toggle visibility Search & Display Options

Select All    Deselect All
 |   | 
Details
   print
  Records Links
Author Filipski, E.; Subramanian, P.; Carriere, J.; Guettier, C.; Barbason, H.; Levi, F. url  doi
openurl 
  Title Circadian disruption accelerates liver carcinogenesis in mice Type Journal Article
  Year 2009 Publication Mutation Research Abbreviated Journal (up) Mutat Res  
  Volume 680 Issue 1-2 Pages 95-105  
  Keywords Human Health; Animals; Alanine Transaminase/blood; Animals; Aspartate Aminotransferases/blood; Bile Duct Neoplasms/chemically induced/pathology; Bile Ducts, Intrahepatic/drug effects/pathology; Body Weight/drug effects; Carcinogens/administration & dosage/*toxicity; Carcinoma, Hepatocellular/chemically induced/pathology; Cholangiocarcinoma/chemically induced/pathology; Circadian Rhythm/*drug effects; Diethylnitrosamine/administration & dosage/*toxicity; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Liver/drug effects/pathology; Liver Neoplasms/blood/*chemically induced/pathology; Male; Mice; Neoplasms, Multiple Primary/chemically induced/pathology; Sarcoma/chemically induced/pathology; Time Factors  
  Abstract BACKGROUND: The circadian timing system rhythmically controls behavior, physiology, cellular proliferation and xenobiotic metabolism over the 24-h period. The suprachiasmatic nuclei in the hypothalamus coordinate the molecular clocks in most mammalian cells through an array of circadian physiological rhythms including rest-activity, body temperature, feeding patterns and hormonal secretions. As a result, shift work that involves circadian disruption is probably carcinogenic in humans. In experimental models, chronic jet-lag (CJL) suppresses rest-activity and body temperature rhythms and accelerates growth of two transplantable tumors in mice. CJL also suppresses or significantly alters the expression rhythms of clock genes in liver and tumors. Circadian clock disruption from CJL downregulates p53 and upregulates c-Myc, thus favoring cellular proliferation. Here, we investigate the role of CJL as a tumor promoter in mice exposed to the hepatic carcinogen, diethylnitrosamine (DEN). METHODS: In experiment 1 (Exp 1), the dose-dependent carcinogenicity of chronic intraperitoneal (i.p.) administration of DEN was explored in mice. In Exp 2, mice received DEN at 10 mg/kg/day (cumulative dose: 243 mg/kg), then were randomized to remain in a photoperiodic regimen where 12 h of light alternates with 12 h of darkness (LD 12:12) or to be submitted to CJL (8-h advance of light onset every 2 days). Rest-activity and body temperature were monitored. Serum liver enzymes were determined repeatedly. Mice were sacrificed and examined for neoplastic lesions at 10 months. RESULTS: In Exp 1, DEN produced liver cancers in all the mice receiving 10 mg/kg/day. In Exp 2, mice on CJL had increased mean plasma levels of aspartate aminotransferase and more liver tumors as compared to LD mice at approximately 10 months (p = 0.005 and 0.028, respectively). The mean diameter of the largest liver tumor was twice as large in CJL vs LD mice (8.5 vs 4.4 mm, p = 0.027). In LD, a single histologic tumor type per liver was observed. In CJL, up to four different types were associated in the same liver (hepatocellular- or cholangio-carcinomas, sarcomas or mixed tumors). DEN itself markedly disrupted the circadian rhythms in rest-activity and body temperature in all the mice. DEN-induced disruption was prolonged for >or= 3 months by CJL exposure. CONCLUSIONS: The association of circadian disruption with chronic DEN exposure suggests that circadian clocks actively control the mechanisms of liver carcinogenesis in mice. Persistent circadian coordination may further be critical for slowing down and/or reverting cancer development after carcinogen exposure.  
  Address INSERM, U776 Rythmes Biologiques et Cancers, Hopital Paul Brousse, Villejuif F-94807, France  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0027-5107 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:19833225 Approved no  
  Call Number LoNNe @ kagoburian @ Serial 747  
Permanent link to this record
 

 
Author Owens, B. url  doi
openurl 
  Title Obesity: heavy sleepers Type Journal Article
  Year 2013 Publication Nature Abbreviated Journal (up) Nature  
  Volume 497 Issue 7450 Pages S8-9  
  Keywords Human Health; Animals; Body Mass Index; CLOCK Proteins/genetics/metabolism; Circadian Rhythm/physiology; Energy Metabolism/*physiology; Ghrelin/metabolism; Humans; Insulin Resistance/physiology; Leptin/metabolism; Male; Mice; Obesity/*physiopathology; Satiety Response/physiology; Sleep/*physiology; Suprachiasmatic Nucleus/physiology; Time Factors; Weight Gain/physiology; Weight Loss/physiology  
  Abstract  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0028-0836 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:23698508 Approved no  
  Call Number LoNNe @ christopher.kyba @ Serial 503  
Permanent link to this record
 

