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Author Vollmer, C.; Randler, C.; Di Milia, L. url  doi
openurl 
  Title Further evidence for the influence of photoperiod at birth on chronotype in a sample of German adolescents Type Journal Article
  Year 2012 Publication Chronobiology International Abbreviated Journal Chronobiol Int  
  Volume 29 Issue (up) 10 Pages 1345-1351  
  Keywords Human Health; Adolescent; Child; Circadian Rhythm/*physiology; Female; Germany; Humans; Male; Parturition/*physiology; *Photoperiod; Puberty/physiology; *Seasons; Sleep/*physiology  
  Abstract Individuals differ in their circadian preferences (chronotype). There is evidence in the literature to support a season-of-birth effect on chronotype but the evidence is not convincing. In part, the relationship is obscured by a number of methodological differences between studies, including the measures used to define morningness, the way in which the seasons were categorized, and the sample size. This study adds to the literature in several ways. First, we adopt a new approach to categorizing the photoperiod rather than the calendar season; thus we prefer to use the term photoperiod at birth. Second, we used two measures of morningness. Third, we used a large and homogeneous German sample. The results show that adolescents (n = 2905) born during the increasing photoperiod (Feb-Apr) had a significantly later midpoint of sleep (MSFsc) than those born during the decreasing photoperiod (Aug-Oct). A similar pattern was found for the Composite Scale of Morningness (CSM). Furthermore, both measures of chronotype demonstrated a significant quadratic function over a 1-yr cycle. When looking at each of six consecutive years separately, the Composite Scale of Morningness suggests a cosine rhythm linked to increasing and decreasing photoperiods that becomes weaker in amplitude with increasing age. Despite the strengths in our study, the effect of photoperiod at birth on chronotype remains small. Future studies may require larger sample sizes, may need to explore how neonatal light exposure modulates chronotype, and may need to track how puberty and adolescent lifestyle habits mask the photoperiod effect.  
  Address Department of Biology, University of Education Heidelberg, Im Neuenheimer Feld 561-2, Heidelberg, Germany. vollmer@ph-heidelberg.de  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0742-0528 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:23130997 Approved no  
  Call Number LoNNe @ christopher.kyba @ Serial 517  
Permanent link to this record
 

 
Author Orbach, D.N.; Fenton, B. url  doi
openurl 
  Title Vision impairs the abilities of bats to avoid colliding with stationary obstacles Type Journal Article
  Year 2010 Publication PloS one Abbreviated Journal PLoS One  
  Volume 5 Issue (up) 11 Pages e13912  
  Keywords Analysis of Variance; Animals; Chiroptera/*physiology; Cyclonic Storms; Echolocation/*physiology; Female; Flight, Animal/*physiology; Light; Male; Space Perception/physiology/radiation effects; Vision, Ocular/*physiology/radiation effects; Vocalization, Animal/physiology  
  Abstract BACKGROUND: Free-flying insectivorous bats occasionally collide with stationary objects they should easily detect by echolocation and avoid. Collisions often occur with lighted objects, suggesting ambient light may deleteriously affect obstacle avoidance capabilities. We tested the hypothesis that free-flying bats may orient by vision when they collide with some obstacles. We additionally tested whether acoustic distractions, such as “distress calls” of other bats, contributed to probabilities of collision. METHODOLOGY/PRINCIPAL FINDINGS: To investigate the role of visual cues in the collisions of free-flying little brown bats (Myotis lucifugus) with stationary objects, we set up obstacles in an area of high bat traffic during swarming. We used combinations of light intensities and visually dissimilar obstacles to verify that bats orient by vision. In early August, bats collided more often in the light than the dark, and probabilities of collision varied with the visibility of obstacles. However, the probabilities of collisions altered in mid to late August, coincident with the start of behavioural, hormonal, and physiological changes occurring during swarming and mating. Distress calls did not distract bats and increase the incidence of collisions. CONCLUSIONS/SIGNIFICANCE: Our findings indicate that visual cues are more important for free-flying bats than previously recognized, suggesting integration of multi-sensory modalities during orientation. Furthermore, our study highlights differences between responses of captive and wild bats, indicating a need for more field experiments.  
  Address Department of Biology, University of Western Ontario, London, Ontario, Canada. dnorbach@gmail.com  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
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  Series Volume Series Issue Edition  
  ISSN 1932-6203 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:21085481; PMCID:PMC2976695 Approved no  
  Call Number IDA @ john @ Serial 96  
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Author Kloog, I.; Stevens, R.G.; Haim, A.; Portnov, B.A. url  doi
openurl 
  Title Nighttime light level co-distributes with breast cancer incidence worldwide Type Journal Article
  Year 2010 Publication Cancer Causes & Control : CCC Abbreviated Journal Cancer Causes Control  
  Volume 21 Issue (up) 12 Pages 2059-2068  
  Keywords Adult; Birth Rate; Breast Neoplasms/*epidemiology/etiology; Carcinoma/*epidemiology/etiology; Circadian Rhythm/*physiology; Cohort Studies; Electricity; Female; Humans; Incidence; *Light/adverse effects; Lighting; Photoperiod; Registries; Urban Population/statistics & numerical data; World Health; oncogenesis  
  Abstract Breast cancer incidence varies widely among countries of the world for largely unknown reasons. We investigated whether country-level light at night (LAN) is associated with incidence. We compared incidence rates of five common cancers in women (breast, lung, colorectal, larynx, and liver), observed in 164 countries of the world from the GLOBOCAN database, with population-weighted country-level LAN, and with several developmental and environmental indicators, including fertility rate, per capita income, percent of urban population, and electricity consumption. Two types of regression models were used in the analysis: Ordinary Least Squares and Spatial Errors. We found a significant positive association between population LAN level and incidence rates of breast cancer. There was no such an association between LAN level and colorectal, larynx, liver, and lung cancers. A sensitivity test, holding other variables at their average values, yielded a 30-50% higher risk of breast cancer in the highest LAN exposed countries compared to the lowest LAN exposed countries. The possibility that under-reporting from the registries in the low-resource, and also low-LAN, countries created a spurious association was evaluated in several ways and shown not to account for the results. These findings provide coherence of the previously reported case-control and cohort studies with the co-distribution of LAN and breast cancer in entire populations.  
