| Records |
| Author |
Kayumov, L.; Casper, R.F.; Hawa, R.J.; Perelman, B.; Chung, S.A.; Sokalsky, S.; Shapiro, C.M. |
| Title |
Blocking low-wavelength light prevents nocturnal melatonin suppression with no adverse effect on performance during simulated shift work |
Type |
Journal Article |
| Year |
2005 |
Publication |
The Journal of Clinical Endocrinology and Metabolism |
Abbreviated Journal |
J Clin Endocrinol Metab |
| Volume |
90 |
Issue |
5 |
Pages |
2755-2761 |
| Keywords |
Lighting; Adult; *Circadian Rhythm; Female; Humans; *Light; Male; Melatonin/*secretion; *Work Schedule Tolerance |
| Abstract |
Decreases in melatonin production in human and animals are known to be caused by environmental lighting, especially short-wavelength lighting (between 470 and 525 nm). We investigated the novel hypothesis that the use of goggles with selective exclusion of all wavelengths less than 530 nm could prevent the suppression of melatonin in bright-light conditions during a simulated shift-work experiment. Salivary melatonin levels were measured under dim (<5 lux), bright (800 lux), and filtered (800 lux) light at hourly intervals between 2000 and 0800 h in 11 healthy young males and eight females (mean age, 24.7 +/- 4.6 yr). The measurements were performed during three nonconsecutive nights over a 2-wk period. Subjective sleepiness was measured by self-report scales, whereas objective performance was assessed with the Continuous Performance Test. All subjects demonstrated preserved melatonin levels in filtered light similar to their dim-light secretion profile. Unfiltered bright light drastically suppressed melatonin production. Normalization of endogenous melatonin production while wearing goggles did not impair measures of performance, subjective sleepiness, or alertness. |
| Address |
Sleep Research Laboratory, Department of Psychiatry, University Health Network, ECW 3D-035, 399 Bathurst Street, Toronto, Ontario, Canada M5T 2S8. lkayumov@uhnres.utoronto.ca |
| Corporate Author |
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Thesis |
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| Publisher |
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Place of Publication |
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Editor |
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| Language |
English |
Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
0021-972X |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
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| Notes |
PMID:15713707 |
Approved |
no |
| Call Number |
LoNNe @ kagoburian @ |
Serial |
640 |
| Permanent link to this record |
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| Author |
Meng, Y.; He, Z.; Yin, J.; Zhang, Y.; Zhang, T. |
| Title |
Quantitative calculation of human melatonin suppression induced by inappropriate light at night |
Type |
Journal Article |
| Year |
2011 |
Publication |
Medical & Biological Engineering & Computing |
Abbreviated Journal |
Med Biol Eng Comput |
| Volume |
49 |
Issue |
9 |
Pages |
1083-1088 |
| Keywords |
Algorithms; Circadian Rhythm/physiology/*radiation effects; Humans; *Lighting; Melatonin/*secretion; *Models, Biological; Retinal Cone Photoreceptor Cells/physiology/radiation effects; Retinal Ganglion Cells/physiology/radiation effects; Retinal Rod Photoreceptor Cells/physiology/radiation effects |
| Abstract |
Melatonin (C(1)(3)H(1)(6)N(2)O(2)) has a wide range of functions in the body. When is inappropriately exposed to light at night, human circadian rhythm will be interfered and then melatonin secretion will become abnormal. For nearly three decades great progresses have been achieved in analytic action spectra and melatonin suppression by various light conditions. However, so far few articles focused on the quantitative calculation of melatonin suppression induced by light. In this article, an algorithm is established, in which all the contributions of rods, cones, and intrinsically photosensitive retinal ganglion cells are considered. Calculation results accords with the experimental data in references very well, which indicate the validity of this algorithm. This algorithm can also interpret the rule of melatonin suppression varying with light correlated color temperature very well. |
| Address |
Photonics Research Center, School of Physics, Nankai University, Tianjin 300071, China |
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| Language |
English |
Summary Language |
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Original Title |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
0140-0118 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
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| Notes |
PMID:21717231 |
Approved |
no |
| Call Number |
IDA @ john @ |
Serial |
236 |
| Permanent link to this record |
