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Author (up) Fasciani, I.; Petragnano, F.; Aloisi, G.; Marampon, F.; Rossi, M.; Francesca Coppolino, M.; Rossi, R.; Longoni, B.; Scarselli, M.; Maggio, R.
Title A new threat to dopamine neurons: the downside of artificial light Type Journal Article
Year 2020 Publication Neuroscience Abbreviated Journal Neuroscience
Volume in press Issue Pages in press
Keywords Review; Human Health; Parkinson's disease; artificial light; dopamine neurons; melatonin; opsins; photoactivation
Abstract Growing awareness of adverse impacts of artificial light on human health has led to recognize light pollution as a significant global environmental issue. Despite, a large number of studies in rodent and monkey models of Parkinson's disease have reported that near infrared light has neuroprotective effects on dopaminergic neurons, recent findings have shown that prolonged exposure of rodents and birds to fluorescent artificial light results in an increase of neuromelanin granules in substantia nigra and loss of dopaminergic neurons. The observed detrimental effect seems to be dependent on a direct effect of light on the substantia nigra rather than a secondary effect of the alterations of circadian rhythms. Moreover, inferences from animal models to human studies have shown a positive correlation between the prevalence of Parkinson's disease and light pollution. The present article discusses experimental evidence supporting a potentially deleterious impact of light on dopaminergic neurons and highlights the mechanisms whereby light might damage neuronal tissue. Moreover, it analyses epidemiological evidence that suggests light pollution to be an environmental risk factor for Parkinson's disease.
Address Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy. Electronic address: roberto.maggio@univaq.it
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0306-4522 ISBN Medium
Area Expedition Conference
Notes PMID:32142863 Approved no
Call Number GFZ @ kyba @ Serial 2839
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Author (up) Maggio, R.; Vaglini, F.; Rossi, M.; Fasciani, I.; Pietrantoni, I.; Marampon, F.; Corsini, G.U.; Scarselli, M.; Millan, M.J.
Title Parkinson's disease and light: The bright and the Dark sides Type Journal Article
Year 2019 Publication Brain Research Bulletin Abbreviated Journal Brain Res Bull
Volume 150 Issue Pages 290-296
Keywords Humah Health; Light pollution; Near-infrared light; Parkinson's disease
Abstract Light exerts a major influence on human behaviour and health, mainly owing to the importance of sight in our lives, but also due to its entrainment of daily rhythms via the suprachiasmatic nucleus, the master pacemaker. Light may also be a useful clinical medium, as in lumino-therapy for the improvement of depressed mood. Further, as discussed herein, local application of near infrared light to the substantia nigra exerts neuroprotective properties in models of Parkinson's disease. However, light also has a darker side. In general, as regards the growing problem to human health – and the natural world – of excess exposure to artificial light: both urban glow and ubiquitous screens. Moreover, over-exposure to light, in particular fluorescent light, disrupts circadian rhythms and sleep, and may damage dopaminergic neurons. Is it, then, a neglected risk factor for Parkinson's disease? The present article discusses epidemiological and experimental evidence supporting beneficial and potentially deleterious impact of light on dopaminergic neurons and highlights the mechanisms whereby light might influence neuronal tissue.
Address Centre for Innovation in Neuropsychiatry, Institut de Recherches Servier, 125, Chemin de Ronde, 78290, Croissy sur Seine, France. Electronic address: mark.millan@servier.com
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0361-9230 ISBN Medium
Area Expedition Conference
Notes PMID:31226407 Approved no
Call Number GFZ @ kyba @ Serial 2586
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Author (up) Romeo, S. et al.
Title Bright light exposure reduces TH-positive dopamine neurons: implications of light pollution in Parkinson's disease epidemiology Type Journal Article
Year 2013 Publication Scientific Reports Abbreviated Journal
Volume 3 Issue Pages
Keywords Animals; Parkinson's disease; Cell death in the nervous system; Neural ageing; Risk factors
Abstract This study explores the effect of continuous exposure to bright light on neuromelanin formation and dopamine neuron survival in the substantia nigra. Twenty-one days after birth, Sprague–Dawley albino rats were divided into groups and raised under different conditions of light exposure. At the end of the irradiation period, rats were sacrificed and assayed for neuromelanin formation and number of tyrosine hydroxylase (TH)-positive neurons in the substantia nigra. The rats exposed to bright light for 20 days or 90 days showed a relatively greater number of neuromelanin-positive neurons. Surprisingly, TH-positive neurons decreased progressively in the substantia nigra reaching a significant 29% reduction after 90 days of continuous bright light exposure. This decrease was paralleled by a diminution of dopamine and its metabolite in the striatum. Remarkably, in preliminary analysis that accounted for population density, the age and race adjusted Parkinson's disease prevalence significantly correlated with average satellite-observed sky light pollution.
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number LoNNe @ christopher.kyba @ Serial 382
Permanent link to this record