  Address Department of Natural Resources & Environmental Management, University of Haifa, 31905 Mount Carmel, Haifa, Israel  
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  Language English Summary Language Original Title  
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  Series Volume Series Issue Edition  
  ISSN 0957-5243 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:20680434 Approved no  
  Call Number IDA @ john @ Serial 160  
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Author Li, Q.; Zheng, T.; Holford, T.R.; Boyle, P.; Zhang, Y.; Dai, M. url  doi
openurl 
  Title Light at night and breast cancer risk: results from a population-based case-control study in Connecticut, USA Type Journal Article
  Year 2010 Publication Cancer Causes & Control : CCC Abbreviated Journal Cancer Causes Control  
  Volume 21 Issue (up) 12 Pages 2281-2285  
  Keywords Adult; Aged; Aged, 80 and over; Breast Neoplasms/epidemiology/*etiology; Carcinoma/epidemiology/*etiology; Case-Control Studies; Circadian Rhythm/physiology; Connecticut/epidemiology; Female; Humans; *Light/adverse effects; Middle Aged; Population; Questionnaires; Risk Factors; United States/epidemiology; Work Schedule Tolerance/physiology; Oncogenesis  
  Abstract OBJECTIVE: To investigate the potential association between domestic exposure to light at night (LAN) and the risk of human breast cancer. METHODS: A case-control study of female breast cancer was conducted in Connecticut. A total of 363 incident breast cancer cases and 356 age frequency-matched controls were interviewed using a standardized, structured questionnaire to obtain information on sleeping patterns and bedroom light environment. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by unconditional multivariate logistic regression. RESULTS: A non-significantly increased risk of breast cancer was observed among postmenopausal women for those keeping lights on while sleeping (OR = 1.4, 95% CI 0.7, 2.7), those who reported mainly sleeping in the daytime (OR = 1.4, 95% CI 0.5, 4.3), and those not drawing the curtains/window shades while sleeping at night (OR = 1.2, 95% CI 0.8, 1.9). CONCLUSION: The results from this study suggest a potential increased risk of breast cancer associated with domestic exposure to LAN. Further studies with larger sample size are needed to confirm the results.  
  Address Department of Social Medicine, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0957-5243 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:20927578; PMCID:PMC3154700 Approved no  
  Call Number IDA @ john @ Serial 161  
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Author Yasuniwa, Y.; Izumi, H.; Wang, K.-Y.; Shimajiri, S.; Sasaguri, Y.; Kawai, K.; Kasai, H.; Shimada, T.; Miyake, K.; Kashiwagi, E.; Hirano, G.; Kidani, A.; Akiyama, M.; Han, B.; Wu, Y.; Ieiri, I.; Higuchi, S.; Kohno, K. url  doi
openurl 
  Title Circadian disruption accelerates tumor growth and angio/stromagenesis through a Wnt signaling pathway Type Journal Article
  Year 2010 Publication PloS one Abbreviated Journal PLoS One  
  Volume 5 Issue (up) 12 Pages e15330  
  Keywords Animals; *Circadian Rhythm; Disease Progression; *Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Neoplasms/*pathology; *Neovascularization, Pathologic; Nerve Tissue Proteins/metabolism; Skin/metabolism; Vascular Endothelial Growth Factor A/metabolism; Wnt Proteins/*metabolism; Oncogenesis  
  Abstract Epidemiologic studies show a high incidence of cancer in shift workers, suggesting a possible relationship between circadian rhythms and tumorigenesis. However, the precise molecular mechanism played by circadian rhythms in tumor progression is not known. To identify the possible mechanisms underlying tumor progression related to circadian rhythms, we set up nude mouse xenograft models. HeLa cells were injected in nude mice and nude mice were moved to two different cases, one case is exposed to a 24-hour light cycle (L/L), the other is a more “normal” 12-hour light/dark cycle (L/D). We found a significant increase in tumor volume in the L/L group compared with the L/D group. In addition, tumor microvessels and stroma were strongly increased in L/L mice. Although there was a hypervascularization in L/L tumors, there was no associated increase in the production of vascular endothelial cell growth factor (VEGF). DNA microarray analysis showed enhanced expression of WNT10A, and our subsequent study revealed that WNT10A stimulates the growth of both microvascular endothelial cells and fibroblasts in tumors from light-stressed mice, along with marked increases in angio/stromagenesis. Only the tumor stroma stained positive for WNT10A and WNT10A is also highly expressed in keloid dermal fibroblasts but not in normal dermal fibroblasts indicated that WNT10A may be a novel angio/stromagenic growth factor. These findings suggest that circadian disruption induces the progression of malignant tumors via a Wnt signaling pathway.  
  Address Department of Molecular Biology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan  
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  Language English Summary Language Original Title  
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  ISSN 1932-6203 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:21203463; PMCID:PMC3009728 Approved no  
  Call Number IDA @ john @ Serial 162  
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