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Author Berson, D.M.; Dunn, F.A.; Takao, M.
Title Phototransduction by retinal ganglion cells that set the circadian clock Type Journal Article
Year 2002 Publication Science (New York, N.Y.) Abbreviated Journal Science
Volume 295 Issue (up) 5557 Pages 1070-1073
Keywords Human Health; Animals; Axons/ultrastructure; *Biological Clocks; *Circadian Rhythm; Dendrites/ultrastructure; Isoquinolines; Kinetics; Light; *Light Signal Transduction; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Retinal Ganglion Cells/chemistry/cytology/*physiology; Rod Opsins/analysis/physiology; Suprachiasmatic Nucleus/cytology/*physiology
Abstract Light synchronizes mammalian circadian rhythms with environmental time by modulating retinal input to the circadian pacemaker-the suprachiasmatic nucleus (SCN) of the hypothalamus. Such photic entrainment requires neither rods nor cones, the only known retinal photoreceptors. Here, we show that retinal ganglion cells innervating the SCN are intrinsically photosensitive. Unlike other ganglion cells, they depolarized in response to light even when all synaptic input from rods and cones was blocked. The sensitivity, spectral tuning, and slow kinetics of this light response matched those of the photic entrainment mechanism, suggesting that these ganglion cells may be the primary photoreceptors for this system.
Address Department of Neuroscience, Brown University, Providence, RI, 02912 USA. David_Berson@brown.edu
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0036-8075 ISBN Medium
Area Expedition Conference
Notes PMID:11834835 Approved no
Call Number LoNNe @ kagoburian @ Serial 720
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Author Foster, R.G.
Title Neurobiology: bright blue times Type Journal Article
Year 2005 Publication Nature Abbreviated Journal Nature
Volume 433 Issue (up) 7027 Pages 698-699
Keywords Human Health; Animals; Circadian Rhythm/physiology/radiation effects; Color Perception/physiology/*radiation effects; Humans; *Light; Light Signal Transduction/*radiation effects; Mice; Retinal Ganglion Cells/cytology/physiology/radiation effects; Retinaldehyde/chemistry/metabolism; Rod Opsins/*metabolism; NASA Discipline Space Human Factors; Non-NASA Center
Abstract
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0028-0836 ISBN Medium
Area Expedition Conference
Notes PMID:15716938 Approved no
Call Number LoNNe @ kagoburian @ Serial 750
Permanent link to this record