| Records |
| Author |
Sherman, H.; Gutman, R.; Chapnik, N.; Meylan, J.; le Coutre, J.; Froy, O. |
| Title |
Caffeine alters circadian rhythms and expression of disease and metabolic markers |
Type |
Journal Article |
| Year |
2011 |
Publication |
The International Journal of Biochemistry & Cell Biology |
Abbreviated Journal |
Int J Biochem Cell Biol |
| Volume |
43 |
Issue |
5 |
Pages  |
829-838 |
| Keywords |
Human Health; Animals; Biological Markers/blood/metabolism; Body Weight/drug effects/physiology; Caffeine/*pharmacology; Caloric Restriction; Circadian Rhythm/*drug effects/genetics/physiology; *Disease/genetics; Eating/drug effects/physiology; Gene Expression Regulation/*drug effects/genetics; HEK293 Cells; Humans; Inflammation/metabolism; Male; Mice; Mice, Inbred C57BL; Motor Activity/drug effects/physiology |
| Abstract |
The circadian clock regulates many aspects of physiology, energy metabolism, and sleep. Restricted feeding (RF), a regimen that restricts the duration of food availability entrains the circadian clock. Caffeine has been shown to affect both metabolism and sleep. However, its effect on clock gene and clock-controlled gene expression has not been studied. Here, we tested the effect of caffeine on circadian rhythms and the expression of disease and metabolic markers in the serum, liver, and jejunum of mice supplemented with caffeine under ad libitum (AL) feeding or RF for 16 weeks. Caffeine significantly affected circadian oscillation and the daily levels of disease and metabolic markers. Under AL, caffeine reduced the average daily mRNA levels of certain disease and inflammatory markers, such as liver alpha fetoprotein (Afp), C-reactive protein (Crp), jejunum alanine aminotransferase (Alt), growth arrest and DNA damage 45beta (Gadd45beta), Interleukin 1alpha (Il-1alpha), Il-1beta mRNA and serum plasminogen activator inhibitor 1 (PAI-1). Under RF, caffeine reduced the average daily levels of Alt, Gadd45beta, Il-1alpha and Il-1beta mRNA in the jejunum, but not in the liver. In addition, caffeine supplementation led to decreased expression of catabolic factors under RF. In conclusion, caffeine affects circadian gene expression and metabolism possibly leading to beneficial effects mainly under AL feeding. |
| Address |
Institute of Biochemistry, Food Science and Nutrition, Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 76100, Israel |
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| Language |
English |
Summary Language |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
1357-2725 |
ISBN |
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Medium |
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Expedition |
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Conference |
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| Notes |
PMID:21352949 |
Approved |
no |
| Call Number |
LoNNe @ kagoburian @ |
Serial |
810 |
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| Author |
Foster, R.G.; Roenneberg, T. |
| Title |
Human responses to the geophysical daily, annual and lunar cycles |
Type |
Journal Article |
| Year |
2008 |
Publication |
Current Biology : CB |
Abbreviated Journal |
Curr Biol |
| Volume |
18 |
Issue |
17 |
Pages |
R784-R794 |
| Keywords |
Human Health; Biological Clocks; Birth Rate; Circadian Rhythm; Death; Female; Human Activities; Humans; Male; Moon; *Periodicity; Photoperiod; Seasons; Sexual Behavior; Sleep |
| Abstract |
Collectively the daily, seasonal, lunar and tidal geophysical cycles regulate much of the temporal biology of life on Earth. The increasing isolation of human societies from these geophysical cycles, as a result of improved living conditions, high-quality nutrition and 24/7 working practices, have led many to believe that human biology functions independently of them. Yet recent studies have highlighted the dominant role that our circadian clock plays in the organisation of 24 hour patterns of behaviour and physiology. Preferred wake and sleep times are to a large extent driven by an endogenous temporal program that uses sunlight as an entraining cue. The alarm clock can drive human activity rhythms but has little direct effect on our endogenous 24 hour physiology. In many situations, our biology and our society appear to be in serious opposition, and the damaging consequences to our health under these circumstances are increasingly recognised. The seasons dominate the lives of non-equatorial species, and until recently, they also had a marked influence on much of human biology. Despite human isolation from seasonal changes in temperature, food and photoperiod in the industrialised nations, the seasons still appear to have a small, but significant, impact upon when individuals are born and many aspects of health. The seasonal changes that modulate our biology, and how these factors might interact with the social and metabolic status of the individual to drive seasonal effects, are still poorly understood. Lunar cycles had, and continue to have, an influence upon human culture, though despite a persistent belief that our mental health and other behaviours are modulated by the phase of the moon, there is no solid evidence that human biology is in any way regulated by the lunar cycle. |
| Address |
Circadian and Visual Neuroscience, Nuffield Laboratory of Ophthalmology, University of Oxford, Levels 5 & 6 West Wing, John Radcliffe Hospital, Headley Way, Oxford OX3 7BN, UK. russell.foster@eye.ox.ac.uk |
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English |
Summary Language |
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Abbreviated Series Title |
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Edition |
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| ISSN |
0960-9822 |
ISBN |
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Conference |
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| Notes |
PMID:18786384 |
Approved |
no |
| Call Number |
LoNNe @ kagoburian @ |
Serial |
752 |
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| Author |
Bhatti, P.; Mirick, D.K.; Davis, S. |
| Title |
Invited commentary: Shift work and cancer |
Type |
Journal Article |
| Year |
2012 |
Publication |
