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Author Ikeno, T.; Weil, Z.M.; Nelson, R.J. url  doi
openurl 
  Title Dim light at night disrupts the short-day response in Siberian hamsters Type Journal Article
  Year (down) 2014 Publication General and Comparative Endocrinology Abbreviated Journal Gen Comp Endocrinol  
  Volume 197 Issue Pages 56-64  
  Keywords 2,4-dinitro-1-flourobenzene; Dnfb; Dth; Eya3; Eyes absent 3; GnIH; GnRH; Immune function; Ld; Lps; Light pollution; Pt; Pelage; Per1; Period1; Photoperiodism; Rfrp; RFamide-related peptide; Scn; Sd; Seasonality; Tsh; TSH receptor; Tshr; dLAN; delayed-type hypersensitivity; dim light at night; gonadotropin-inhibiting hormone; gonadotropin-releasing hormone; lipopolysaccharide; long days; pars tuberalis; short days; suprachiasmatic nuclei; thyroid-stimulating hormone  
  Abstract Photoperiodic regulation of physiology, morphology, and behavior is crucial for many animals to survive seasonally variable conditions unfavorable for reproduction and survival. The photoperiodic response in mammals is mediated by nocturnal secretion of melatonin under the control of a circadian clock. However, artificial light at night caused by recent urbanization may disrupt the circadian clock, as well as the photoperiodic response by blunting melatonin secretion. Here we examined the effect of dim light at night (dLAN) (5lux of light during the dark phase) on locomotor activity rhythms and short-day regulation of reproduction, body mass, pelage properties, and immune responses of male Siberian hamsters. Short-day animals reduced gonadal and body mass, decreased spermatid nuclei and sperm numbers, molted to a whiter pelage, and increased pelage density compared to long-day animals. However, animals that experienced short days with dLAN did not show these short-day responses. Moreover, short-day specific immune responses were altered in dLAN conditions. The nocturnal activity pattern was blunted in dLAN hamsters, consistent with the observation that dLAN changed expression of the circadian clock gene, Period1. In addition, we demonstrated that expression levels of genes implicated in the photoperiodic response, Mel-1a melatonin receptor, Eyes absent 3, thyroid stimulating hormone receptor, gonadotropin-releasing hormone, and gonadotropin-inhibitory hormone, were higher in dLAN animals than those in short-day animals. These results suggest that dLAN disturbs the circadian clock function and affects the molecular mechanisms of the photoperiodic response.  
  Address Department of Neuroscience, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA. Electronic address: randy.nelson@osumc.edu  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0016-6480 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:24362257 Approved no  
  Call Number IDA @ john @ Serial 82  
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