 
Author Rockhill, A.P.; DePerno, C.S.; Powell, R.A. url  doi
openurl 
  Title The effect of illumination and time of day on movements of bobcats (Lynx rufus) Type Journal Article
  Year 2013 Publication PloS one Abbreviated Journal (up) PLoS One  
  Volume 8 Issue 7 Pages e69213  
  Keywords Animals; Female; *Lighting; Lynx/*physiology; Male; Moon; Movement/*physiology; North Carolina; Time Factors; Wetlands  
  Abstract Understanding behavioral changes of prey and predators based on lunar illumination provides insight into important life history, behavioral ecology, and survival information. The objectives of this research were to determine if bobcat movement rates differed by period of day (dark, moon, crepuscular, day), lunar illumination (<10%, 10 – <50%, 50 – <90%, >90%), and moon phase (new, full). Bobcats had high movement rates during crepuscular and day periods and low movement rates during dark periods with highest nighttime rates at 10-<50% lunar illumination. Bobcats had highest movement rates during daytime when nighttime illumination was low (new moon) and higher movement rates during nighttime when lunar illumination was high (full moon). The behaviors we observed are consistent with prey availability being affected by light level and by limited vision by bobcats during darkness.  
  Address Fisheries, Wildlife, and Conservation Biology, North Carolina State University, Raleigh, North Carolina, USA. aimee_rockhill@ncsu.edu  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1932-6203 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:23861963; PMCID:PMC3704646 Approved no  
  Call Number IDA @ john @ Serial 84  
Permanent link to this record
 

 
Author Behar-Cohen, F.; Martinsons, C.; Vienot, F.; Zissis, G.; Barlier-Salsi, A.; Cesarini, J.P.; Enouf, O.; Garcia, M.; Picaud, S.; Attia, D. url  doi
openurl 
  Title Light-emitting diodes (LED) for domestic lighting: any risks for the eye? Type Journal Article
  Year 2011 Publication Progress in Retinal and eye Research Abbreviated Journal (up) Prog Retin Eye Res  
  Volume 30 Issue 4 Pages 239-257  
  Keywords Animals; Biomass; Circadian Rhythm/physiology; Environmental Exposure; Eye Diseases/*etiology/pathology/physiopathology; Humans; *Light/adverse effects; Lighting/*methods; Reflex, Pupillary/physiology; Retina/pathology; Risk Assessment; *Semiconductors; Time Factors  
  Abstract Light-emitting diodes (LEDs) are taking an increasing place in the market of domestic lighting because they produce light with low energy consumption. In the EU, by 2016, no traditional incandescent light sources will be available and LEDs may become the major domestic light sources. Due to specific spectral and energetic characteristics of white LEDs as compared to other domestic light sources, some concerns have been raised regarding their safety for human health and particularly potential harmful risks for the eye. To conduct a health risk assessment on systems using LEDs, the French Agency for Food, Environmental and Occupational Health & Safety (ANSES), a public body reporting to the French Ministers for ecology, for health and for employment, has organized a task group. This group consisted physicists, lighting and metrology specialists, retinal biologist and ophthalmologist who have worked together for a year. Part of this work has comprised the evaluation of group risks of different white LEDs commercialized on the French market, according to the standards and found that some of these lights belonged to the group risk 1 or 2. This paper gives a comprehensive analysis of the potential risks of white LEDs, taking into account pre-clinical knowledge as well as epidemiologic studies and reports the French Agency's recommendations to avoid potential retinal hazards.  
  Address Inserm UMRS 872, Physiopathology of Ocular Diseases: Therapeutic Innovations, Centre de Recherche des Cordeliers, Paris, France. Francine.behar-cohen@crc.jussieur.fr  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1350-9462 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:21600300 Approved no  
  Call Number IDA @ john @ Serial 240  
Permanent link to this record
 

 
Author Dukic, T.; Ahlstrom, C.; Patten, C.; Kettwich, C.; Kircher, K. url  doi
openurl 
  Title Effects of electronic billboards on driver distraction Type Journal Article
  Year 2013 Publication Traffic Injury Prevention Abbreviated Journal (up) Traffic Inj Prev  
  Volume 14 Issue 5 Pages 469-476  
  Keywords Adult; Advertising as Topic/*methods; *Attention; Automobile Driving/*psychology; Eye Movements; Humans; Middle Aged; Psychomotor Performance; Sweden; Time Factors  
  Abstract OBJECTIVE: There is an increase in electronic advertising billboards along major roads, which may cause driver distraction due to the highly conspicuous design of the electronic billboards. Yet limited research on the impact of electronic billboards on driving performance and driver behavior is available. The Swedish Transport Administration recently approved the installation of 12 electronic billboards for a trial period along a 3-lane motorway with heavy traffic running through central Stockholm, Sweden. The aim of this study was to evaluate the effect of these electronic billboards on visual behavior and driving performance. METHOD: A total of 41 drivers were recruited to drive an instrumented vehicle passing 4 of the electronic billboards during day and night conditions. A driver was considered visually distracted when looking at a billboard continuously for more than 2 s or if the driver looked away from the road for a high percentage of time. Dependent variables were eye-tracking measures and driving performance measures. RESULTS: The visual behavior data showed that drivers had a significantly longer dwell time, a greater number of fixations, and longer maximum fixation duration when driving past an electronic billboard compared to other signs on the same road stretches. No differences were found for the factors day/night, and no effect was found for the driving behavior data. CONCLUSION: Electronic billboards have an effect on gaze behavior by attracting more and longer glances than regular traffic signs. Whether the electronic billboards attract too much attention and constitute a traffic safety hazard cannot be answered conclusively based on the present data.  
  Address Swedish National Road and Transport Research Institute, Linkoping, Sweden. tania.dukic@vti.se  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1538-9588 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:23682577 Approved no  
  Call Number IDA @ john @ Serial 247  
Permanent link to this record
Select All    Deselect All
 |   | 
Details
   print

Save Citations:
Export Records: