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Author Landers, J.A.; Tamblyn, D.; Perriam, D.
Title Effect of a blue-light-blocking intraocular lens on the quality of sleep Type Journal Article
Year 2009 Publication Journal of Cataract and Refractive Surgery Abbreviated Journal J Cataract Refract Surg
Volume 35 Issue 1 Pages 83-88
Keywords (up) Aged; Aged, 80 and over; Circadian Rhythm/physiology; Female; Humans; *Lens Implantation, Intraocular; *Lenses, Intraocular; Light; Male; *Phacoemulsification; Prosthesis Design; Questionnaires; Sleep/*physiology; blue light; sleep
Abstract PURPOSE: To evaluate whether implantation of a blue-light-blocking intraocular lens (IOL) affects sleep quality. SETTING: Repatriation General Hospital, Adelaide, Australia. METHODS: This study comprised patients who had bilateral cataract surgery during the preceding 12 months with implantation of a conventional SI40NB IOL or an AcrySof Natural SN60WF blue-light-blocking IOL. Patients were contacted by telephone at least 6 months after second-eye surgery, and the Pittsburgh Sleep Quality Index (PSQI) questionnaire was administered. Results were compared between groups. RESULTS: Of the 49 patients, 31 received conventional IOLs and 18, blue-light-blocking IOLs. The mean age of the patients was 80 years +/- 8.1 (SD). The median PSQI score was 6 (interquartile range 3 to 8). There were no statistically significant differences in PSQI scores between the 2 IOL groups (P = .65). This remained true after adjustment for sex, age, medication, and time since surgery. CONCLUSION: The blue-light-blocking IOL had no effect on the sleep quality of patients, indicating that these IOLs might serve as an alternative to conventional IOLs without a detrimental effect on circadian rhythm.
Address Department of Ophthalmology, Repatriation General Hospital, Adelaide, Australia. john.landers@bigpond.com
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0886-3350 ISBN Medium
Area Expedition Conference
Notes PMID:19101429 Approved no
Call Number IDA @ john @ Serial 288
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Author Schmoll, C.; Khan, A.; Aspinall, P.; Goudie, C.; Koay, P.; Tendo, C.; Cameron, J.; Roe, J.; Deary, I.; Dhillon, B.
Title New light for old eyes: comparing melanopsin-mediated non-visual benefits of blue-light and UV-blocking intraocular lenses Type
Year 2014 Publication The British Journal of Ophthalmology Abbreviated Journal Br J Ophthalmol
Volume 98 Issue 1 Pages 124-128
Keywords (up) Aged; Cataract/*physiopathology; Circadian Rhythm/physiology; Cognition/*physiology; Female; Humans; Lens Implantation, Intraocular; *Lenses, Intraocular; Light; Male; Phacoemulsification; Prospective Studies; Questionnaires; Reaction Time/physiology; Regression Analysis; Rod Opsins/*physiology; Sleep/*physiology; Physiology; Retina; blue blocker; blue light
Abstract BACKGROUND/AIMS: Melanopsin-expressing photosensitive retinal ganglion cells form a blue-light-sensitive non-visual system mediating diverse physiological effects including circadian entrainment and cognitive alertness. Reduced blue wavelength retinal illumination through cataract formation is thought to blunt these responses while cataract surgery and intraocular lens (IOL) implantation have been shown to have beneficial effects on sleep and cognition. We aimed to use the reaction time (RT) task and the Epworth Sleepiness Score (ESS) as a validated objective platform to compare non-visual benefits of UV- and blue-blocking IOLs. METHODS: Patients were prospectively randomised to receive either a UV- or blue-blocking IOL, performing an RT test and ESS questionnaire before and after surgery. Optical blurring at the second test controlled for visual improvement. Non-operative age-matched controls were recruited for comparison. RESULTS: 80 participants completed the study. Those undergoing first-eye phacoemulsification demonstrated significant improvements in RT over control (p=0.001) and second-eye surgery patients (p=0.03). Moreover, reduced daytime sleepiness was measured by ESS for the first-eye surgery group (p=0.008) but not for the second-eye group (p=0.09). Choice of UV- or blue-blocking IOL made no significant difference to magnitude of cognitive improvement (p=0.272). CONCLUSIONS: Phacoemulsification, particularly first-eye surgery, has a strong positive effect on cognition and daytime alertness, regardless of IOL type.