American Journal of Epidemiology |
Abbreviated Journal |
Am J Epidemiol |
| Volume |
176 |
Issue |
9 |
Pages |
760-3; discussion 764-5 |
| Keywords |
Human Health; Circadian Rhythm; Humans; Male; *Men's Health; Neoplasms/*epidemiology; Occupations/*statistics & numerical data; Personnel Staffing and Scheduling/*statistics & numerical data |
| Abstract |
In this issue of the Journal, Parent et al. (Am J Epidemiol. 2012;176(9):751-759) report significant associations between night-shift work and risk of cancer at several sites among men. These findings not only address the need for shift-work studies that evaluate cancers other than breast and prostate cancer but also support the increasing concern that the negative effects of shift work may be broadly applicable to risk of many cancers via the direct oncostatic properties of melatonin. Studies of shift work have been limited by a lack of detailed data for determining which aspects of this multifaceted exposure may be associated with increased cancer risk. Additionally, the influence of individual-level characteristics, such as preference for daytime activity versus nighttime activity or chronotype, has not been considered. In moving forward, launching new cohort studies of shift work and cancer risk is the most tenable approach, though it will be limited by the years of follow-up required in order to accrue adequate numbers of cancer cases. Studies incorporating biomarkers of effect are useful for providing immediate information that can aid not only in identifying the underlying mechanisms of the shift-work-cancer association but also in interpreting existing epidemiologic data and informing the design of future epidemiologic studies of cancer risk. |
| Address |
Program in Epidemiology, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA. pbhatti@fhcrc.org |
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English |
Summary Language |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
0002-9262 |
ISBN |
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Medium |
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Expedition |
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Conference |
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| Notes |
PMID:23035018 |
Approved |
no |
| Call Number |
LoNNe @ christopher.kyba @ |
Serial |
507 |
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| Author |
Parent, M.-E.; El-Zein, M.; Rousseau, M.-C.; Pintos, J.; Siemiatycki, J. |
| Title |
Night work and the risk of cancer among men |
Type |
Journal Article |
| Year |
2012 |
Publication |
American Journal of Epidemiology |
Abbreviated Journal |
Am J Epidemiol |
| Volume |
176 |
Issue |
9 |
Pages |
751-759 |
| Keywords |
Adult; Aged; *Circadian Rhythm; Humans; Male; *Men's Health; Middle Aged; Neoplasms/*epidemiology; Occupations/*statistics & numerical data; Personnel Staffing and Scheduling/*statistics & numerical data; Quebec/epidemiology; Risk Factors; oncogenesis |
| Abstract |
Night work might influence cancer risk, possibly via suppression of melatonin release. In a population-based case-control study conducted in Montreal, Quebec, Canada, between 1979 and 1985, job histories, including work hours, were elicited from 3,137 males with incident cancer at one of 11 anatomic sites and from 512 controls. Compared with men who never worked at night, the adjusted odds ratios among men who ever worked at night were 1.76 (95% confidence interval (CI): 1.25, 2.47) for lung cancer, 2.03 (95% CI: 1.43, 2.89) for colon cancer, 1.74 (95% CI: 1.22, 2.49) for bladder cancer, 2.77 (95% CI: 1.96, 3.92) for prostate cancer, 2.09 (95% CI: 1.40, 3.14) for rectal cancer, 2.27 (95% CI: 1.24, 4.15) for pancreatic cancer, and 2.31 (95% CI: 1.48, 3.61) for non-Hodgkin's lymphoma. Equivocal evidence or no evidence was observed for cancers of the stomach (odds ratio (OR) = 1.34, 95% CI: 0.85, 2.10), kidney (OR = 1.42, 95% CI: 0.86, 2.35), and esophagus (OR = 1.51, 95% CI: 0.80, 2.84) and for melanoma (OR = 1.04, 95% CI: 0.49, 2.22). There was no evidence of increasing risk with increasing duration of night work, with risks generally being increased across all duration categories. Results suggest that night work may increase cancer risk at several sites among men. |
| Address |
INRS-Institut Armand-Frappier, University of Quebec, Laval, Canada. marie-elise.parent@iaf.inrs.ca |
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English |
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Edition |
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0002-9262 |
ISBN |
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| Notes |
PMID:23035019 |
Approved |
no |
| Call Number |
IDA @ john @ |
Serial |
158 |
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| Author |
Kantermann, T. |
| Title |
Circadian biology: sleep-styles shaped by light-styles |
Type |
Journal Article |
| Year |
2013 |
Publication |
Current Biology : CB |
Abbreviated Journal |
Curr Biol |
| Volume |
23 |
Issue |
16 |
Pages |
R689-90 |
| Keywords |
Human Health; Circadian Clocks/*radiation effects; Female; Humans; *Lighting; Male; *Photoperiod; *Sunlight |
| Abstract |
Light and darkness are the main time cues synchronising all biological clocks to the external environment. This little understood evolutionary phenomenon is called circadian entrainment. A new study illuminates our understanding of how modern light- and lifestyles compromise circadian entrainment and impact our biological clocks. |
| Address |
Chronobiology – Centre for Behaviour and Neurosciences, University of Groningen, Nijenborgh 7, 9747 AG Groningen, The Netherlands. thomas@kantermann.de |
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English |
Summary Language |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
0960-9822 |
ISBN |
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Medium |
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Expedition |
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Conference |
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| Notes |
PMID:23968925 |
Approved |
no |
| Call Number |
LoNNe @ christopher.kyba @ |
Serial |
501 |
| Permanent link to this record |
