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Author Fritschi, L.; Erren, T.C.; Glass, D.C.; Girschik, J.; Thomson, A.K.; Saunders, C.; Boyle, T.; El-Zaemey, S.; Rogers, P.; Peters, S.; Slevin, T.; D'Orsogna, A.; de Vocht, F.; Vermeulen, R.; Heyworth, J.S.
Title The association between different night shiftwork factors and breast cancer: a case-control study Type Journal Article
Year 2013 Publication British Journal of Cancer Abbreviated Journal Br J Cancer
Volume 109 Issue 9 Pages 2472-2480
Keywords (up) Adult; Aged; Aged, 80 and over; Breast Neoplasms/*epidemiology/etiology; Case-Control Studies; Female; Humans; Life Style; Middle Aged; Questionnaires; Risk; Risk Factors; Western Australia/epidemiology; *Work Schedule Tolerance; Young Adult; oncogenesis
Abstract BACKGROUND: Research on the possible association between shiftwork and breast cancer is complicated because there are many different shiftwork factors, which might be involved including: light at night, phase shift, sleep disruption and changes in lifestyle factors while on shiftwork (diet, physical activity, alcohol intake and low sun exposure). METHODS: We conducted a population-based case-control study in Western Australia from 2009 to 2011 with 1205 incident breast cancer cases and 1789 frequency age-matched controls. A self-administered questionnaire was used to collect demographic, reproductive, and lifestyle factors and lifetime occupational history and a telephone interview was used to obtain further details about the shiftwork factors listed above. RESULTS: A small increase in risk was suggested for those ever doing the graveyard shift (work between midnight and 0500 hours) and breast cancer (odds ratio (OR)=1.16, 95% confidence interval (CI)=0.97-1.39). For phase shift, we found a 22% increase in breast cancer risk (OR=1.22, 95% CI=1.01-1.47) with a statistically significant dose-response relationship (P=0.04). For the other shiftwork factors, risks were marginally elevated and not statistically significant. CONCLUSION: We found some evidence that some of the factors involved in shiftwork may be associated with breast cancer but the ORs were low and there were inconsistencies in duration and dose-response relationships.
Address Western Australian Institute for Medical Research, The University of Western Australia, Nedlands, Western Australia, Australia
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0007-0920 ISBN Medium
Area Expedition Conference
Notes PMID:24022188; PMCID:PMC3817316 Approved no
Call Number IDA @ john @ Serial 153
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Author Hansen, J.; Lassen, C.F.
Title Nested case-control study of night shift work and breast cancer risk among women in the Danish military Type Journal Article
Year 2012 Publication Occupational and Environmental Medicine Abbreviated Journal Occup Environ Med
Volume 69 Issue 8 Pages 551-556
Keywords (up) Adult; Aged; Aged, 80 and over; Breast Neoplasms/*etiology; Case-Control Studies; *Circadian Rhythm; Denmark/epidemiology; Female; Humans; Logistic Models; Middle Aged; Military Personnel; *Occupations; Odds Ratio; Risk Factors; *Sunlight; *Work; *Work Schedule Tolerance; oncogenesis
Abstract OBJECTIVES: Growing but limited evidence suggests that night shift work is associated with breast cancer. The authors conducted a nationwide case-control study nested within a cohort of 18,551 female military employees born in 1929-1968 to investigate the risk for breast cancer after night shift work and to explore the role of leisure time sun exposure and diurnal preference. METHODS: The authors documented 218 cases of breast cancer (1990-2003) and selected 899 age-matched controls from the cohort by incidence density sampling. Information on shift work, sun exposure habits, diurnal preference and other potential confounders was obtained from a structured questionnaire. ORs were estimated by multivariate conditional logistic regression. RESULTS: Overall, the authors observed an adjusted OR of 1.4 (95% CI 0.9 to 2.1) among women with ever compared with never night shifts. The RR for breast cancer tended to increase with increasing number of years of night shift work (p=0.03) and with cumulative number of shifts (p=0.02),with a neutral risk for fewer than three night shifts per week. The OR for the group with the highest tertile of cumulative exposure was 2.3 (95% CI 1.2 to 4.6). The most pronounced effect of night shift work on breast cancer risk was observed in women with morning chronotype preference and intense night shifts (OR=3.9, 95% CI 1.6 to 9.5). Night shift workers tended to sunbathe more frequently than day workers. CONCLUSIONS: The results indicate that frequent night shift work increases the risk for breast cancer and suggest a higher risk with longer duration of intense night shifts. Women with morning preference who worked on night shifts tended to have a higher risk than those with evening preference.
Address Institute of Cancer Epidemiology, Danish Cancer Society, Strandboulevarden 49, Copenhagen DK2100, Denmark. johnni@cancer.dk
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1351-0711 ISBN Medium
Area Expedition Conference
Notes PMID:22645325 Approved no
Call Number IDA @ john @ Serial 156
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Author Li, Q.; Zheng, T.; Holford, T.R.; Boyle, P.; Zhang, Y.; Dai, M.