Address Princess Alexandra Eye Hospital, , Edinburgh, UK
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0007-1161 ISBN Medium
Area Expedition Conference
Notes PMID:24158845 Approved no
Call Number IDA @ john @ Serial 342
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Author Obayashi, K.; Saeki, K.; Iwamoto, J.; Ikada, Y.; Kurumatani, N.
Title Exposure to light at night and risk of depression in the elderly Type Journal Article
Year 2013 Publication Journal of Affective Disorders Abbreviated Journal J Affect Disord
Volume 151 Issue 1 Pages 331-336
Keywords (up) Aged; Circadian Rhythm; Cross-Sectional Studies; Depression/*etiology; Female; Humans; Light/*adverse effects; Male; Melatonin/urine; Psychiatric Status Rating Scales; Risk Factors; Circadian rhythm; Daytime light; Depression; Elderly; Light at night; Melatonin; Mental Health
Abstract BACKGROUND: Recent advances in understanding the fundamental links between chronobiology and depressive disorders have enabled exploring novel risk factors for depression in the field of biological rhythms. Increased exposure to light at night (LAN) is common in modern life, and LAN exposure is associated with circadian misalignment. However, whether LAN exposure in home settings is associated with depression remains unclear. METHODS: We measured the intensities of nighttime bedroom light and ambulatory daytime light along with overnight urinary melatonin excretion (UME) in 516 elderly individuals (mean age, 72.8). Depressive symptoms were assessed using the Geriatric Depression Scale. RESULTS: The median nighttime light intensity was 0.8lx (interquartile range, 0.2-3.3). The depressed group (n=101) revealed significantly higher prevalence of LAN exposure (average intensity, >/= 5 lx) compared with that of the nondepressed group (n=415) using a multivariate logistic regression model adjusted for daytime light exposure, insomnia, hypertension, sleep duration, and physical activity [adjusted odds ratio (OR): 1.89; 95% confidence interval (CI), 1.10-3.25; P=0.02]. Consistently, another parameter of LAN exposure (duration of intensity >/= 10 lx, >/= 30 min) was significantly more prevalent in the depressed than in the nondepressed group (adjusted OR: 1.71; 95% CI, 1.01-2.89; P=0.046). In contrast, UME was not significantly associated with depressive symptoms. LIMITATION: Cross-sectional analysis. CONCLUSION: These results suggested that LAN exposure in home settings is significantly associated with depressive symptoms in the general elderly population. The risk of depression may be reduced by keeping nighttime bedroom dark.
Address Department of Community Health and Epidemiology, Nara Medical University School of Medicine, Nara, Japan. obayashi@naramed-u.ac.jp
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0165-0327 ISBN Medium
Area Expedition Conference
Notes PMID:23856285 Approved no
Call Number IDA @ john @ Serial 165
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Author Fonken, L.K.; Kitsmiller, E.; Smale, L.; Nelson, R.J.
