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Author Behar-Cohen, F.; Martinsons, C.; Vienot, F.; Zissis, G.; Barlier-Salsi, A.; Cesarini, J.P.; Enouf, O.; Garcia, M.; Picaud, S.; Attia, D. url  doi
openurl 
  Title Light-emitting diodes (LED) for domestic lighting: any risks for the eye? Type Journal Article
  Year 2011 Publication Progress in Retinal and eye Research Abbreviated Journal Prog Retin Eye Res  
  Volume 30 Issue 4 Pages 239-257  
  Keywords Animals; Biomass; Circadian Rhythm/physiology; Environmental Exposure; Eye Diseases/*etiology/pathology/physiopathology; Humans; *Light/adverse effects; Lighting/*methods; Reflex, Pupillary/physiology; Retina/pathology; Risk Assessment; *Semiconductors; Time Factors  
  Abstract Light-emitting diodes (LEDs) are taking an increasing place in the market of domestic lighting because they produce light with low energy consumption. In the EU, by 2016, no traditional incandescent light sources will be available and LEDs may become the major domestic light sources. Due to specific spectral and energetic characteristics of white LEDs as compared to other domestic light sources, some concerns have been raised regarding their safety for human health and particularly potential harmful risks for the eye. To conduct a health risk assessment on systems using LEDs, the French Agency for Food, Environmental and Occupational Health & Safety (ANSES), a public body reporting to the French Ministers for ecology, for health and for employment, has organized a task group. This group consisted physicists, lighting and metrology specialists, retinal biologist and ophthalmologist who have worked together for a year. Part of this work has comprised the evaluation of group risks of different white LEDs commercialized on the French market, according to the standards and found that some of these lights belonged to the group risk 1 or 2. This paper gives a comprehensive analysis of the potential risks of white LEDs, taking into account pre-clinical knowledge as well as epidemiologic studies and reports the French Agency's recommendations to avoid potential retinal hazards.  
  Address Inserm UMRS 872, Physiopathology of Ocular Diseases: Therapeutic Innovations, Centre de Recherche des Cordeliers, Paris, France. Francine.behar-cohen@crc.jussieur.fr  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1350-9462 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:21600300 Approved no  
  Call Number IDA @ john @ Serial 240  
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Author Cajochen, C.; Frey, S.; Anders, D.; Spati, J.; Bues, M.; Pross, A.; Mager, R.; Wirz-Justice, A.; Stefani, O. url  doi
openurl 
  Title Evening exposure to a light-emitting diodes (LED)-backlit computer screen affects circadian physiology and cognitive performance Type Journal Article
  Year 2011 Publication Journal of Applied Physiology (Bethesda, Md. : 1985) Abbreviated Journal J Appl Physiol (1985)  
  Volume 110 Issue 5 Pages 1432-1438  
  Keywords Adult; Circadian Rhythm/*physiology/radiation effects; Cognition/*physiology/radiation effects; *Computer Terminals; Humans; Light; Lighting/*methods; Male; Photic Stimulation/*methods; Radiation Dosage; Semiconductors; *Task Performance and Analysis; Young Adult; blue light; sleep; circadian disruption  
  Abstract Many people spend an increasing amount of time in front of computer screens equipped with light-emitting diodes (LED) with a short wavelength (blue range). Thus we investigated the repercussions on melatonin (a marker of the circadian clock), alertness, and cognitive performance levels in 13 young male volunteers under controlled laboratory conditions in a balanced crossover design. A 5-h evening exposure to a white LED-backlit screen with more than twice as much 464 nm light emission {irradiance of 0,241 Watt/(steradian x m(2)) [W/(sr x m(2))], 2.1 x 10(13) photons/(cm(2) x s), in the wavelength range of 454 and 474 nm} than a white non-LED-backlit screen [irradiance of 0,099 W/(sr x m(2)), 0.7 x 10(13) photons/(cm(2) x s), in the wavelength range of 454 and 474 nm] elicited a significant suppression of the evening rise in endogenous melatonin and subjective as well as objective sleepiness, as indexed by a reduced incidence of slow eye movements and EEG low-frequency activity (1-7 Hz) in frontal brain regions. Concomitantly, sustained attention, as determined by the GO/NOGO task; working memory/attention, as assessed by “explicit timing”; and declarative memory performance in a word-learning paradigm were significantly enhanced in the LED-backlit screen compared with the non-LED condition. Screen quality and visual comfort were rated the same in both screen conditions, whereas the non-LED screen tended to be considered brighter. Our data indicate that the spectral profile of light emitted by computer screens impacts on circadian physiology, alertness, and cognitive performance levels. The challenge will be to design a computer screen with a spectral profile that can be individually programmed to add timed, essential light information to the circadian system in humans.  
