifts (p=0.02),with a neutral risk for fewer than three night shifts per week. The OR for the group with the highest tertile of cumulative exposure was 2.3 (95% CI 1.2 to 4.6). The most pronounced effect of night shift work on breast cancer risk was observed in women with morning chronotype preference and intense night shifts (OR=3.9, 95% CI 1.6 to 9.5). Night shift workers tended to sunbathe more frequently than day workers. CONCLUSIONS: The results indicate that frequent night shift work increases the risk for breast cancer and suggest a higher risk with longer duration of intense night shifts. Women with morning preference who worked on night shifts tended to have a higher risk than those with evening preference.  
  Address Institute of Cancer Epidemiology, Danish Cancer Society, Strandboulevarden 49, Copenhagen DK2100, Denmark. johnni@cancer.dk  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1351-0711 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:22645325 Approved no  
  Call Number IDA @ john @ Serial 156  
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