Title Dim nighttime light impairs cognition and provokes depressive-like responses in a diurnal rodent Type Journal Article
Year 2012 Publication Journal of Biological Rhythms Abbreviated Journal J Biol Rhythms
Volume 27 Issue 4 Pages 319-327
Keywords (up) Analysis of Variance; Animals; CA1 Region, Hippocampal/cytology; CA3 Region, Hippocampal/cytology; Circadian Rhythm/*physiology; Cognition/*physiology/radiation effects; Corticosterone/blood; Dendrites/physiology/radiation effects; Dentate Gyrus/cytology; Depressive Disorder/*physiopathology; Food Preferences/physiology/radiation effects; Light; Male; Maze Learning/physiology/radiation effects; Motor Activity/physiology/radiation effects; Murinae/*physiology; Neurons/drug effects/physiology; *Photoperiod; Swimming/physiology
Abstract Circadian disruption is a common by-product of modern life. Although jet lag and shift work are well-documented challenges to circadian organization, many more subtle environmental changes cause circadian disruption. For example, frequent fluctuations in the timing of the sleep/wake schedule, as well as exposure to nighttime lighting, likely affect the circadian system. Most studies of these effects have focused on nocturnal rodents, which are very different from diurnal species with respect to their patterns of light exposure and the effects that light can have on their activity. Thus, the authors investigated the effect of nighttime light on behavior and the brain of a diurnal rodent, the Nile grass rat. Following 3 weeks of exposure to standard light/dark (LD; 14:10 light [~150 lux] /dark [0 lux]) or dim light at night (dLAN; 14:10 light [~150 lux] /dim [5 lux]), rats underwent behavioral testing, and hippocampal neurons within CA1, CA3, and the dentate gyrus (DG) were examined. Three behavioral effects of dLAN were observed: (1) decreased preference for a sucrose solution, (2) increased latency to float in a forced swim test, and (3) impaired learning and memory in the Barnes maze. Light at night also reduced dendritic length in DG and basilar CA1 dendrites. Dendritic length in the DG positively correlated with sucrose consumption in the sucrose anhedonia task. Nighttime light exposure did not disrupt the pattern of circadian locomotor activity, and all grass rats maintained a diurnal activity pattern. Together, these data suggest that exposure to dLAN can alter affective responses and impair cognition in a diurnal animal.
Address Department of Neuroscience, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA. fonken.1@osu.edu
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0748-7304 ISBN Medium
Area Expedition Conference
Notes PMID:22855576 Approved no
Call Number IDA @ john @ Serial 91
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Author Orbach, D.N.; Fenton, B.
Title Vision impairs the abilities of bats to avoid colliding with stationary obstacles Type Journal Article
Year 2010 Publication PloS one Abbreviated Journal PLoS One
Volume 5 Issue 11 Pages e13912
Keywords (up) Analysis of Variance; Animals; Chiroptera/*physiology; Cyclonic Storms; Echolocation/*physiology; Female; Flight, Animal/*physiology; Light; Male; Space Perception/physiology/radiation effects; Vision, Ocular/*physiology/radiation effects; Vocalization, Animal/physiology
Abstract BACKGROUND: Free-flying insectivorous bats occasionally collide with stationary objects they should easily detect by echolocation and avoid. Collisions often occur with lighted objects, suggesting ambient light may deleteriously affect obstacle avoidance capabilities. We tested the hypothesis that free-flying bats may orient by vision when they collide with some obstacles. We additionally tested whether acoustic distractions, such as “distress calls” of other bats, contributed to probabilities of collision. METHODOLOGY/PRINCIPAL FINDINGS: To investigate the role of visual cues in the collisions of free-flying little brown bats (Myotis lucifugus) with stationary objects, we set up obstacles in an area of high bat traffic during swarming. We used combinations of light intensities and visually dissimilar obstacles to verify that bats orient by vision. In early August, bats collided more often in the light than the dark, and probabilities of collision varied with the visibility of obstacles. However, the probabilities of collisions altered in mid to late August, coincident with the start of behavioural, hormonal, and physiological changes occurring during swarming and mating. Distress calls did not distract bats and increase the incidence of collisions. CONCLUSIONS/SIGNIFICANCE: Our findings indicate that visual cues are more important for free-flying bats than previously recognized, suggesting integration of multi-sensory modalities during orientation. Furthermore, our study highlights differences between responses of captive and wild bats, indicating a need for more field experiments.
Address Department of Biology, University of Western Ontario, London, Ontario, Canada. dnorbach@gmail.com
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1932-6203 ISBN Medium
Area Expedition Conference
Notes PMID:21085481; PMCID:PMC2976695 Approved no
Call Number IDA @ john @ Serial 96
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