  Address Centre for Chronobiology, Psychiatric Hospitals of the University of Basel, Basel, Switzerland. christian.cajochen@upkbs.ch  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0161-7567 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:21415172 Approved no  
  Call Number IDA @ john @ Serial 293  
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Author West, K.E.; Jablonski, M.R.; Warfield, B.; Cecil, K.S.; James, M.; Ayers, M.A.; Maida, J.; Bowen, C.; Sliney, D.H.; Rollag, M.D.; Hanifin, J.P.; Brainard, G.C. url  doi
openurl 
  Title Blue light from light-emitting diodes elicits a dose-dependent suppression of melatonin in humans Type Journal Article
  Year 2011 Publication Journal of Applied Physiology (Bethesda, Md. : 1985) Abbreviated Journal J Appl Physiol (1985)  
  Volume 110 Issue 3 Pages 619-626  
  Keywords Circadian Rhythm/*physiology/*radiation effects; Color; Dose-Response Relationship, Radiation; Humans; Lighting/*methods; Melatonin/*blood; Metabolic Clearance Rate/radiation effects; Photic Stimulation/*methods; Radiation Dosage; Retina/*physiology/*radiation effects; Semiconductors; Young Adult; blue light  
  Abstract Light suppresses melatonin in humans, with the strongest response occurring in the short-wavelength portion of the spectrum between 446 and 477 nm that appears blue. Blue monochromatic light has also been shown to be more effective than longer-wavelength light for enhancing alertness. Disturbed circadian rhythms and sleep loss have been described as risk factors for astronauts and NASA ground control workers, as well as civilians. Such disturbances can result in impaired alertness and diminished performance. Prior to exposing subjects to short-wavelength light from light-emitting diodes (LEDs) (peak lambda = 469 nm; 1/2 peak bandwidth = 26 nm), the ocular safety exposure to the blue LED light was confirmed by an independent hazard analysis using the American Conference of Governmental Industrial Hygienists exposure limits. Subsequently, a fluence-response curve was developed for plasma melatonin suppression in healthy subjects (n = 8; mean age of 23.9 +/- 0.5 years) exposed to a range of irradiances of blue LED light. Subjects with freely reactive pupils were exposed to light between 2:00 and 3:30 AM. Blood samples were collected before and after light exposures and quantified for melatonin. The results demonstrate that increasing irradiances of narrowband blue-appearing light can elicit increasing plasma melatonin suppression in healthy subjects (P < 0.0001). The data were fit to a sigmoidal fluence-response curve (R(2) = 0.99; ED(50) = 14.19 muW/cm(2)). A comparison of mean melatonin suppression with 40 muW/cm(2) from 4,000 K broadband white fluorescent light, currently used in most general lighting fixtures, suggests that narrow bandwidth blue LED light may be stronger than 4,000 K white fluorescent light for suppressing melatonin.  
  Address Dept. of Neurology, Thomas Jefferson Univ., Philadelphia, Pennsylvania 19107, USA  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0161-7567 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:21164152 Approved no  
  Call Number IDA @ john @ Serial 287  
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Author Zukauskas, A.; Vaicekauskas, R.; Vitta, P. url  doi
openurl 
  Title Optimization of solid-state lamps for photobiologically friendly mesopic lighting Type Journal Article
  Year 2012 Publication Applied Optics Abbreviated Journal Appl Opt  
  Volume 51 Issue 35 Pages 8423-8432  
  Keywords Lighting Systems; Circadian Rhythm; Color; Equipment Design; Humans; Light; *Lighting; Melatonin/metabolism; Photobiology/*methods; Semiconductors; Time Factors; Vision, Ocular  
  Abstract The circadian and visual-performance-based mesopic systems of photometry were applied for the optimization of the spectral power distributions (SPDs) of the solid-state sources of light for low-illuminance lighting applications. At mesopic adaptation luminances typical of outdoor lighting (0.1-2 cd/m(2)), the optimal SPDs were obtained through the minimization of the mesopic circadian action factor, which is the ratio of the circadian efficacy of radiation to mesopic luminous efficacy of radiation. For correlated color temperatures below ~3000 K, the optimized dichromatic light-emitting diodes (LEDs) are shown to pose a lower circadian hazard than high-pressure sodium lamps and common warm white LEDs; also they are potentially more efficacious and have acceptable color rendition properties under mesopic conditions.  
  Address Institute of Applied Research, Vilnius University, Sauletekio al. 9-III, Vilnius LT-10222, Lithuania. arturas.zukauskas@ff.vu.lt  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0003-6935 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:23262538 Approved no  
  Call Number LoNNe @ christopher.kyba @ Serial 448  
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