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Author Dickerman, B.; Liu, J. url  doi
openurl 
  Title Does current scientific evidence support a link between light at night and breast cancer among female night-shift nurses? Review of evidence and implications for occupational and environmental health nurses Type Journal Article
  Year 2012 Publication Workplace Health & Safety Abbreviated Journal Workplace Health Saf  
  Volume 60 Issue 6 Pages 273-81; quiz 282  
  Keywords Human Health; Breast Neoplasms/*epidemiology/nursing; Chronobiology Disorders/*epidemiology/nursing; Education, Nursing, Continuing; Environmental Health; Evidence-Based Nursing; Female; Humans; Light; Night Care/*statistics & numerical data; *Occupational Health Nursing; Risk Factors; *Work Schedule Tolerance  
  Abstract Breast cancer is increasingly prevalent in industrialized regions of the world, and exposure to light at night (LAN) has been proposed as a potential risk factor. Epidemiological observations have documented an increased breast cancer risk among female night-shift workers, and strong experimental evidence for this relationship has also been found in rodent models. Indirect support for the LAN hypothesis comes from studies involving blind women, sleep duration, bedroom light levels, and community nighttime light levels. This article reviews the literature, discusses possible mechanisms of action, and provides recommendations for occupational health nursing research, practice, and education. Research is needed to further explore the relationship between exposure to LAN and breast cancer risk and elucidate the mechanisms underlying this relationship before interventions can be designed for prevention and mitigation of breast cancer.  
  Address MultiCare Good Samaritan Hospital, Puyallup, WA, USA. barbra.dickerman@gmail.com  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 2165-0799 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:22658734 Approved no  
  Call Number LoNNe @ christopher.kyba @ Serial 512  
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Author Summa, K.C.; Vitaterna, M.H.; Turek, F.W. url  doi
openurl 
  Title Environmental perturbation of the circadian clock disrupts pregnancy in the mouse Type Journal Article
  Year 2012 Publication PloS one Abbreviated Journal PLoS One  
  Volume 7 Issue 5 Pages e37668  
  Keywords Animals; Circadian Rhythm/*physiology; *Environment; Female; Locomotion/physiology; Mice; Mice, Inbred C57BL; Photoperiod; Pregnancy; Pregnancy Outcome; Reproduction/*physiology  
  Abstract BACKGROUND: The circadian clock has been linked to reproduction at many levels in mammals. Epidemiological studies of female shift workers have reported increased rates of reproductive abnormalities and adverse pregnancy outcomes, although whether the cause is circadian disruption or another factor associated with shift work is unknown. Here we test whether environmental disruption of circadian rhythms, using repeated shifts of the light:dark (LD) cycle, adversely affects reproductive success in mice. METHODOLOGY/PRINCIPAL FINDINGS: Young adult female C57BL/6J (B6) mice were paired with B6 males until copulation was verified by visual identification of vaginal plug formation. Females were then randomly assigned to one of three groups: control, phase-delay or phase-advance. Controls remained on a constant 12-hr light:12-hr dark cycle, whereas phase-delayed and phase-advanced mice were subjected to 6-hr delays or advances in the LD cycle every 5-6 days, respectively. The number of copulations resulting in term pregnancies was determined. Control females had a full-term pregnancy success rate of 90% (11/12), which fell to 50% (9/18; p<0.1) in the phase-delay group and 22% (4/18; p<0.01) in the phase-advance group. CONCLUSIONS/SIGNIFICANCE: Repeated shifting of the LD cycle, which disrupts endogenous circadian timekeeping, dramatically reduces pregnancy success in mice. Advances of the LD cycle have a greater negative impact on pregnancy outcomes and, in non-pregnant female mice, require longer for circadian re-entrainment, suggesting that the magnitude or duration of circadian misalignment may be related to the severity of the adverse impact on pregnancy. These results explicitly link disruptions of circadian entrainment to adverse pregnancy outcomes in mammals, which may have important implications for the reproductive health of female shift workers, women with circadian rhythm sleep disorders and/or women with disturbed circadian rhythms for other reasons.  
  Address Center for Sleep and Circadian Biology, Department of Neurobiology, Northwestern University, Evanston, Illinois, United States of America  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1932-6203 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:22649550; PMCID:PMC3359308 Approved no  
  Call Number IDA @ john @ Serial 92  
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Author Hansen, J.; Lassen, C.F. url  doi
openurl 
  Title Nested case-control study of night shift work and breast cancer risk among women in the Danish military Type Journal Article
  Year 2012 Publication Occupational and Environmental Medicine Abbreviated Journal Occup Environ Med  
  Volume 69 Issue 8 Pages 551-556  
  Keywords Adult; Aged; Aged, 80 and over; Breast Neoplasms/*etiology; Case-Control Studies; *Circadian Rhythm; Denmark/epidemiology; Female; Humans; Logistic Models; Middle Aged; Military Personnel; *Occupations; Odds Ratio; Risk Factors; *Sunlight; *Work; *Work Schedule Tolerance; oncogenesis  
  Abstract OBJECTIVES: Growing but limited evidence suggests that night shift work is associated with breast cancer. The authors conducted a nationwide case-control study nested within a cohort of 18,551 female military employees born in 1929-1968 to investigate the risk for breast cancer after night shift work and to explore the role of leisure time sun exposure and diurnal preference. METHODS: The authors documented 218 cases of breast cancer (1990-2003) and selected 899 age-matched controls from the cohort by incidence density sampling. Information on shift work, sun exposure habits, diurnal preference and other potential confounders was obtained from a structured questionnaire. ORs were estimated by multivariate conditional logistic regression. RESULTS: Overall, the authors observed an adjusted OR of 1.4 (95% CI 0.9 to 2.1) among women with ever compared with never night shifts. The RR for breast cancer tended to increase with increasing number of years of night shift work (p=0.03) and with cumulative number of shifts (p=0.02),with a neutral risk for fewer than three night shifts per week. The OR for the group with the highest tertile of cumulative exposure was 2.3 (95% CI 1.2 to 4.6). The most pronounced effect of night shift work on breast cancer risk was observed in women with morning chronotype preference and intense night shifts (OR=3.9, 95% CI 1.6 to 9.5). Night shift workers tended to sunbathe more frequently than day workers. CONCLUSIONS: The results indicate that frequent night shift work increases the risk for breast cancer and suggest a higher risk with longer duration of intense night shifts. Women with morning preference who worked on night shifts tended to have a higher risk than those with evening preference.  