Title Light at night and breast cancer risk: results from a population-based case-control study in Connecticut, USA Type Journal Article
Year 2010 Publication Cancer Causes & Control : CCC Abbreviated Journal Cancer Causes Control
Volume 21 Issue 12 Pages 2281-2285
Keywords (up) Adult; Aged; Aged, 80 and over; Breast Neoplasms/epidemiology/*etiology; Carcinoma/epidemiology/*etiology; Case-Control Studies; Circadian Rhythm/physiology; Connecticut/epidemiology; Female; Humans; *Light/adverse effects; Middle Aged; Population; Questionnaires; Risk Factors; United States/epidemiology; Work Schedule Tolerance/physiology; Oncogenesis
Abstract OBJECTIVE: To investigate the potential association between domestic exposure to light at night (LAN) and the risk of human breast cancer. METHODS: A case-control study of female breast cancer was conducted in Connecticut. A total of 363 incident breast cancer cases and 356 age frequency-matched controls were interviewed using a standardized, structured questionnaire to obtain information on sleeping patterns and bedroom light environment. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by unconditional multivariate logistic regression. RESULTS: A non-significantly increased risk of breast cancer was observed among postmenopausal women for those keeping lights on while sleeping (OR = 1.4, 95% CI 0.7, 2.7), those who reported mainly sleeping in the daytime (OR = 1.4, 95% CI 0.5, 4.3), and those not drawing the curtains/window shades while sleeping at night (OR = 1.2, 95% CI 0.8, 1.9). CONCLUSION: The results from this study suggest a potential increased risk of breast cancer associated with domestic exposure to LAN. Further studies with larger sample size are needed to confirm the results.
Address Department of Social Medicine, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0957-5243 ISBN Medium
Area Expedition Conference
Notes PMID:20927578; PMCID:PMC3154700 Approved no
Call Number IDA @ john @ Serial 161
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Author Knutsson, A.; Alfredsson, L.; Karlsson, B.; Akerstedt, T.; Fransson, E.I.; Westerholm, P.; Westerlund, H.
Title Breast cancer among shift workers: results of the WOLF longitudinal cohort study Type Journal Article
Year 2013 Publication Scandinavian Journal of Work, Environment & Health Abbreviated Journal Scand J Work Environ Health
Volume 39 Issue 2 Pages 170-177
Keywords (up) Adult; Aged; Breast Neoplasms/*epidemiology/etiology; Circadian Rhythm; Female; Humans; Incidence; Longitudinal Studies; Middle Aged; Proportional Hazards Models; Risk Assessment; Sweden/epidemiology; *Work Schedule Tolerance; oncogenesis
Abstract OBJECTIVE: The aim of this study was to investigate whether shift work (with or without night work) is associated with increased risk of breast cancer. METHODS: The population consisted of 4036 women. Data were obtained from WOLF (Work, Lipids, and Fibrinogen), a longitudinal cohort study. Information about baseline characteristics was based on questionnaire responses and medical examination. Cancer incidence from baseline to follow-up was obtained from the national cancer registry. Two exposure groups were identified: shift work with and without night work. The group with day work only was used as the reference group in the analysis. Cox regression analysis was used to calculate relative risk. RESULTS: In total, 94 women developed breast cancer during follow-up. The average follow-up time was 12.4 years. The hazard ratio for breast cancer was 1.23 [95% confidence interval (95% CI) 0.70-2.17] for shifts without night work and 2.02 (95% CI 1.03-3.95) for shifts with night work. When including only women <60 years of age, the risk estimates were 1.18 (95% CI 0.67-2.07) for shifts without night work, and 2.15 (95% CI 1.10-4.21) for shifts with night work. CONCLUSIONS: Our results indicate an increased risk for breast cancer among women who work shifts that includes night work.
Address Department of Health Sciences, Mid Sweden University, Sundsvall. Sweden. Anders.Knutsson@miun.se
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0355-3140 ISBN Medium
Area Expedition Conference
Notes PMID:23007867 Approved no
Call Number IDA @ john @ Serial 154
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Author Cajochen, C.; Altanay-Ekici, S.; Munch, M.; Frey, S.; Knoblauch, V.; Wirz-Justice, A.
Title Evidence that the lunar cycle influences human sleep Type Journal Article
Year 2013 Publication Current Biology : CB Abbreviated Journal Curr Biol
Volume 23 Issue 15 Pages 1485-1488
Keywords (up) Adult; Aged; Cross-Sectional Studies; Electroencephalography; Female; Humans; Hydrocortisone/analysis/metabolism; Male; Melatonin/analysis/metabolism; Middle Aged; Moon; Nontherapeutic Human Experimentation; Periodicity; Saliva/metabolism; Sleep/*physiology; Sleep Stages/physiology; Young Adult
Abstract Endogenous rhythms of circalunar periodicity ( approximately 29.5 days) and their underlying molecular and genetic basis have been demonstrated in a number of marine species [1, 2]. In contrast, there is a great deal of folklore but no consistent association of moon cycles with human physiology and behavior [3]. Here we show that subjective and objective measures of sleep vary according to lunar phase and thus may reflect circalunar rhythmicity in humans. To exclude confounders such as increased light at night or the potential bias in perception regarding a lunar influence on sleep, we retrospectively analyzed sleep structure, electroencephalographic activity during non-rapid-eye-movement (NREM) sleep, and secretion of the hormones melatonin and cortisol found under stringently controlled laboratory conditions in a cross-sectional setting. At no point during and after the study were volunteers or investigators aware of the a posteriori analysis relative to lunar phase. We found that around full moon, electroencephalogram (EEG) delta activity during NREM sleep, an indicator of deep sleep, decreased by 30%, time to fall asleep increased by 5 min, and EEG-assessed total sleep duration was reduced by 20 min. These changes were associated with a decrease in subjective sleep quality and diminished endogenous melatonin levels. This is the first reliable evidence that a lunar rhythm can modulate sleep structure in humans when measured under the highly controlled conditions of a circadian laboratory study protocol without time cues.
Address Centre for Chronobiology, Psychiatric Hospital of the University of Basel, 4012 Basel, Switzerland. christian.cajochen@upkbs.ch
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0960-9822 ISBN Medium
Area Expedition Conference
Notes PMID:23891110 Approved no
Call Number IDA @ john @ Serial 140
Permanent link to this record