  Address Institute of Cancer Epidemiology, Danish Cancer Society, Strandboulevarden 49, Copenhagen DK2100, Denmark. johnni@cancer.dk  
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  Language English Summary Language Original Title  
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  Series Volume Series Issue Edition  
  ISSN 1351-0711 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:22645325 Approved no  
  Call Number IDA @ john @ Serial 156  
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Author Barclay, J.L.; Husse, J.; Bode, B.; Naujokat, N.; Meyer-Kovac, J.; Schmid, S.M.; Lehnert, H.; Oster, H. url  doi
openurl 
  Title Circadian desynchrony promotes metabolic disruption in a mouse model of shiftwork Type Journal Article
  Year 2012 Publication PloS one Abbreviated Journal PLoS One  
  Volume 7 Issue 5 Pages e37150  
  Keywords Animals; Biological Clocks/*physiology; Circadian Rhythm/*physiology; Disease Models, Animal; Eating/genetics; Gene Expression Regulation; Liver/metabolism; Male; Mice; Sleep Disorders, Circadian Rhythm/*metabolism/physiopathology; Suprachiasmatic Nucleus/*metabolism; Transcriptome  
  Abstract Shiftwork is associated with adverse metabolic pathophysiology, and the rising incidence of shiftwork in modern societies is thought to contribute to the worldwide increase in obesity and metabolic syndrome. The underlying mechanisms are largely unknown, but may involve direct physiological effects of nocturnal light exposure, or indirect consequences of perturbed endogenous circadian clocks. This study employs a two-week paradigm in mice to model the early molecular and physiological effects of shiftwork. Two weeks of timed sleep restriction has moderate effects on diurnal activity patterns, feeding behavior, and clock gene regulation in the circadian pacemaker of the suprachiasmatic nucleus. In contrast, microarray analyses reveal global disruption of diurnal liver transcriptome rhythms, enriched for pathways involved in glucose and lipid metabolism and correlating with first indications of altered metabolism. Although altered food timing itself is not sufficient to provoke these effects, stabilizing peripheral clocks by timed food access can restore molecular rhythms and metabolic function under sleep restriction conditions. This study suggests that peripheral circadian desynchrony marks an early event in the metabolic disruption associated with chronic shiftwork. Thus, strengthening the peripheral circadian system by minimizing food intake during night shifts may counteract the adverse physiological consequences frequently observed in human shift workers.  
  Address Max Planck Institute of Biophysical Chemistry, Gottingen, Germany  
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  Language English Summary Language Original Title  
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  ISSN 1932-6203 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:22629359; PMCID:PMC3357388 Approved no  
  Call Number IDA @ john @ Serial 94  
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Author Titulaer, M.; Spoelstra, K.; Lange, C.Y.M.J.G.; Visser, M.E. url  doi
openurl 
  Title Activity patterns during food provisioning are affected by artificial light in free living great tits (Parus major) Type Journal Article
  Year 2012 Publication PloS one Abbreviated Journal PLoS One  
  Volume 7 Issue 5 Pages e37377  
  Keywords Animals; Appetitive Behavior/*physiology; Feeding Behavior/*physiology; Female; Light/*adverse effects; Male; Nesting Behavior/*physiology; Netherlands; Passeriformes/*physiology; Photoperiod; Sex Factors  
  Abstract Artificial light may have severe ecological consequences but there is limited experimental work to assess these consequences. We carried out an experimental study on a wild population of great tits (Parus major) to assess the impact of light pollution on daily activity patterns during the chick provisioning period. Pairs that were provided with a small light outside their nest box did not alter the onset, cessation or duration of their working day. There was however a clear effect of artificial light on the feeding rate in the second half of the nestling period: when provided with artificial light females increased their feeding rate when the nestlings were between 9 and 16 days old. Artificial light is hypothesised to have affected the perceived photoperiod of either the parents or the offspring which in turn led to increased parental care. This may have negative fitness consequences for the parents, and light pollution may thus create an ecological trap for breeding birds.  
  Address Department of Animal Ecology, Netherlands Institute of Ecology, Wageningen, The Netherlands  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
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  ISSN 1932-6203 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:22624023; PMCID:PMC3356403 Approved no  
  Call Number IDA @ john @ Serial 45  
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